Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Lawrence M. Ryan"'
Publikováno v:
Bone. 110:96-106
Hypophosphatasia (HPP) is the inborn-error-of-metabolism due to loss-of-function mutation(s) of the ALPL (TNSALP) gene that encodes the tissue non-specific isoenzyme of alkaline phosphatase (TNSALP). TNSALP represents a family of cell-surface phospho
Autor:
Lawrence M. Ryan, Ann K. Rosenthal
Publikováno v:
New England Journal of Medicine. 374:2575-2584
CPPD disease (also called pseudogout) is common, especially among persons older than 60 years of age, but it is underrecognized and undertreated. This review summarizes the diagnosis and treatment of the acute and chronic forms of this crystal-induce
Publikováno v:
Seminars in arthritis and rheumatism. 48(1)
Objective Calcium pyrophosphate deposition disease (CPDD) is arthritis caused by calcium pyrophosphate (CPP) crystal deposition in joints. It is commonly associated with aging as well as a handful of metabolic syndromes. Recent epidemiologic studies
Publikováno v:
The Journal of Rheumatology. 41:65-74
Objective.Accumulation of excess extracellular inorganic pyrophosphate leads to calcium pyrophosphate dihydrate (CPPD) crystal formation in articular cartilage. CPPD crystal formation occurs near morphologically abnormal chondrocytes resembling hyper
Autor:
Trusha Patel, Melissa DuBois, Lawrence M. Ryan, Alexis Visotcky, Jennifer Mulkerin, Rajeev Mannem, Keith Baynes, Guillermo F. Carrera
Publikováno v:
Clinical rheumatology. 35(3)
Calcium pyrophosphate dihydrate (CPP) crystal deposition in the articular cartilage can often be seen radiographically as chondrocalcinosis (CC). CPP crystals preferentially deposit in fibrocartilages such as the knee menisci and symphysis pubis (SP)
Autor:
Meetha Medhora, Ann K. Rosenthal, Ikuko Masuda, Jill C Costello, Indira V. Kurup, Lawrence M. Ryan
Publikováno v:
Connective Tissue Research. 52:139-146
Extracellular inorganic pyrophosphate (ePPi) is a key regulator of pathologic mineralization in articular cartilage. Articular chondrocytes generate ePPi by the transportation of intracellular PPi (iPPi) through transport mechanisms such as ANK or by
Autor:
Edda Haberlandt, Steven Mumm, Michael P. Whyte, Sara Baumgartner-Sigl, Karen L. Ericson, Sabine Scholl-Bürgi, Consolato Sergi, Wolfgang Högler, Lawrence M. Ryan
Publikováno v:
Bone. 40:1655-1661
Pyridoxine-responsive seizures (PRS) and the role of pyridoxine (PN, vitamin B(6)) in hypophosphatasia (HPP) are incompletely understood. Typically, PRS and HPP are rare, independent, metabolic disorders. In PRS, seizures resist standard anticonvulsa
Autor:
Michael P. Whyte, Wouter Beertsen, T. van den Bos, G. Handoko, A. Niehof, Stephen P. Coburn, Lawrence M. Ryan
Publikováno v:
van den Bos, T, Handoko, G, Niehof, A, Ryan, L M, Coburn, S P, Whyte, M P & Beertsen, W 2005, ' Cementum and dentin in hypophosphatasia ', Journal of Dental Research, vol. 84, pp. 1021-1025 . https://doi.org/10.1177/154405910508401110
Journal of Dental Research, 84, 1021-1025. SAGE Publications Inc.
Journal of Dental Research, 84, 1021-1025. SAGE Publications Inc.
Hypophosphatasia (HPP) often leads to premature loss of deciduous teeth, due to disturbed cementum formation. We addressed the question to what extent cementum and dentin are similarly affected. To this end, we compared teeth from children with HPP w
Autor:
Lawrence M. Ryan, Jill C Costello
Publikováno v:
Current Opinion in Rheumatology. 16:268-272
Extracellular inorganic pyrophosphate (ePPi) both inhibits and promotes different forms of pathologic mineralization. Basic calcium phosphate (BCP) deposition results from depressed levels of ePPi while excess levels of ePPi leads to calcium pyrophos
Publikováno v:
Arthritis & Rheumatism. 46:3218-3229
Objective Excess accumulation of extracellular inorganic pyrophosphate (ePPi) in aged human cartilage is crucial in calcium pyrophosphate dihydrate (CPPD) crystal formation in cartilage matrix. Two sources of ePPi are ePPi-generating ectoenzymes (NTP