Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Lawrence M. Mylin"'
Publikováno v:
The Journal of Immunology. 189:5549-5560
Altered peptide ligands (APLs) with enhanced binding to MHC class I can increase the CD8+ T cell response to native Ags, including tumor Ags. In this study, we investigate the influence of peptide–MHC (pMHC) stability on recruitment of tumor Ag-spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c53146d3a45c3dd3bbbb691017bc4d7d
https://doi.org/10.4049/jimmunol.1102221
https://doi.org/10.4049/jimmunol.1102221
Autor:
Todd D. Schell, Angela M. Tatum, Satvir S. Tevethia, Beth A. Vigliotti, Matthew A. Fischer, Lawrence M. Mylin, M. Judith Tevethia, Susan J. Bender
Publikováno v:
The Journal of Immunology. 181:4406-4417
Immunotherapy of established solid tumors is rarely achieved, and the mechanisms leading to success remain to be elucidated. We previously showed that extended control of advanced-stage autochthonous brain tumors is achieved following adoptive transf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2ddb5347d837684088001ff001c78de
https://doi.org/10.4049/jimmunol.181.6.4406
https://doi.org/10.4049/jimmunol.181.6.4406
Autor:
April Allebach, Todd D. Schell, Satvir S. Tevethia, David Assis, Melanie Epler, Caroline Kusuma, Lawrence M. Mylin, Chelsea Matsko, Alexandra Smith Smith
Publikováno v:
Virology. 364:155-168
To better understand the relationship between epitope variation and tumor escape from immune surveillance, SV40 T antigen-transformed B6/K-0 cells were subjected to selection with individual CTL clones specific for the SV40 T antigen H-2D b -restrict
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83001244c3b0ff6c6ca59d55d34dbfe8
https://doi.org/10.1016/j.virol.2007.02.007
https://doi.org/10.1016/j.virol.2007.02.007
Autor:
Sandra C. Hutchinson, M. Judith Tevethia, Lawrence M. Mylin, Todd D. Schell, Satvir S. Tevethia, Pavel Otahal
Publikováno v:
The Journal of Immunology. 175:700-712
CD8+ T lymphocytes (TCD8) responding to subdominant epitopes provide alternate targets for the immunotherapy of cancer, particularly when self-tolerance limits the response to immunodominant epitopes. However, the mechanisms that promote TCD8 subdomi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c282851f9fd11d4fa042c89c2c5d8fc9
https://doi.org/10.4049/jimmunol.175.2.700
https://doi.org/10.4049/jimmunol.175.2.700
Autor:
Alina Boesteanu, Melanie Epler, Jeffrey A. Frelinger, Todd D. Schell, Sebastian Joyce, Edward J. Collins, Satvir S. Tevethia, Lawrence M. Mylin, Debra Roberts
Publikováno v:
Journal of Virology. 74:6922-6934
The cytotoxic T-lymphocyte response to wild-type simian virus 40 large tumor antigen (Tag) in C57BL/6 (H2b) mice is directed against threeH2-Db-restricted epitopes, I, II/III, and V, and oneH2-Kb-restricted epitope, IV. Epitopes I, II/III, and IV are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3080a1bedc520f15e0d2a488f431eae1
https://doi.org/10.1128/jvi.74.15.6922-6934.2000
https://doi.org/10.1128/jvi.74.15.6922-6934.2000
Autor:
Lawrence M. Mylin
Publikováno v:
The Journal of Immunology. 162:2171-2179
SV40 large tumor Ag (Tag) contains four H-2b-restricted (I, II/III, IV, and V) CTL epitopes. A hierarchy exists among these CTL epitopes. CTL directed against epitopes I, II/III, and IV are readily detected following immunization of H-2b mice with SV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9801e3800dc6164970d3adb7b5dc336
https://doi.org/10.4049/jimmunol.162.4.2171
https://doi.org/10.4049/jimmunol.162.4.2171
Autor:
Robert H. Bonneau, Yoshihiro Kawaoka, Joseph E. Blaney, Eri Nobusawa, Satvir S. Tevethia, Michael A. Brehm, Lawrence M. Mylin, Tong-Ming Fu
Publikováno v:
Journal of Virology. 72:9567-9574
We have evaluated the potential of conferring protective immunity to herpes simplex virus type 2 (HSV-2) by selectively inducing an HSV-specific CD8 + cytotoxic T-lymphocyte (CTL) response directed against a single major histocompatibility complex cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d53ff855721ab1e8d566a90fb0d6827
https://doi.org/10.1128/jvi.72.12.9567-9574.1998
https://doi.org/10.1128/jvi.72.12.9567-9574.1998
Autor:
Alina Boesteanu, Michael Brehm, Lawrence M. Mylin, Gregory J. Christianson, Satvir S. Tevethia, Derry C. Roopenian, Sebastian Joyce
Publikováno v:
The Journal of Immunology. 161:4719-4727
CD8+ T cells respond to Ags when their clonotypic receptor, the TCR, recognizes nonself peptides displayed by MHC class I molecules. The TCR/ligand interactions are degenerate because, in its life time, the TCR interacts with self MHC class I-self pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca6b5b2c9c436d9803d9b0f66ee7c405
https://doi.org/10.4049/jimmunol.161.9.4719
https://doi.org/10.4049/jimmunol.161.9.4719
Publikováno v:
Virology. 244(2):427-441
SV40-transformed mKSA cells ( H-2 d ) readily induce progressively growing tumors in adult syngeneic BALB/c mice while expressing the full complement of H-2 d MHC class I antigens. BALB/c mice previously immunized with SV40, soluble SV40 T antigen, o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4339b1b9b23ff6693617a7a33c1d02ec
Autor:
Todd D. Schell, Tong-Ming Fu, Lawrence M. Mylin, Igor Bacik, Satvir S. Tevethia, Jack R. Bennink, Gustav Russ, Jonathan W. Yewdell
Publikováno v:
Journal of Virology. 72:1469-1481
Cells infected with viruses or undergoing oncogenic transformation express new or altered self-proteins that may trigger host immune responses. CD8+ cytotoxic T lymphocytes (CTL) recognize such proteins in the form of small antigenic peptide fragment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc520db4e62f9a82c54c2aa517c38d95
https://doi.org/10.1128/jvi.72.2.1469-1481.1998
https://doi.org/10.1128/jvi.72.2.1469-1481.1998