Zobrazeno 1 - 10
of 408
pro vyhledávání: '"Lawrence M. Lichtenstein"'
Autor:
Peter S. Creticos, Lawrence M. Lichtenstein, Robert G. Hamilton, N. Franklin Adkinson, Philip S. Norman
Publikováno v:
International archives of allergy and immunology. 99(2-4)
For approaches to the immunotherapy of allergic respiratory diseases now under study at Johns Hopkins are reviewed. Traditional high dose parenteral immunization with mixtures of allergens corresponding to patients’ allergic sensitivities is being
Autor:
Michele, Columbo, Edward M, Horowitz, Luis M, Botana, Donald W, MacGlashan, Bruce S, Bochner, Steven, Gillis, Krisztina M, Zsebo, Stephen J, Galli, Lawrence M, Lichtenstein
Publikováno v:
International archives of allergy and immunology. 99(2-4)
We studied the activity of recombinant human stem cell factor (rhSCF) on the release of mediators from human skin mast cells. High concentrations of rhSCF (1 ng/ml-1 μg/ml) induced a rapid and sustained rise in intracellular Ca2+ levels that was acc
Autor:
Lawrence M. Lichtenstein, David B.K. Golden, Satoshi Konno, John T. Schroeder, Robert G. Hamilton, Shau Ku Huang
Publikováno v:
Journal of Allergy and Clinical Immunology. 115:1063-1067
Background Venom allergen immunotherapy (VIT) is proven to be highly effective for insect allergy, but the mechanisms and the biomarkers associated with clinical efficacy remain elusive. Objective The aim of this study was to identify candidate bioma
Publikováno v:
Clinical Experimental Allergy Reviews. 4:224-228
Summary This paper describes the early work done with allergen immunotherapy in the treatment of allergic rhinitis and asthma. Furthermore, it cites the mechanistic studies that help define the therapeutic effect of specific allergen immunotherapy. I
Autor:
Philip S. Norman, Robert G. Hamilton, David B.K. Golden, Anne Kagey-Sobotka, Lawrence M. Lichtenstein
Publikováno v:
New England Journal of Medicine. 351:668-674
background Children are thought to “outgrow” the allergy to insect stings, but there are no reports documenting the natural history of this reaction. We studied the outcome of allergic reactions to insect stings in childhood 10 to 20 years afterw
Autor:
Philip S. Norman, David B.K. Golden, Anne Kagey-Sobotka, Robert G. Hamilton, Lawrence M. Lichtenstein
Publikováno v:
Journal of Allergy and Clinical Immunology. 107:897-901
Background: In our 1976 controlled venom immuno rapy trial, 33% of 182 patients with a history of systemic reactions to insect stings were excluded because of negative venom skin test responses. There have been reports of patients with negative skin
Publikováno v:
Journal of Allergy and Clinical Immunology. 107:265-271
Background: Human blood basophils secrete high levels of IL-4 following activation with specific allergen, yet their role as cytokine-producing cells in allergic lesions has not been described. Objective: Our objective was to investigate whether and
Publikováno v:
Inflammation. 1(2)
A complement-independent eosinophil chemotactic factor (ECF) is described which is released from peripheral leukocytes of allergic and normal human volunteers after antigen stimulation and after exposure to anti-IgE. Dose response and time-release cu
Autor:
David A. Schwartz, Joseph Eiden, Stephen Tuck, Anne Kagey-Sobotka, Gary Van Nest, Peter S. Creticos, Kenji Takabayashi, H Tighe, Lawrence M. Lichtenstein, Hans L. Spiegelberg, Eyal Raz
Publikováno v:
Journal of Allergy and Clinical Immunology. 106:124-134
Background: Allergen immunotherapy is inconvenient and associated with the risk of anaphylaxis. Efforts to improve the safety of immunotherapy by means of chemical modification of allergens have not been successful because it greatly reduced their an