Zobrazeno 1 - 10
of 236
pro vyhledávání: '"Lawrence M Pfeffer"'
Autor:
Baojin Wang, Xia Li, Guannan Zhao, Huan Yan, Peixin Dong, Hidemichi Watari, Michelle Sims, Wei Li, Lawrence M Pfeffer, Yuqi Guo, Junming Yue
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 37, Iss 1, Pp 1-9 (2018)
Abstract Background We previously reported that miR-203 functions as a tumor suppressor in ovarian cancer cells by directly targeting transcription factor Snai2 and inhibiting epithelial to mesenchymal transition (EMT), whereas BIRC5/survivin promote
Externí odkaz:
https://doaj.org/article/802d8872d297424f9bd2e60fe45bd88d
Autor:
Yinan Wang, Chuanhe Yang, Qingqing Gu, Michelle Sims, Weiwang Gu, Lawrence M Pfeffer, Junming Yue
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130341 (2015)
The transcription factor Krüppel-like factor 4 (KLF4) has been implicated in regulating cell proliferation, migration and differentiation in a variety of human cells and is one of four factors required for the induction of pluripotent stem cell repr
Externí odkaz:
https://doaj.org/article/eb71a6833302487e8183713c7111ee91
Autor:
Jo Meagan Garner, David W Ellison, David Finkelstein, Debolina Ganguly, Ziyun Du, Michelle Sims, Chuan He Yang, Rodrigo B Interiano, Andrew M Davidoff, Lawrence M Pfeffer
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145052 (2015)
[This corrects the article DOI: 10.1371/journal.pone.0125838.].
Externí odkaz:
https://doaj.org/article/4005f6d2dd6144caac3c875c6fd92903
Autor:
Jo Meagan Garner, David W Ellison, David Finkelstein, Debolina Ganguly, Ziyun Du, Michelle Sims, Chuan He Yang, Rodrigo B Interiano, Andrew M Davidoff, Lawrence M Pfeffer
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0125838 (2015)
Malignant glioblastoma (GBM) is a highly aggressive brain tumor with a dismal prognosis and limited therapeutic options. Genomic profiling of GBM samples has identified four molecular subtypes (Proneural, Neural, Classical and Mesenchymal), which may
Externí odkaz:
https://doaj.org/article/3e1b959d254b4258a12fcead3ad95b12
Autor:
Lawrence M Pfeffer, Kui Li, Jaquelyn F Fleckenstein, Tony N Marion, Joel Diament, Chuan He Yang, Susan R Pfeffer, Meiyun Fan, Elizabeth Handorf, Charles R Handorf
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104202 (2014)
Infection with the hepatitis C virus (HCV) is a major cause of chronic liver diseases and hepatocellular carcinoma worldwide, and thus represents a significant public health problem. The type I interferon (IFN), IFNα, has been successful in treating
Externí odkaz:
https://doaj.org/article/863f31a63f774ff18820ba4b3641ffbd
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71130 (2013)
EF24 is a curcumin analog that has improved anticancer activity over curcumin, but its therapeutic potential and mechanism of action is unknown, which is important to address as curcumin targets multiple signaling pathways. EF24 inhibits the NF-κB b
Externí odkaz:
https://doaj.org/article/9e5ae5d0978244018844f60fda6e9e67
Autor:
W Shannon Orr, Jason W Denbo, Karim R Saab, Catherine Y Ng, Jianrong Wu, Kui Li, Jo Meagan Garner, Christopher L Morton, Ziyun Du, Lawrence M Pfeffer, Andrew M Davidoff
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e51309 (2013)
Ionizing radiation (IR) is an essential component of therapy for alveolar rhabdomyosarcoma. Nuclear factor-kappaB (NF-κΒ) transcription factors are upregulated by IR and have been implicated in radioresistance. We evaluated the ability of curcumin,
Externí odkaz:
https://doaj.org/article/4d3ecc0d722741a299a76b3a89596805
Autor:
Zorica Janjetovic, Michal A Zmijewski, Robert C Tuckey, Damon A DeLeon, Minh N Nguyen, Lawrence M Pfeffer, Andrzej T Slominski
Publikováno v:
PLoS ONE, Vol 4, Iss 6, p e5988 (2009)
The side chain of vitamin D3 is hydroxylated in a sequential manner by cytochrome P450scc (CYP11A1) to form 20-hydroxycholecalciferol, which can induce growth arrest and differentiation of both primary and immortalized epidermal keratinocytes. Since
Externí odkaz:
https://doaj.org/article/0c9c17732bd242c79824e083def92134
Autor:
Sarah Asemota, Wendy Effah, Kirsten L. Young, Jeremiah Holt, Linnea Cripe, Suriyan Ponnusamy, Thirumagal Thiyagarajan, Dong-Jin Hwang, Yali He, Keely Mcnamara, Daniel Johnson, Yinan Wang, Brandy Grimes, Yekta Khosrosereshki, T.J. Hollingsworth, Martin D. Fleming, Frances E. Pritchard, Ashley Hendrix, Farhan Khan, Meiyun Fan, Liza Makowski, Zheng Yin, Hironobu Sasano, D. Neil Hayes, Lawrence M. Pfeffer, Duane D. Miller, Ramesh Narayanan
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113461- (2023)
Summary: Triple-negative breast cancer (TNBC) is an aggressive subtype with no targeted therapeutics. The luminal androgen receptor (LAR) subtype constitutes 15% of TNBC and is enriched for androgen receptor (AR) and AR target genes. Here, we show th
Externí odkaz:
https://doaj.org/article/ac241ea52bf347e5b56f2020cc95e398
Publikováno v:
Autophagy Reports, Vol 1, Iss 1, Pp 385-388 (2022)
The aggressive brain cancer glioblastoma (GBM) is notoriously resistant to radiotherapy and chemotherapy, which drives tumor recurrence and relapse. GBM cells are highly addicted to STAT3 (signal transducer and activator of transcription 3) and STAT3
Externí odkaz:
https://doaj.org/article/ed062b443e3543afaa92eaf263ca3e11