Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Lawrence Kuo"'
Autor:
Alexander Lawrence Kuo, 郭柏寬
104
It is often to use a control speaker and a dual microphones system consisting of reference microphone and error microphone for active noise control (ANC) in practical applications. Sound propagations from the control speaker to the reference
It is often to use a control speaker and a dual microphones system consisting of reference microphone and error microphone for active noise control (ANC) in practical applications. Sound propagations from the control speaker to the reference
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/28526607305420317911
Autor:
S. D. Lewis, Youwei Yan, Richard C.A. Isaacs, M. G. Solinsky, Lawrence Kuo, Julie A. Krueger, Bobby J. Lucas, Kellie J. Cutrona, Elizabeth A. Lyle, Adel M. Naylor-Olsen, Christina L. Newton, Daniel R. McMasters, J.J. Lynch
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:2062-2066
Guided by X-ray crystallography of thrombin-inhibitor complexes and molecular modeling, alkylation of the N1 nitrogen of the imidazole P1 ligand of the pyridinoneacetamide thrombin inhibitor 1 with various acetamide moieties furnished inhibitors with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da1f51337db1ab8622bb97fcfc58a61e
https://doi.org/10.1016/j.bmcl.2008.01.098
https://doi.org/10.1016/j.bmcl.2008.01.098
Autor:
James Hardwick, Xianzhi Mao, Constanine Kreatsoulas, Eileen S. Walsh, Sanjeev Munshi, Marc Abrams, George D. Hartman, Laura Sepp-Lorenzino, Mark E. Fraley, Rob Lobell, Kelly Hamilton, Lawrence Kuo, Carolyn A. Buser, Weikang Tao, Robert M. Garbaccio, Mari Ikuta, Keith W. Rickert, Edward S. Tasber, Bob Drakas, Steve Stirdivant, Stephen C. Beck, Shaei Huang, Youwei Yan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:6280-6285
From HTS lead 1, a novel benzoisoquinolinone class of ATP-competitive Chk1 inhibitors was devised and synthesized via a photochemical route. Using X-ray crystallography as a guide, potency was rapidly enhanced through the installation of a tethered b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8392ef471e763e4ddf93eeb0d6112007
https://doi.org/10.1016/j.bmcl.2007.09.007
https://doi.org/10.1016/j.bmcl.2007.09.007
Autor:
Eileen S. Walsh, Steve Stirdivant, George D. Hartman, Kelly Hamilton, Marc Abrams, Robert M. Garbaccio, Laura Sepp-Lorenzino, Lawrence Kuo, Steve Beck, Joan Zugay Murphy, Constantine Kreatsoulas, Justin T. Steen, Sanjeev Munshi, Carolyn A. Buser, Weikang Tao, Shaei Huang, Youwei Yan, V V Sardana, Bob Drakas, Mari Ikuta, James Hardwick, Keith W. Rickert, Mark E. Fraley, Elizabeth Mahan, Xianzhi Mao, Rob Lobell, Michael Reilly
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:5907-5912
Through a comparison of X-ray co-crystallographic data for 1 and 2 in the Chek1 active site, it was hypothesized that the affinity of the indolylquinolinone series (2) for Chek1 kinase would be improved via C6 substitution into the hydrophobic region
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9417e1526f4bd74048baad5244ad1fea
https://doi.org/10.1016/j.bmcl.2006.08.053
https://doi.org/10.1016/j.bmcl.2006.08.053
Autor:
James Z. Deng, S. D. Lewis, P.M. Rabbat, Craig A. Coburn, Terry A. Lyle, J. P. Vacca, Bobby J. Lucas, Daniel R. McMasters, Julie A. Krueger, B. Strulovici, Youwei Yan, Peter D. Williams, Lawrence Kuo, Christopher S. Burgey
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:4411-4416
Thrombin-inhibitor X-ray crystal structures, in combination with the installation of binding elements optimized within the pyrazinone series of thrombin inhibitors, were utilized to transform a weak triazolopyrimidine lead into a series of potent oxa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1043fcace9743b215fcb917a262ed643
https://doi.org/10.1016/j.bmcl.2005.07.022
https://doi.org/10.1016/j.bmcl.2005.07.022
Autor:
Robinson Kyle A, Terry A. Lyle, Audrey A. Wallace, Christina L. Newton, Zhongguo Chen, James Z. Deng, Cynthia Miller-Stein, Bobby J. Lucas, Daniel R. McMasters, Janetta M. Pellicore, Harold G. Selnick, Joseph J. Lynch, Rebecca B. White, Lawrence Kuo, Julie A. Krueger, Christopher S. Burgey, Bradley K. Wong, Youwei Yan, Joseph P. Vacca, S. Dale Lewis, Jules A. Shafer, Stephen J. Gardell, Philippe G. Nantermet
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:2771-2775
In this study, we have demonstrated that the critical hydrogen bonding motif of the established 3-aminopyrazinone thrombin inhibitors can be effectively mimicked by a 2-aminopyridine N-oxide. As this peptidomimetic core is more resistant toward oxida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aef44dc180ef4edd6ed211a2de81f5d
https://doi.org/10.1016/j.bmcl.2005.03.110
https://doi.org/10.1016/j.bmcl.2005.03.110
Autor:
Christopher S. Burgey, Joseph J. Lynch, Bobby J. Lucas, Lawrence Kuo, Dennis L. Bohn, Jules A. Shafer, Bradley K. Wong, Rominder Singh, Janetta M. Pellicore, Cynthia Miller-Stein, Audrey A. Wallace, Franklin C. Clayton, Stephen J. Gardell, Terry A. Lyle, Maria T. Stranieri, Denise C. Welsh, Daniel R. McMasters, Philippe G. Nantermet, Elizabeth A. Lyle, Harold G. Selnick, Joseph P. Vacca, Zhongguo Chen, Jacquelynn J. Cook, Rebecca B. White, Youwei Yan, Richard C.A. Isaacs, Julie A. Krueger, S. Dale Lewis, Swati Pal, Robinson Kyle A
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1353-1357
In this manuscript we demonstrate that a modification principally directed toward the improvement of the aqueous solubility (i.e., introduction a P3 pyridine N-oxide) of the previous lead compound afforded a new series of potent orally bioavailable P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86761c4103d6d5840c1ab409f42a991c
https://doi.org/10.1016/s0960-894x(03)00099-4
https://doi.org/10.1016/s0960-894x(03)00099-4
Autor:
Bobby J. Lucas, Franklin C. Clayton, Daniel R. McMasters, James C. Barrow, Peter D. Williams, Robinson Kyle A, Theodore J. Detwiler, Yvonne M. Leonard, Sanderson Philip E, Julie A. Krueger, S. Dale Lewis, Rebecca B. White, Elizabeth A. Lyle, Cynthia Miller-Stein, William M. Sanders, Marie A. Holahan, Colleen M. McDonough, Youwei Yan, Jacquelynn J. Cook, Maria T. Stranieri, Joseph J. Lynch, Rominder Singh, G. R. Sitko, Lawrence Kuo, Terry A. Lyle, Craig A. Coburn, Zhongguo Chen, Dennis L. Bohn, Jules A. Shafer, Joseph P. Vacca, Audrey A. Wallace, Bruce D. Dorsey, Bradley K. Wong, Christopher S. Burgey, Stephen J. Gardell
Publikováno v:
Journal of Medicinal Chemistry. 46:461-473
Recent efforts in the field of thrombin inhibitor research have focused on the identification of compounds with good oral bioavailability and pharmacokinetics. In this manuscript we describe a metabolism-based approach to the optimization of the 3-(2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b71ae0f7cadc2d662f0bc27e7e4d8c72
https://doi.org/10.1021/jm020311f
https://doi.org/10.1021/jm020311f
Autor:
Youwei Yan, Mohinder K. Sardana, C. Steinkuehler, Ying Li, Lawrence Kuo, R. De Francesco, Zhongguo Chen, Licia Tomei, Sanjeev Munshi, V V Sardana, James L. Cole
Publikováno v:
Protein Science. 7:837-847
The crystal structure of the NS3 protease of the hepatitis C virus (BK strain) has been determined in the space group P6(3)22 to a resolution of 2.2 A. This protease is bound with a 14-mer peptide representing the central region of the NS4A protein.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::517d36d00d31b6aa0dc5f782e63129ac
https://doi.org/10.1002/pro.5560070402
https://doi.org/10.1002/pro.5560070402
Autor:
Chris Culberson, Dawn L. Hall, Lawrence Kuo, Jules A. Shafer, Paul L. Darke, Zhongguo Chen, Ying Li, Elizabeth Chen
Publikováno v:
Journal of Biological Chemistry. 269:26344-26348
L-735,524 is a potent, orally bioavailable inhibitor of human immunodeficiency virus (HIV) protease currently in a Phase II clinical trial. We report here the three-dimensional structure of L-735,524 complexed to HIV-2 protease at 1.9-A resolution, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::531dde7294b6e4098a1dcc9c56dabadd
https://doi.org/10.1016/s0021-9258(18)47199-2
https://doi.org/10.1016/s0021-9258(18)47199-2