Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Lawrence Kolaczkowski"'
Autor:
Thaddeus S. Franczyk, Lawrence Kolaczkowski, James C. Marek, Donna K. Montavon, Maureen A. McLaughlin, Guangxin Liang, Anthony R. Haight, Vincent S. Chan, Travis B. Dunn, John E. Hengeveld, David M. Barnes, Jufang Barkalow, Shashank Shekhar, Brian J. Kotecki, James J. Napier
Publikováno v:
The Journal of Organic Chemistry. 84:4873-4892
Dasabuvir (1) is an HCV polymerase inhibitor which has been developed as a part of a three-component direct-acting antiviral combination therapy. During the course of the development of the synthetic route, two novel coupling reactions were developed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4480abb41d78d62bf0806f7dbbc334b
https://doi.org/10.1021/acs.joc.8b02690
https://doi.org/10.1021/acs.joc.8b02690
Autor:
Wayne A. Pritts, Anthony R. Haight, Lawrence Kolaczkowski, Jufang Barkalow, David M. Barnes, Adam Schellinger
Publikováno v:
The Journal of organic chemistry. 84(8)
( R)-Boc-2-methylproline (3a) was synthesized in good yield with excellent stereochemical control from alanine benzyl ester hydrochloride 11. The process, which is based on a modification of one described by Kawabata, proceeds in four steps and requi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7305fef7ed348f47cdfb2e8099679977
https://pubmed.ncbi.nlm.nih.gov/30716275
https://pubmed.ncbi.nlm.nih.gov/30716275
Autor:
Patel Ketan M, Jien-Heh J. Tien, Lawrence Kolaczkowski, Joseph B. Paterson, Arthur J. Cooper, and Peter J. Stengel, Jih-Hua Liu, Daniel J. Plata, Patricia A. Oliver-Shaffer, David A. Riley, Daniel A. Dickman, H. L. Sham, Eric J. Stoner, John E. Lallaman
Publikováno v:
Organic Process Research & Development. 4:264-269
A large scale process for the synthesis of HIV protease inhibitor candidate ABT-378 has been developed which utilizes an intermediate common to the synthesis of ritonavir, Abbott's first generation compound. The synthesis relies on the sequential acy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83ee1d1cf451e53c6ebab1944c57cf71
https://doi.org/10.1021/op990202j
https://doi.org/10.1021/op990202j
Autor:
Calvin L, Becker, Jean Christophe, Califano, John C, Tolle, James J, Napier, Lawrence, Kolaczkowski, Sou-Jen, Chang, Zhenping, Tian, Sukamar, Manna
Publikováno v:
Advances in experimental medicine and biology. 611
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c04eabe0c4f1332d96c467ef75310921
https://pubmed.ncbi.nlm.nih.gov/19400320
https://pubmed.ncbi.nlm.nih.gov/19400320
Autor:
Jean Christophe Califano, Sou-Jen Chang, Zhenping Tian, Sukamar Manna, Calvin L. Becker, John C. Tolle, Lawrence Kolaczkowski, J. J. Napier
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9780387736563
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb79454557ead9723c65d662aad5525a
https://doi.org/10.1007/978-0-387-73657-0_253
https://doi.org/10.1007/978-0-387-73657-0_253
Autor:
Lawrence Kolaczkowski, David M. Barnes
Publikováno v:
Organic letters. 9(16)
To extend the memory of chirality (MOC) methodology to structurally more diverse compounds, the synthesis of 4-hydroxy-alpha-methylprolines was undertaken. Yield and selectivity were very good, with an unexpected reversal in selectivity observed for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d4932fd5c4ca9942503f98e953edb89
https://pubmed.ncbi.nlm.nih.gov/17628068
https://pubmed.ncbi.nlm.nih.gov/17628068
Autor:
Fabio Palazzo, William J. Sanders, Phillip Hajduk, Richard R. Lesniewski, Jieyi Wang, Lawrence Kolaczkowski, Anil Vasudevan, Chang H. Park, Edward T. Olejniczak, Scott A. Erickson, Jason S. Tedrow, Qian Zhang, Gary T. Wang, Steve D. Fidanze, Robert A. Mantei, David G. Nettesheim, Pingping Lou, Steven K. Davidsen, Lora Tucker-Garcia, Andrew M. Petros, George S. Sheppard, Nwe Y. Bamaung, Ki H. Kim, David M. Barnes, Randy L. Bell, Megumi Kawai, David C. Park, Jack Henkin
Publikováno v:
Journal of medicinal chemistry. 49(13)
Methionine aminopeptidase-2 (MetAP2) is a novel target for cancer therapy. As part of an effort to discover orally active reversible inhibitors of MetAP2, a series of anthranilic acid sulfonamides with micromolar affinities for human MetAP2 were iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bbe5aaee196a4b7961d88b4f44816e1
https://pubmed.ncbi.nlm.nih.gov/16789740
https://pubmed.ncbi.nlm.nih.gov/16789740
Autor:
Lawrence Kolaczkowski, David M. Barnes
Publikováno v:
Organic Letters; Aug2007, Vol. 9 Issue 16, p3029-3032, 4p
Autor:
Lawrence Kolaczkowski, William Reusch
Publikováno v:
The Journal of Organic Chemistry. 50:4766-4771
On construit le squelette euphane par addition Diels Alder A+CD suivie d'une photoepimerisation en C-10 en 2 etapes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba52231f032ba32d70d46791ff214c8a
https://doi.org/10.1021/jo00224a022
https://doi.org/10.1021/jo00224a022