Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Lawrence J. Wilson"'
Autor:
Zheng Zhou, Jia Guo, Brian Hetrick, Sameer Tiwari, Amrita Haikerwal, Yang Han, Vincent C Bond, Ming B Huang, Marie K Mankowski, Beth A Snyder, Priscilla A Hogan, Savita K Sharma, Dennis C Liotta, Terry-Elinor Reid, Lawrence J Wilson, Yuntao Wu
Publikováno v:
PLoS Pathogens, Vol 20, Iss 8, p e1012448 (2024)
The chemokine co-receptors CXCR4 and CCR5 mediate HIV entry and signal transduction necessary for viral infection. However, to date only the CCR5 antagonist maraviroc is approved for treating HIV-1 infection. Given that approximately 50% of late-stag
Externí odkaz:
https://doaj.org/article/876c83ec1d1e47f8a72082ba070ecf97
Autor:
Lynnea D. Harris, Michael C. Regan, Scott J. Myers, Kelsey A. Nocilla, Nicholas S. Akins, Yesim A. Tahirovic, Lawrence J. Wilson, Ray Dingledine, Hiro Furukawa, Stephen F. Traynelis, Dennis C. Liotta
Publikováno v:
ACS Chemical Neuroscience. 14:917-935
Autor:
George W. Koszalka, Kamalesh P. Ruppa, Polina Lyuboslavsky, David S. Menaldino, Raymond Dingledine, Dennis C. Liotta, Stephen F. Traynelis, Zackery W. Dentmon, Lawrence J. Wilson, Scott J. Myers, Robert Zaczek, Yesim Altas Tahirovic
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 379:41-52
We describe a clinical candidate molecule from a new series of glutamate N-methyl-d-aspartate receptor subunit 2B-selective inhibitors that shows enhanced inhibition at extracellular acidic pH values relative to physiologic pH. This property should r
Autor:
Edgars Jecs, Yesim A. Tahirovic, Robert J. Wilson, Eric J. Miller, Michelle Kim, Valarie Truax, Huy H. Nguyen, Nicholas S. Akins, Manohar Saindane, Tao Wang, Chi S. Sum, Mary E. Cvijic, Gretchen M. Schroeder, Samantha L. Burton, Cynthia A. Derdeyn, Lingjie Xu, Yi Jiang, Lawrence J. Wilson, Dennis C. Liotta
Publikováno v:
Journal of medicinal chemistry. 65(5)
Our first-generation CXCR4 antagonist TIQ15 was rationally modified to improve drug-like properties. Introducing a nitrogen atom into the aromatic portion of the tetrahydroisoquinoline ring led to several heterocyclic variants including the 5,6,7,8-t
Autor:
Chi S. Sum, Yi Jiang, Yesim Altas Tahirovic, Lingjie Xu, Dennis C. Liotta, Michelle B. Kim, Nicholas S. Akins, Lawrence J. Wilson, Huy Nguyen, Mary Ellen Cvijic, Gretchen M. Schroeder, Tao Wang, Valarie M. Truax, Robert Wilson, Eric J. Miller, Edgars Jecs
Publikováno v:
ACS Med Chem Lett
[Image: see text] This work surveys a variety of diamino-heterocycles as an isosteric replacement for the piperazine substructure of our previously disclosed piperarinyl-tetrahydroisoquinoline containing CXCR4 antagonists. A late-stage Buchwald coupl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd15efbdf4f13c7f5fae15f6ab98bdb6
https://europepmc.org/articles/PMC8521655/
https://europepmc.org/articles/PMC8521655/
Autor:
Scott J, Myers, Kamalesh P, Ruppa, Lawrence J, Wilson, Yesim A, Tahirovic, Polina, Lyuboslavsky, David S, Menaldino, Zackery W, Dentmon, George W, Koszalka, Robert, Zaczek, Raymond J, Dingledine, Stephen F, Traynelis, Dennis C, Liotta
Publikováno v:
J Pharmacol Exp Ther
We describe a clinical candidate molecule from a new series of glutamate N-methyl-d-aspartate receptor subunit 2B–selective inhibitors that shows enhanced inhibition at extracellular acidic pH values relative to physiologic pH. This property should
Autor:
Edgars Jecs, Savita Sharma, Yesim Altas Tahirovic, Dennis C. Liotta, Sameshnee Pelly, Lawrence J. Wilson, Eric J. Miller
Publikováno v:
Expert opinion on therapeutic patents. 30(2)
Introduction: The chemokine receptor CXCR4 has been under intense study due to the central role it plays in immune system regulation and the pathology of many human diseases. The FDA approval of the first CXCR4 antagonist drug Plerixafor (i.e. AMD310
Autor:
Chi S. Sum, Christopher J. Butch, Lawrence J. Wilson, Katie M. Kuo, Michelle B. Kim, Yesim Altas Tahirovic, Mary Ellen Cvijic, Huy Nguyen, Dennis C. Liotta, Tao Wang, Robert Wilson, Valarie M. Truax, Eric J. Miller, Gretchen M. Schroeder, Edgars Jecs
Publikováno v:
Journal of Medicinal Chemistry. 61:7168-7188
CXCR4 is a G-protein-coupled receptor that interacts with its cognate ligand, CXCL12, to synchronize many physiological responses and pathological processes. Disruption of the CXCL12-CXCR4 circuitry by small-molecule antagonists has emerged as a prom
Autor:
Mary Ellen Cvijic, Katie M. Kuo, Chi S. Sum, Lawrence J. Wilson, Tao Wang, Yesim Altas Tahirovic, Valarie M. Truax, Eric J. Miller, Michelle B. Kim, Robert Wilson, Dennis C. Liotta, Gretchen M. Schroeder, Edgars Jecs, Huy Nguyen
Publikováno v:
ACS Medicinal Chemistry Letters. 9:446-451
[Image: see text] A novel series of CXCR4 antagonists with piperidinyl and piperazinyl alkylamine side chains designed as butyl amine replacements are described. Several of these compounds showed similar activity to the parent compound TIQ-15 (5) in
Autor:
Vincent C. Bond, Anthony R. Prosser, Ming-Bo Huang, Valarie M. Truax, Dennis C. Liotta, Kyle E. Giesler, Brooke M Katzman, Lawrence J. Wilson
Publikováno v:
Oncotarget
The chemokine receptor CXCR4 plays an integral role in the development of highly metastatic breast cancer and in the pathogenesis of chronic HIV infection. In this study, we compared the effects of CXCR4 antagonists on apoptosis induction in hematopo