Zobrazeno 1 - 10
of 483
pro vyhledávání: '"Lawrence J. Lesko"'
Autor:
Sarah Kim, Gezim Lahu, Majid Vakilynejad, Theodoros G. Soldatos, David B. Jackson, Lawrence J. Lesko, Mirjam N. Trame
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 6, Pp 1430-1438 (2022)
Abstract Immunotherapy became a key pillar of cancer therapeutics with the approvals of ipilimumab, nivolumab, and pembrolizumab, which inhibit either cytotoxic T‐lymphocyte antigen‐4 (CTLA‐4) or programmed death‐1 (PD‐1) that are negative
Externí odkaz:
https://doaj.org/article/a607a965adfe4884aaeb1f906224d781
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 5, Pp 540-555 (2022)
Abstract Promising drug development efforts may frequently fail due to unintended adverse reactions. Several methods have been developed to analyze such data, aiming to improve pharmacovigilance and drug safety. In this work, we provide a brief revie
Externí odkaz:
https://doaj.org/article/95b8a7dc745d43a8aa8d81832ba7b1ac
Autor:
Sarah Kim, Gezim Lahu, Majid Vakilynejad, Theodoros G. Soldatos, David B. Jackson, Lawrence J. Lesko, Mirjam N. Trame
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 4, Pp 1003-1013 (2022)
Abstract Adverse drug reactions (ADRs) of targeted therapy drugs (TTDs) are frequently unexpected and long‐term toxicities detract from exceptional efficacy of new TTDs. In this proof‐of‐concept study, we explored how molecular causation involv
Externí odkaz:
https://doaj.org/article/e711e5a0ce924ace851b9ad5a5cd0461
Autor:
Lawrence J. Lesko
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 10, Pp 1127-1129 (2021)
Model‐informed drug development (MIDD) is a process intended to expedite drug development, enhance regulatory science, and produce benefits for patients. Quantitative modeling and simulation—principally by population pharmacokinetics (PK), exposu
Externí odkaz:
https://doaj.org/article/16f7cd00602a48808417bdceaf78c622
Autor:
Nashid Farhan, Rodrigo Cristofoletti, Sumit Basu, Sarah Kim, Karthik Lingineni, Sibo Jiang, Joshua D. Brown, Lanyan (Lucy) Fang, Lawrence J. Lesko, Stephan Schmidt
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 3, Pp 199-210 (2021)
Abstract The exposure‐response relationship of direct acting oral anti‐coagulants (DOACs) for bleeding risk is steep relative to ischemic stroke reduction. As a result, small changes in exposure may lead to bleeding events. The overall goal of th
Externí odkaz:
https://doaj.org/article/65b7b9c93afe4b8798d1ebe130028b67
Publikováno v:
Cells, Vol 12, Iss 1, p 57 (2022)
Despite potent anticancer activity, the clinical utilization of cisplatin is limited due to nephrotoxicity. As Organic Cation Transporter 2 (OCT2) has been shown to be one of the key transporters involved in the uptake of cisplatin into renal proxima
Externí odkaz:
https://doaj.org/article/613df0fd81784305935cdebd815a063a
Autor:
Sonja Hartmann, Konstantinos Biliouris, Lawrence J. Lesko, Ulrike Nowak-Göttl, Mirjam N. Trame
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
BackgroundTight monitoring of efficacy and safety of anticoagulants such as warfarin is imperative to optimize the benefit-risk ratio of anticoagulants in patients. The standard tests used are measurements of prothrombin time (PT), usually expressed
Externí odkaz:
https://doaj.org/article/8088e21d941444d8a56e1110db34ffb9
Autor:
Konstantinos Biliouris, Puneet Gaitonde, Wei Yin, Daniel A. Norris, Yanfeng Wang, Scott Henry, Robert Fey, Ivan Nestorov, Stephan Schmidt, Mark Rogge, Lawrence J. Lesko, Mirjam N. Trame
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 7, Iss 9, Pp 581-592 (2018)
A pharmacokinetic (PK) model was developed for nusinersen, an antisense oligonucleotide (ASO) that is the first approved treatment for spinal muscular atrophy (SMA). The model was built with data from 92 nonhuman primates (NHPs) following intrathecal
Externí odkaz:
https://doaj.org/article/b2b051a9f867456392cdfdba33f08ea2
Autor:
Ahmed Elmokadem, Eric Burroughs Jordie, Conrad Housand, Christopher D. Bruno, Christina R. Chow, Lawrence J. Lesko, David J. Greenblatt
Publikováno v:
The Journal of Clinical Pharmacology. 62:66-75
Brexpiprazole is an oral antipsychotic agent indicated for use in patients with schizophrenia, or as adjunctive treatment for major depressive disorder. As cytochrome P450 (CYP) 2D6 contributes significantly to brexpiprazole metabolism, there is a la
Autor:
Sumit Basu, Sibo Jiang, Lanyan Lucy Fang, Rodrigo Cristofoletti, Nashid Farhan, Karthik Lingineni, Joshua D. Brown, Stephan Schmidt, Lawrence J. Lesko, Sarah Kim
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 3, Pp 199-210 (2021)
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 3, Pp 199-210 (2021)
The exposure‐response relationship of direct acting oral anti‐coagulants (DOACs) for bleeding risk is steep relative to ischemic stroke reduction. As a result, small changes in exposure may lead to bleeding events. The overall goal of this projec