Výsledky vyhledávání - "Lawrence J. Lambrecht"

Comparative pharmacokinetic analysis of USL255, a new once-daily extended-release formulation of topiramate

Autor: Mark Halvorsen, Lawrence J. Lambrecht, Tawfeeq Shekh-Ahmad, Meir Bialer, Wesley Todd

Publikováno v: Epilepsia. 52:1877-1883

Summary Purpose: To compare the pharmacokinetics of USL255, a once-daily extended-release (ER) formulation of topiramate (TPM), with Topamax (immediate-release TPM) in healthy subjects after oral dosing and evaluate the effect of food on USL255 bioav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6bb4ecdc4c660686040db14f349f07f7
https://doi.org/10.1111/j.1528-1167.2011.03183.x

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Transdermal estradiol gel 0.1% for the treatment of vasomotor symptoms in postmenopausal women

Autor: Ronald T Ackerman, Richard E Hedrick, William D. Koltun, Mark Halvorsen, Lawrence J. Lambrecht

Publikováno v: Menopause. 16:132-140

Objective The objective of this study was to evaluate the efficacy and safety of three doses of estradiol gel 0.1% (Divigel, a novel formulation consisting of 1 mg estradiol per 1 g transdermal gel) to reduce the frequency and severity of vasomotor s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1b5d479d0c5ea929a365a57740ed9e4
https://doi.org/10.1097/gme.0b013e31817d5372

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Pharmacokinetics of Pilocarpine in Subjects with Varying Degrees of Renal Function

Autor: Lawrence J. Lambrecht, Susan C. Gallagher, Suzanne K. Swan, Scott A. Andersen, John V. St. Peter, Brent W. Gunderson

Publikováno v: The Journal of Clinical Pharmacology. 40:1470-1475

Data from three separate single-center studies were combined to assess the pharmacokinetics of orally administered pilocarpine. Pilocarpine concentration-time data were used to generate a data set including 42 subjects (34 males, 8 females) with vary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e11fff2cb5356bcf10cb070a2f7b294a
https://doi.org/10.1177/009127000004001218

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Comparison of Anticoagulant Effects and Safety of Argatroban and Heparin in Healthy Subjects

Autor: Suzanne K. Swan, John V. St. Peter, Lawrence J. Lambrecht, Marcie J. Hursting

Publikováno v: Pharmacotherapy. 20:756-770

Study objective To evaluate and compare the relationship between dosage and coagulation parameters, as well as safety profiles, of ascending bolus and infusion dosages of argatroban versus heparin in three phase I studies. Design Two randomized, doub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33927027d29d01af5d33d4f6f6a89603
https://doi.org/10.1592/phco.20.9.756.35194

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Disposition of Recombinant Human Interleukin-10 in Subjects with Various Degrees of Renal Function

Autor: David L. Cutler, Scott R. Andersen, Melton B. Affrime, Elaine Radwanski, Jean-Jacques Garaud, Suzanne K. Swan, Lawrence J. Lambrecht

Publikováno v: The Journal of Clinical Pharmacology. 39:1015-1020

The pharmacokinetics of intravenously administered recombinant human interleukin-10 (rHuIL-10) were evaluated in 18 subjects with creatinine clearances (Clcr) between 2.7 and 116.7 mL/min/1.73 m2. Serum samples for rHuIL-10 were obtained over a 48-ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b4abd652dbf3dc3119ee07becf0a8fc
https://doi.org/10.1177/00912709922011773

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The effects of fenoldopam, a selective dopamine receptor agonist, on systemic and renal hemodynamics in normotensive subjects

Autor: Suzanne K. Swan, Dawn McGuire, Jere Fellmann, Lawrence J. Lambrecht, Shakeel Anjum, Robert R. Luther, Murray Epstein, Vandana Mathur

Publikováno v: Critical Care Medicine. 27:1832-1837

OBJECTIVE Acute renal failure, frequently a consequence of renal vasoconstriction and subsequent renal ischemia, is a common problem for which no proven preventive or therapeutic agents exist. Fenoldopam is a new, selective, dopamine-1 receptor agoni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de2e86b10cb93b1d0f0e0a67661230da
https://doi.org/10.1097/00003246-199909000-00021

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Pharmacokinetics, safety, and tolerability of gadoversetamide injection (OptiMARK) in subjects with central nervous system or liver pathology and varying degrees of renal function

Autor: William H. Barr, James F. Baker, Gary R. Stevens, Joseph A. Pierro, Lawrence J. Lambrecht, Suzanne K. Swan, Richard G. Barr, Steve Seltzer, Richard Free, Bruce J. Barron, Richard M. Tucker, G. Scott Gazelle, Kenneth R. Maravilla

Publikováno v: Journal of Magnetic Resonance Imaging. 9:317-321

The pharmacokinetic parameters, safety, and tolerability of OptiMARK (gadoversetamide injection), a gadolinium-based magnetic resonance imaging (MRI) contrast agent, were evaluated in 163 subjects with either central nervous system (CNS) or liver pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8287c18fd598f7ce5f2428577b5d6407
https://doi.org/10.1002/(sici)1522-2586(199902)9:2<317::aid-jmri25>3.0.co

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Pharmacokinetics of flutamide in patients with renal insufficiency

Autor: S Anjum, D. L. Cutler, M.B. Affrime, Lawrence J. Lambrecht, Elaine Radwanski, Suzanne K. Swan, C E Halstenson

Publikováno v: British Journal of Clinical Pharmacology. 47:43-47

Aims The aim of this study was to determine the pharmacokinetic parameters of flutamide, a nonsteroidal antiandrogenic compound, and its pharmacologically active metabolite, hydroxyflutamide, in renal insufficiency. Haemodialysis (HD) clearance of fl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc7e1f4d6ad339acc92a54a5cdd76ae
https://doi.org/10.1046/j.1365-2125.1999.00831.x

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