Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Lawrence J. Hayward"'
Autor:
Sujatha Jagannathan, Jessica C. de Greef, Lawrence J. Hayward, Kyoko Yokomori, Davide Gabellini, Karlien Mul, Sabrina Sacconi, Jamshid Arjomand, June Kinoshita, Scott Q. Harper
Publikováno v:
Skeletal Muscle, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Facioscapulohumeral muscular dystrophy (FSHD) is the second most common genetic myopathy, characterized by slowly progressing and highly heterogeneous muscle wasting with a typical onset in the late teens/early adulthood [1]. Although the et
Externí odkaz:
https://doaj.org/article/e1293d0484d644569819137cb3f35b3b
Publikováno v:
Cells, Vol 11, Iss 4, p 687 (2022)
Facioscapulohumeral muscular dystrophy (FSHD) is a debilitating muscular dystrophy with a variable age of onset, severity, and progression. While there is still no cure for this disease, progress towards FSHD therapies has accelerated since the under
Externí odkaz:
https://doaj.org/article/06079d95e9424a85a522ac4b857842b1
Autor:
Marie-Cécile Didiot, Chantal M. Ferguson, Socheata Ly, Andrew H. Coles, Abigail O. Smith, Alicia A. Bicknell, Lauren M. Hall, Ellen Sapp, Dimas Echeverria, Athma A. Pai, Marian DiFiglia, Melissa J. Moore, Lawrence J. Hayward, Neil Aronin, Anastasia Khvorova
Publikováno v:
Cell Reports, Vol 24, Iss 10, Pp 2553-2560.e5 (2018)
Summary: Huntington’s disease (HD) is a monogenic neurodegenerative disorder representing an ideal candidate for gene silencing with oligonucleotide therapeutics (i.e., antisense oligonucleotides [ASOs] and small interfering RNAs [siRNAs]). Using a
Externí odkaz:
https://doaj.org/article/a66fcac63b9e4812b1a982022c792c20
Autor:
Dongsheng Guo, Katelyn Daman, Jennifer JC Chen, Meng-Jiao Shi, Jing Yan, Zdenka Matijasevic, Amanda M Rickard, Monica H Bennett, Alex Kiselyov, Haowen Zhou, Anne G Bang, Kathryn R Wagner, René Maehr, Oliver D King, Lawrence J Hayward, Charles P Emerson Jr
Publikováno v:
eLife, Vol 11 (2022)
Skeletal muscle myoblasts (iMyoblasts) were generated from human induced pluripotent stem cells (iPSCs) using an efficient and reliable transgene-free induction and stem cell selection protocol. Immunofluorescence, flow cytometry, qPCR, digital RNA e
Externí odkaz:
https://doaj.org/article/9ecae599191e4bdc9b10049699fefb2c
Autor:
Katelyn Daman, Dongsheng Guo, Jennifer JC Chen, Meng-Jiao Shi, Jing Yan, Zdenka Matijasevic, Amanda M Rickard, Monica H Bennett, Alex Kiselyov, Haowen Zhou, Anne G Bang, Kathryn R Wagner, René Maehr, Oliver D King, Lawrence J Hayward, Charles P Emerson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b391c162ae6d9e4f68d0a2c4485d31d
https://doi.org/10.7554/elife.70341.sa2
https://doi.org/10.7554/elife.70341.sa2
Autor:
Dongsheng Guo, Katelyn Daman, Jennifer JC Chen, Meng-Jiao Shi, Jing Yan, Zdenka Matijasevic, Amanda M Rickard, Monica H Bennett, Alex Kiselyov, Haowen Zhou, Anne G Bang, Kathryn R Wagner, René Maehr, Oliver D King, Lawrence J Hayward, Charles P Emerson Jr
Publikováno v:
eLife
eLife, Vol 11 (2022)
eLife, Vol 11 (2022)
Skeletal muscle myoblasts (iMyoblasts) were generated from human induced pluripotent stem cells (iPSCs) using an efficient and reliable transgene-free induction and stem cell selection protocol. Immunofluorescence, flow cytometry, qPCR, digital RNA e
Autor:
Yen-Chen Lin, John D. Leszyk, Evangelos Kiskinis, John Landers, Salome Funes, Lawrence J. Hayward, Scott A. Shaffer, Maeve Tischbein, Kevin P. Kenna, Roy Parker, Tyler Matheny, Desiree M. Baron, Daryl A. Bosco, David Santos, Katherine V. Gall
Publikováno v:
Hum Mol Genet
Aberrant translational repression is a feature of multiple neurodegenerative diseases. The association between disease-linked proteins and stress granules further implicates impaired stress responses in neurodegeneration. However, our knowledge of th
Publikováno v:
The Journal of General Physiology
Hyperkalemic periodic paralysis (HyperKPP) manifests as stiffness or subclinical myotonic discharges before or during periods of episodic muscle weakness or paralysis. Ingestion of Ca2+ alleviates HyperKPP symptoms, but the mechanism is unknown becau
Autor:
Abigail O. Smith, Chantal M. Ferguson, Anastasia Khvorova, Ellen Sapp, Neil Aronin, Alicia A. Bicknell, Marie-Cecile Didiot, Marian DiFiglia, Dimas Echeverria, Socheata Ly, Lauren M Hall, Lawrence J. Hayward, Melissa J. Moore, Andrew H. Coles, Athma A. Pai
Publikováno v:
Cell Reports, Vol 24, Iss 10, Pp 2553-2560.e5 (2018)
Summary: Huntington’s disease (HD) is a monogenic neurodegenerative disorder representing an ideal candidate for gene silencing with oligonucleotide therapeutics (i.e., antisense oligonucleotides [ASOs] and small interfering RNAs [siRNAs]). Using a
Publikováno v:
The Journal of General Physiology
When muscles become paralyzed in crises of hyperkalemic periodic paralysis, patients do not stop breathing. Here is why.
The diaphragm muscle of hyperkalemic periodic paralysis (HyperKPP) patients and of the M1592V HyperKPP mouse model rarely su
The diaphragm muscle of hyperkalemic periodic paralysis (HyperKPP) patients and of the M1592V HyperKPP mouse model rarely su