Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Lawrence J. Thomas"'
Autor:
Michael B. Murphy, Laura Vitale, Shukai Xia, Zeyu Peng, Thomas O’Neill, Jay Lillquist, Anna Wasiuk, Jeff Weidlick, Jenifer Widger, Laura Mills-Chen, Andrea Crocker, Colleen Patterson, James Boyer, April R. Baronas, Mingjiu Chen, Hugh M. Davis, Mark Ma, Joel Goldstein, Lawrence J. Thomas, Diego Alvarado, Henry C. Marsh, Tibor Keler
Publikováno v:
Immuno, Vol 3, Iss 3, Pp 273-288 (2023)
Immunoglobulin-like transcript 4 (ILT4) is an immunosuppressive molecule predominantly expressed on myeloid cells. Recent studies combining ILT4 suppression with programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) blockade have show
Externí odkaz:
https://doaj.org/article/e24496d39a404eb1a00b6ba38c57bbb8
Autor:
Dharmendra Kumar Soni, Vidya P. Kumar, Shukla Biswas, Gregory P. Holmes-Hampton, Sharmistha Bhattacharyya, Lawrence J. Thomas, Roopa Biswas, Sanchita P. Ghosh
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 30, Iss , Pp 569-584 (2022)
Risks of radiation exposure necessitate the development of radioprophylactic drugs. We have reported the efficacy of CDX-301, a recombinantly developed human protein form of Fms-related tyrosine kinase 3 ligand (Flt3L), as a radioprophylactic and rad
Externí odkaz:
https://doaj.org/article/a9d69ae6fab54273a63cbf87c390239d
Autor:
Dorothea Terhorst‐Molawi, Tomasz Hawro, Eva Grekowitz, Lea Kiefer, Kunal Merchant, Diego Alvarado, Lawrence J. Thomas, Thomas Hawthorne, Elizabeth Crowley, Margo Heath‐Chiozzi, Martin Metz, Marcus Maurer
Publikováno v:
Allergy. 78:1269-1279
Chronic inducible urticaria (CIndU) is characterized by mast cell (MC)-mediated wheals in response to triggers: cold in cold urticaria (ColdU) and friction in symptomatic dermographism (SD). KIT receptor activation by stem cell factor (SCF) is essent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e14c935b8d21a5a572591f678511c74a
https://doi.org/10.1111/all.15585
https://doi.org/10.1111/all.15585
Autor:
Keler, Michael B. Murphy, Laura Vitale, Shukai Xia, Zeyu Peng, Thomas O’Neill, Jay Lillquist, Anna Wasiuk, Jeff Weidlick, Jenifer Widger, Laura Mills-Chen, Andrea Crocker, Colleen Patterson, James Boyer, April R. Baronas, Mingjiu Chen, Hugh M. Davis, Mark Ma, Joel Goldstein, Lawrence J. Thomas, Diego Alvarado, Henry C. Marsh, Tibor
Publikováno v:
Immuno; Volume 3; Issue 3; Pages: 273-288
Immunoglobulin-like transcript 4 (ILT4) is an immunosuppressive molecule predominantly expressed on myeloid cells. Recent studies combining ILT4 suppression with programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) blockade have show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::b5f2803238c22a9bbaa83875b6fdb33e
Autor:
Murugesan V.S. Rajaram, Eusondia Arnett, Abul K. Azad, Evelyn Guirado, Bin Ni, Abigail D. Gerberick, Li-Zhen He, Tibor Keler, Lawrence J. Thomas, William P. Lafuse, Larry S. Schlesinger
Publikováno v:
Cell Reports, Vol 21, Iss 1, Pp 126-140 (2017)
Despite its prominent role as a C-type lectin (CTL) pattern recognition receptor, mannose receptor (MR, CD206)-specific signaling molecules and pathways are unknown. The MR is highly expressed on human macrophages, regulating endocytosis, phagocytosi
Externí odkaz:
https://doaj.org/article/5a0913fd2f82491fa5938f195a20e76c
Autor:
Tibor Keler, Henry C. Marsh, Andrea Crocker, Karuna Sundarapandiyan, Jenifer Widger, Russell A. Hammond, Catherine D. Pilsmaker, James R. Storey, James M. Boyer, Eric M. Forsberg, Lauren E. Gergel, Hans Minderman, Paul K. Wallace, Ree Y. Dolnick, Thomas O'Neill, Laura Vitale, Lawrence J. Thomas
Epitope mapping using overlapping TIM-1 fragments. A series of peptides from the amino acid sequence 209-222 of TIM-1 were synthesized and coated to plates to demonstrate direct binding by CDX-014 mAb.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34ef2f851dda5b47f9ea601b8b774f8c
https://doi.org/10.1158/1535-7163.22508622.v1
https://doi.org/10.1158/1535-7163.22508622.v1
Autor:
Tibor Keler, Henry C. Marsh, Andrea Crocker, Karuna Sundarapandiyan, Jenifer Widger, Russell A. Hammond, Catherine D. Pilsmaker, James R. Storey, James M. Boyer, Eric M. Forsberg, Lauren E. Gergel, Hans Minderman, Paul K. Wallace, Ree Y. Dolnick, Thomas O'Neill, Laura Vitale, Lawrence J. Thomas
Structure of CDX-014. CDX-014 is a fully human monoclonal antibody specific for TIM-1 covalently linked to the enzyme-cleavable valine-citrulline-p-aminobenzylcarbamate-monomethylauristatin-E (vcMMAE). The drug to antibody (DAR) molar ratio was appro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ae73207c29191e23654e5d1589c701d
https://doi.org/10.1158/1535-7163.22508625.v1
https://doi.org/10.1158/1535-7163.22508625.v1
Autor:
Diego Alvarado, Marcus Maurer, Richard Gedrich, Scott B. Seibel, Michael B. Murphy, Linda Crew, Joel Goldstein, Andrea Crocker, Laura A. Vitale, Pamela A. Morani, Lawrence J. Thomas, Thomas R. Hawthorne, Tibor Keler, Diane Young, Elizabeth Crowley, Martin Kankam, Margo Heath‐Chiozzi
Publikováno v:
Allergy. 77:2393-2403
Mast cells (MC) are powerful inflammatory immune sentinel cells that drive numerous allergic, inflammatory, and pruritic disorders when activated. MC-targeted therapies are approved in several disorders, yet many patients have limited benefit suggest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b83e55af5beb6cbb26e914b5749638d3
https://doi.org/10.1111/all.15262
https://doi.org/10.1111/all.15262
Autor:
Aymen Al-Shamkhani, Tibor Keler, Michael A. Curran, Li-Zhen He, Christine A. Penfold, Lawrence J. Thomas, Anne Rogel, Vadim Y. Taraban, Stephen M. Thirdborough, Mohannad Fallatah, Sarah L. Buchan
List of genes in clusters 3 and 4 with the greatest fold-changes between monotherapy and combination therapy groups
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1ecf5d98e0aa1195bb64a1029521e37
https://doi.org/10.1158/1078-0432.22464092
https://doi.org/10.1158/1078-0432.22464092
Autor:
Aymen Al-Shamkhani, Tibor Keler, Michael A. Curran, Li-Zhen He, Christine A. Penfold, Lawrence J. Thomas, Anne Rogel, Vadim Y. Taraban, Stephen M. Thirdborough, Mohannad Fallatah, Sarah L. Buchan
Purpose: PD-1 checkpoint blockade has revolutionized the field of cancer immunotherapy, yet the frequency of responding patients is limited by inadequate T-cell priming secondary to a paucity of activatory dendritic cells (DC). DC signals can be bypa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eea76d6421bd3b7528bc593d3913fdc
https://doi.org/10.1158/1078-0432.c.6525617
https://doi.org/10.1158/1078-0432.c.6525617