Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Lawrence J Dooling"'
Autor:
Brandon H Hayes, Mai Wang, Hui Zhu, Steven H Phan, Lawrence J Dooling, Jason C Andrechak, Alexander H Chang, Michael P Tobin, Nicholas M Ontko, Tristan Marchena, Dennis E Discher
Publikováno v:
eLife, Vol 12 (2024)
Solid tumors generally exhibit chromosome copy number variation, which is typically caused by chromosomal instability (CIN) in mitosis. The resulting aneuploidy can drive evolution and associates with poor prognosis in various cancer types as well as
Externí odkaz:
https://doaj.org/article/8b917f509d2c4d10a4dbad3350216fa9
Autor:
Charlotte R. Pfeifer, Michael P. Tobin, Sangkyun Cho, Manasvita Vashisth, Lawrence J. Dooling, Lizeth Lopez Vazquez, Emma G. Ricci-De Lucca, Keiann T. Simon, Dennis E. Discher
Publikováno v:
Nucleus, Vol 13, Iss 1, Pp 129-143 (2022)
Nuclear rupture has long been associated with deficits or defects in lamins, with recent results also indicating a role for actomyosin stress, but key physical determinants of rupture remain unclear. Here, lamin-B filaments stably interact with the n
Externí odkaz:
https://doaj.org/article/24f2d772cf1546849c968f505a41ab11
Autor:
Jason C. Andrechak, Lawrence J. Dooling, Michael P. Tobin, William Zhang, Brandon H. Hayes, Justine Y. Lee, Xiaoling Jin, Jerome Irianto, Dennis E. Discher
Publikováno v:
Cancers, Vol 14, Iss 8, p 1930 (2022)
The macrophage checkpoint interaction CD47-SIRPα is an emerging target for cancer therapy, but clinical trials of monoclonal anti-CD47 show efficacy only in liquid tumors when combined with tumor-opsonizing IgG. Here, in challenging metastatic solid
Externí odkaz:
https://doaj.org/article/1eda1536bd4f437b8d93508dbb58b289
Publikováno v:
Journal of Cell Biology. 222
The nucleus in many cell types is a stiff organelle, but fat-filled lipid droplets (FDs) in cytoplasm are seen to indent and displace the nucleus. FDs are phase-separated liquids with a poorly understood interfacial tension γ that determines how FDs
Autor:
Brandon H. Hayes, Peter Kuangzheng Zhu, Mai Wang, Charlotte R. Pfeifer, Yuntao Xia, Steven Phan, Jason C. Andrechak, Junhong Du, Michael P. Tobin, Alisya Anlas, Lawrence J. Dooling, Manasvita Vashisth, Jerome Irianto, Michael A. Lampson, Dennis E. Discher
Publikováno v:
Journal of Cell Science.
A cell's mechanical environment can have many effects, but whether it impacts a cell's DNA sequence has remained unclear. To investigate this, we developed a live-cell method to measure changes in chromosome numbers. We edited constitutive genes with
Autor:
Lawrence J. Dooling, Jason C. Andrechak, Brandon H. Hayes, Siddhant Kadu, William Zhang, Ruby Pan, Manasvita Vashisth, Jerome Irianto, Cory M. Alvey, Leyuan Ma, Dennis E. Discher
Publikováno v:
Nature Biomedical Engineering.
Autor:
Brandon H. Hayes, Mai Wang, Hui Zhu, Steven H. Phan, Jason C. Andrechak, Alexander H. Chang, Lawrence J. Dooling, Michael P. Tobin, Tristan Marchena, Dennis E. Discher
Chromosomal instability (CIN), a state in which cells undergo mitotic aberrations that generate chromosome copy number variations, generates aneuploidy and is thought to drive cancer evolution. Although associated with poor prognosis and reduced immu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::907b4a3f412774fd497bb849631b84c3
https://doi.org/10.1101/2023.04.02.535275
https://doi.org/10.1101/2023.04.02.535275
Autor:
Lawrence J. Dooling, David A. Tirrell
Publikováno v:
ACS Central Science, Vol 2, Iss 11, Pp 812-819 (2016)
Externí odkaz:
https://doaj.org/article/d4d28381ba714dfd879650c316e1bb89
Autor:
Olalekan H Usman, Sampath Kumar, Reddick R Walker, Gengqiang Xie, AbdelAziz R. Jalil, Subramanian Ramakrishnan, Lawrence J. Dooling, Yue Julia Wang, Jerome Irianto
Pancreatic cancer adenocarcinoma (PDAC) has been reported to be the third highest cause of cancer-related deaths in the United States. PDAC is known for its high proportion of stroma which accounts for 90% of the tumor mass. The stroma is made up of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d09e30d768ed99f3a6ff93229c70a31
https://doi.org/10.1101/2022.11.11.516201
https://doi.org/10.1101/2022.11.11.516201
The nucleus in many cell types is a stiff organelle, and yet fat-filled lipid droplets (FD’s) in the cytoplasm can be seen to indent and displace the nucleus. FD’s are phase-separated liquids with a poorly understood interfacial tension γ that d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8f2837ab50f6a39fdd1093e7d1e796a
https://doi.org/10.1101/2022.09.01.506190
https://doi.org/10.1101/2022.09.01.506190