Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Lawrence Harris"'
Autor:
Scott A. Cameron, Lawrence Harris, Arthur Laganowsky, Zahra Moghadamchargari, Dan Torres, James C. Sacchettini, Inna Krieger, Thomas D. Meek, Drake M. Mellott
Publikováno v:
Journal of the American Chemical Society. 143:17666-17676
The isocitrate lyase paralogs of Mycobacterium tuberculosis (ICL1 and 2) are essential for mycobacterial persistence and constitute targets for the development of antituberculosis agents. We report that (2R,3S)-2-hydroxy-3-(nitromethyl)succinic acid
Autor:
Andreas Luxenburger, Anthony David Woolhouse, Graeme J. Gainsford, Richard H. Furneaux, Chris D. Ling, Ross O. Piltz, Scott A. Cameron, Roselis A. Landaeta Aponte, Andrew R. Lewis, Lawrence Harris, Alex Weymouth-Wilson, Elizabeth M. Ure
Publikováno v:
ACS Omega, Vol 6, Iss 38, Pp 25019-25039 (2021)
ACS Omega
ACS Omega
Decoupling the roles of the farnesoid X nuclear receptor and Takeda G-protein-coupled bile acid receptor 5 is essential for the development of novel bile acid therapeutics targeting metabolic and neurodegenerative diseases. Herein, we describe the sy
Autor:
Vern L. Schramm, Mu Feng, Rajesh K. Harijan, Morais Brown, Lawrence Harris, Richard F.G. Fröhlich, Peter C. Tyler
Publikováno v:
Biochemistry. 60:1933-1946
Helicobacter pylori is a Gram-negative bacterium that is responsible for gastric and duodenal ulcers. H. pylori uses the unusual mqn pathway with aminofutalosine (AFL) as an intermediate for menaquinone biosynthesis. Previous reports indicate that hy
Autor:
Gary J. Gerfen, Ayala G. Carl, Mu Feng, Tyler L. Grove, Lars Ulrik Nordstrøm, Gary B. Evans, Steven C. Almo, Alexey Silakov, Lawrence Harris
Publikováno v:
Biochemistry. 59:2562-2575
Antibiotic resistance continues to spread at an alarming rate, outpacing the introduction of new therapeutics and threatening to globally undermine health care. There is a crucial need for new strategies that selectively target specific pathogens whi
Autor:
Pauline van Nies, Xiangzhi Meng, Lawrence Harris, Mona Seifert, Flavia S. Papini, Hongjie Xia, Jamie J. Arnold, Ashleigh Shannon, Subhas C. Bera, Tyler L. Grove, Bruno Canard, David Dulin, Robert N. Kirchdoerfer, Steven C. Almo, Craig E. Cameron, Martin Depken, Yan Xiang, James M. Wood, Pei Yong Shi, Thi Tuyet Nhung Le
Publikováno v:
eLife, 2021(10):e70968, 1-26. eLife Sciences Publications
eLife
eLife, Vol 10 (2021)
Seifert, M, Bera, S C, Van Nies, P, Kirchdoerfer, R N, Shannon, A, Le, T T N, Meng, X, Xia, H, Wood, J M, Harris, L D, Papini, F S, Arnold, J J, Almo, S, Grove, T L, Shi, P Y, Xiang, Y, Canard, B, Depken, M, Cameron, C E & Dulin, D 2021, ' Inhibition of sars-cov-2 polymerase by nucleotide analogs from a single-molecule perspective ', eLife, vol. 2021, no. 10, e70968, pp. 1-26 . https://doi.org/10.7554/eLife.70968
eLife, 10
bioRxiv
article-version (status) pre
article-version (number) 2
eLife
eLife, Vol 10 (2021)
Seifert, M, Bera, S C, Van Nies, P, Kirchdoerfer, R N, Shannon, A, Le, T T N, Meng, X, Xia, H, Wood, J M, Harris, L D, Papini, F S, Arnold, J J, Almo, S, Grove, T L, Shi, P Y, Xiang, Y, Canard, B, Depken, M, Cameron, C E & Dulin, D 2021, ' Inhibition of sars-cov-2 polymerase by nucleotide analogs from a single-molecule perspective ', eLife, vol. 2021, no. 10, e70968, pp. 1-26 . https://doi.org/10.7554/eLife.70968
eLife, 10
bioRxiv
article-version (status) pre
article-version (number) 2
The absence of ‘shovel-ready’ anti-coronavirus drugs during vaccine development has exceedingly worsened the SARS-CoV-2 pandemic. Furthermore, new vaccine-resistant variants and coronavirus outbreaks may occur in the near future, and we must be r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb8113a681cea990d5dd39b90a05094b
https://research.vu.nl/en/publications/d1a61e7d-93d0-4d77-a2d6-942d44eecad2
https://research.vu.nl/en/publications/d1a61e7d-93d0-4d77-a2d6-942d44eecad2
Autor:
Mona Seifert, Lawrence Harris, Robert N. Kirchdoerfer, Pei Yong Shi, Subhas C. Bera, James M. Wood, Steven C. Almo, Bruno Canard, Jamie J. Arnold, Xiangzhi Meng, Flavia S. Papini, Hongjie Xia, Martin Depken, Thi-Tuyet-Nhung Le, Craig E. Cameron, Ashleigh Shannon, Tyler L. Grove, Yan Xiang, David Dulin, Pauline van Nies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49ee81c10f1f3c472d7411d10bb51725
https://doi.org/10.7554/elife.70968.sa2
https://doi.org/10.7554/elife.70968.sa2
Autor:
Tyler L. Grove, Scott A. Cameron, James M. Wood, Richard H. Furneaux, Gary B. Evans, Lawrence Harris, Steven C. Almo
Publikováno v:
The Journal of organic chemistry. 86(13)
3'-Deoxy-3',4'-didehydro-cytidine triphosphate (ddhCTP) is a novel antiviral molecule produced by the enzyme viperin as part of the innate immune response. ddhCTP has been shown to act as an obligate chain terminator of flavivirus and SARS-CoV-2 RNA-
Publikováno v:
SSRN Electronic Journal.
Autor:
Mona Seifert, Robert N. Kirchdoerfer, James M. Wood, Steven C. Almo, Flavia S. Papini, Xiangzhi Meng, Pei Yong Shi, Martin Depken, Lawrence Harris, Subhas C. Bera, Bruno Canard, Pauline van Nies, Yan Xiang, David Dulin, Thi-Tuyet-Nhung Le, Craig E. Cameron, Tyler L. Grove, Hongjie Xia, Ashleigh Shannon, Jamie J. Arnold
The nucleotide analog Remdesivir (RDV) is the only FDA-approved antiviral therapy to treat infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The physical basis for efficient utilization of RDV by SARS-CoV-2 polymerase is unkn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16acdbb78e4f1d0ae255b8b5344f47bd
https://doi.org/10.1101/2020.08.06.240325
https://doi.org/10.1101/2020.08.06.240325
Autor:
Krause, Kurt L., Richard Furneaux, Paul Benjes, Margaret Brimble, Tony Davidson, William Denny, Lawrence Harris, Simon Hinkley, Peter Tyler, Ussher, James E., Vernon Ward
Publikováno v:
Dimensions
COVID-19 will be with us through the remainder of 2020 and almost certainly beyond. New Zealand needs a viable strategy to protect its populace until a vaccine is developed and in wide use. Until that time, it makes sense to protect the population by