Zobrazeno 1 - 10
of 329
pro vyhledávání: '"Lawrence H. Boise"'
Autor:
Nisha S. Joseph, Jonathan L. Kaufman, Vilas A. Gupta, Craig C. Hofmeister, Madhav V. Dhodapkar, Lawrence H. Boise, Sara M. DiCamillo, Danielle Roberts, Ajay K. Nooka, Sagar Lonial
Publikováno v:
Blood Cancer Journal, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Lenalidomide, bortezomib, and dexamethasone (RVd) have previously been established as standard-of-care induction therapy for newly diagnosed multiple myeloma (NDMM). More recently, randomized phase 3 data have demonstrated the benefit of the
Externí odkaz:
https://doaj.org/article/1432d47c2a254b14a2b8cb6d5ae2f228
Autor:
M. Hope Robinson, Nancy Y. Villa, David L. Jaye, Ajay K. Nooka, Alyssa Duffy, Samuel S. McCachren, Julia Manalo, Jeffrey M. Switchenko, Sierra Barnes, Sayalee Potdar, Maryam I. Azeem, Ava A. Horvat, Vaunita C. Parihar, Jingjing Gong, Yan Liang, Geoffrey H. Smith, Vikas A. Gupta, Lawrence H. Boise, Jonathan L. Kaufman, Craig C. Hofmeister, Nisha S. Joseph, Sagar Lonial, Kavita M. Dhodapkar, Madhav V. Dhodapkar
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 15 (2023)
Entry of antigen-specific T cells into human tumors is critical for immunotherapy, but the underlying mechanisms are poorly understood. Here, we combined high-dimensional spatial analyses with in vitro and in vivo modeling to study the mechanisms und
Externí odkaz:
https://doaj.org/article/4e93c2e8320c4a29894d2dbcaa88a70f
Autor:
Vikas A. Gupta, Shannon M. Matulis, Benjamin G. Barwick, R. Devin Bog, Conrad W. Shebelut, Mala Shanmugam, Paola Neri, Nizar J. Bahlis, Madhav V. Dhodapkar, Leonard T. Heffner, Craig C. Hofmeister, Nisha S. Joseph, Sagar Lonial, Jonathan L. Kaufman, David L. Jaye, Ajay K. Nooka, Lawrence H. Boise
Publikováno v:
Blood Cancer Journal, Vol 12, Iss 8, Pp 1-4 (2022)
Externí odkaz:
https://doaj.org/article/b80806186ba7462e812a4322e8cf5287
Autor:
Jayeeta Ghose, Ada Dona, Mariam Murtadha, Emine Gulsen Gunes, Enrico Caserta, Ji Young Yoo, Luke Russell, Alena Cristina Jaime-Ramirez, Benjamin G. Barwick, Vikas A. Gupta, James F. Sanchez, Douglas W. Sborov, Steven T. Rosen, Amrita Krishnan, Lawrence H. Boise, Balveen Kaur, Craig C. Hofmeister, Flavia Pichiorri
Publikováno v:
Molecular Therapy: Oncolytics, Vol 20, Iss , Pp 519-531 (2021)
Because most patients with multiple myeloma (MM) develop resistance to current regimens, novel approaches are needed. Genetically modified, replication-competent oncolytic viruses exhibit high tropism for tumor cells regardless of cancer stage and pr
Externí odkaz:
https://doaj.org/article/65d17a0839584df484a779e3dc1740bf
Autor:
Yanyan Gu, Benjamin G. Barwick, Mala Shanmugam, Craig C. Hofmeister, Jonathan Kaufman, Ajay Nooka, Vikas Gupta, Madhav Dhodapkar, Lawrence H. Boise, Sagar Lonial
Publikováno v:
Blood Cancer Journal, Vol 10, Iss 12, Pp 1-10 (2020)
Abstract Protein homeostasis is critical for maintaining eukaryotic cell function as well as responses to intrinsic and extrinsic stress. The proteasome is a major portion of the proteolytic machinery in mammalian cells and plays an important role in
Externí odkaz:
https://doaj.org/article/6ff11ca5684d40f9b59e2f4a4be3c0cb
Autor:
Remya Nair, Vimal Subramaniam, Benjamin G. Barwick, Vikas A. Gupta, Shannon M. Matulis, Sagar Lonial, Lawrence H. Boise, Ajay K. Nooka, Kuzhali Muthumalaiappan, Mala Shanmugam
Publikováno v:
Haematologica, Vol 107, Iss 9 (2022)
Externí odkaz:
https://doaj.org/article/e555d024adbd48c9975863d16d1d2407
Autor:
Richa Bajpai, Aditi Sharma, Abhinav Achreja, Claudia L. Edgar, Changyong Wei, Arusha A. Siddiqa, Vikas A. Gupta, Shannon M. Matulis, Samuel K. McBrayer, Anjali Mittal, Manali Rupji, Benjamin G. Barwick, Sagar Lonial, Ajay K. Nooka, Lawrence H. Boise, Deepak Nagrath, Mala Shanmugam
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Venetoclax monotherapy is effective in 40% of t(11:14) positive multiple myeloma (MM). Here, the authors show that electron transport chain complex I (CI) and complex II (CII) activity predict MM sensitivity to venetoclax, and inhibition of CI with I
Externí odkaz:
https://doaj.org/article/ab542c51a366402d8b83cd98c687f243
Autor:
Yu-Hsiu T. Lin, Gregory P. Way, Benjamin G. Barwick, Margarette C. Mariano, Makeba Marcoulis, Ian D. Ferguson, Christoph Driessen, Lawrence H. Boise, Casey S. Greene, Arun P. Wiita
Publikováno v:
Blood Advances, Vol 3, Iss 21, Pp 3214-3227 (2019)
Abstract: A major driver of multiple myeloma (MM) is thought to be aberrant signaling, yet no kinase inhibitors have proven successful in the clinic. Here, we employed an integrated, systems approach combining phosphoproteomic and transcriptome analy
Externí odkaz:
https://doaj.org/article/b53652b0b02e43968b7e68a237b3e8f4
Autor:
Benjamin G. Barwick, Paola Neri, Nizar J. Bahlis, Ajay K. Nooka, Madhav V. Dhodapkar, David L. Jaye, Craig C. Hofmeister, Jonathan L. Kaufman, Vikas A. Gupta, Daniel Auclair, Jonathan J. Keats, Sagar Lonial, Paula M. Vertino, Lawrence H. Boise
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Multiple myeloma is frequently characterised by translocation of genes next to the immunoglobulin heavy chain locus. In this study, the authors sequence a large cohort of high risk myeloma samples and find translocations of cMyc to the immunoglobulin
Externí odkaz:
https://doaj.org/article/f7edb1aa7e034097bfaeab285876053f
Autor:
Adriana E. Tron, Matthew A. Belmonte, Ammar Adam, Brian M. Aquila, Lawrence H. Boise, Elisabetta Chiarparin, Justin Cidado, Kevin J. Embrey, Eric Gangl, Francis D. Gibbons, Gareth P. Gregory, David Hargreaves, J. Adam Hendricks, Jeffrey W. Johannes, Ricky W. Johnstone, Steven L. Kazmirski, Jason G. Kettle, Michelle L. Lamb, Shannon M. Matulis, Ajay K. Nooka, Martin J. Packer, Bo Peng, Philip B. Rawlins, Daniel W. Robbins, Alwin G. Schuller, Nancy Su, Wenzhan Yang, Qing Ye, Xiaolan Zheng, J. Paul Secrist, Edwin A. Clark, David M. Wilson, Stephen E. Fawell, Alexander W. Hird
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
High expression of Mcl-1 promotes tumorigenesis and resistance to anticancer therapies. Here they report a macrocyclic molecule with high selectivity and affinity for Mcl-1 that exhibits potent anti-tumor effects as single agent and in combination wi
Externí odkaz:
https://doaj.org/article/814ff3ef6b204d84917e2b025f3e1da9