Zobrazeno 1 - 10
of 156
pro vyhledávání: '"Lawrence H, Young"'
Autor:
Michael W. Rudokas, Margaret McKay, Zeren Toksoy, Julia N. Eisen, Markus Bögner, Lawrence H. Young, Fadi G. Akar
Publikováno v:
Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-14 (2024)
Abstract Mitochondria play a central role in cellular energy metabolism, and their dysfunction is increasingly recognized as a critical factor in the pathogenesis of diabetes-related cardiac pathophysiology, including vulnerability to ischemic events
Externí odkaz:
https://doaj.org/article/b2f397b4ab4b47cc82c3cdc543d7e8d2
Autor:
Evangelos K. Oikonomou, Phyllis M. Thangaraj, Deepak L. Bhatt, Joseph S. Ross, Lawrence H. Young, Harlan M. Krumholz, Marc A. Suchard, Rohan Khera
Publikováno v:
npj Digital Medicine, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract Randomized clinical trials (RCT) represent the cornerstone of evidence-based medicine but are resource-intensive. We propose and evaluate a machine learning (ML) strategy of adaptive predictive enrichment through computational trial phenomap
Externí odkaz:
https://doaj.org/article/e5b6bceab7c2410fa2b117628815a86b
Autor:
Liujun Chen, Lisha Li, Donghong Cui, Yiheng Huang, Haibin Tong, Haleh Zabihi, Shuxia Wang, Yadan Qi, Ted Lakowski, Lin Leng, Suixin Liu, Hong Wu, Lawrence H. Young, Richard Bucala, Dake Qi
Publikováno v:
Molecular Metabolism, Vol 79, Iss , Pp 101834- (2024)
Attenuation of adipose hormone sensitive lipase (HSL) may impair lipolysis and exacerbate obesity. We investigate the role of cytokine, macrophage migration inhibitory factor (MIF) in regulating adipose HSL and adipocyte hypertrophy. Extracellular MI
Externí odkaz:
https://doaj.org/article/4f29c4485e6e43b289fce33599c07ce5
Autor:
Yiheng Huang, Donghong Cui, Liujun Chen, Haibin Tong, Hong Wu, Grace K. Muller, Yadan Qi, Shuxia Wang, Jinjie Xu, Xiang Gao, Kathleen E. Fifield, Lingyan Wang, Zhengyuan Xia, Jacqueline L. Vanderluit, Suixin Liu, Lin Leng, Guang Sun, John McGuire, Lawrence H. Young, Richard Bucala, Dake Qi
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106923- (2023)
Summary: While insulin resistance (IR) is associated with inflammation in white adipose tissue, we report a non-inflammatory adipose mechanism of high fat-induced IR mediated by loss of Pref-1. Pref-1, released from adipose Pref-1+ cells with charact
Externí odkaz:
https://doaj.org/article/4fad11db6db3452e8ef0f35ff8313cab
Publikováno v:
JACC: Case Reports, Vol 3, Iss 2, Pp 314-318 (2021)
Two middle-aged women had evidence suggesting right ventricular hypertrophy on routine electrocardiograms. Their echocardiograms showed right ventricular thickening and cardiac magnetic resonance imaging revealed right ventricular fatty infiltration.
Externí odkaz:
https://doaj.org/article/6948878c495b49bdae80eb8bee26f009
Autor:
Kevin N. Su, Yina Ma, Marine Cacheux, Zeki Ilkan, Nour Raad, Grace K. Muller, Xiaohong Wu, Nicole Guerrera, Stephanie L. Thorn, Albert J. Sinusas, Marc Foretz, Benoit Viollet, Joseph G. Akar, Fadi G. Akar, Lawrence H. Young
Publikováno v:
JCI Insight, Vol 7, Iss 8 (2022)
Metabolic stress is an important cause of pathological atrial remodeling and atrial fibrillation. AMPK is a ubiquitous master metabolic regulator, yet its biological function in the atria is poorly understood in both health and disease. We investigat
Externí odkaz:
https://doaj.org/article/89a8b570681a43d5b439e41dbe042fb5
Autor:
Agnes S. Kim, Katharine J. Henderson, Sumeet Pawar, Min Jung Kim, Shahnaz Punjani, Jeffrey S. Pollak, John T. Fahey, Guadalupe Garcia‐Tsao, Lissa Sugeng, Lawrence H. Young
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 20 (2020)
Background Patients with hereditary hemorrhagic telangiectasia have liver vascular malformations that can cause high‐output cardiac failure (HOCF). Known sequelae include pulmonary hypertension, tricuspid regurgitation, and atrial fibrillation. Met
Externí odkaz:
https://doaj.org/article/9e117051f89748ec8e33003bb18d3982
Autor:
Muhammad Riaz, Jinkyu Park, Lorenzo R. Sewanan, Yongming Ren, Jonas Schwan, Subhash K. Das, Pawel T. Pomianowski, Yan Huang, Matthew W. Ellis, Jiesi Luo, Juli Liu, Loujin Song, I-Ping Chen, Caihong Qiu, Masayuki Yazawa, George Tellides, John Hwa, Lawrence H. Young, Lei Yang, Charles C. Marboe, Daniel L. Jacoby, Stuart G. Campbell, Yibing Qyang
Publikováno v:
Circulation
Background: Familial hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disease and is typically caused by mutations in genes encoding sarcomeric proteins that regulate cardiac contractility. HCM manifestations include left ventri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a76ff451fbfe323dbdddc40644fe8b7
https://doi.org/10.1161/circulationaha.121.056265
https://doi.org/10.1161/circulationaha.121.056265
Autor:
J. David Spence, Catherine Viscoli, Walter N. Kernan, Lawrence H. Young, Karen Furie, Ralph DeFronzo, Muhammad Abdul‐Ghani, Paresh Dandona, Silvio E. Inzucchi
Publikováno v:
Diabetes, Obesity and Metabolism. 24:1150-1158
Pioglitazone is a potent insulin-sensitizing drug with anti-atherosclerotic properties, but adverse effects have limited its use. We assessed the benefits and risks of lower versus higher doses of pioglitazone taken by participants in the Insulin Res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73bc304ad78acbe70eb6fc2bb05f7c24
https://doi.org/10.1111/dom.14687
https://doi.org/10.1111/dom.14687
Autor:
Roxana Ola, Alexandre Dubrac, Jinah Han, Feng Zhang, Jennifer S. Fang, Bruno Larrivée, Monica Lee, Ana A. Urarte, Jan R. Kraehling, Gael Genet, Karen K. Hirschi, William C. Sessa, Francesc V. Canals, Mariona Graupera, Minhong Yan, Lawrence H. Young, Paul S. Oh, Anne Eichmann
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Arteriovenous malformations (AVM) is a hallmark of hereditary haemorrhagic telangiectasia type 2, a disease caused by mutations in BMP receptor ALK1. Ola et al. show that AVM can be caused by blocking BMP9 and BMP10 in mice, leading to increased VEGF
Externí odkaz:
https://doaj.org/article/7b411bab54424730b576b6b6c001bd4f