Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Lawrence G, Hamann"'
Autor:
Steven A. Saenz, Andrea Local, Tiffany Carr, Arvind Shakya, Shivsmriti Koul, Haiqing Hu, Lisa Chourb, Justin Stedman, Jenna Malley, Laura Akullian D’Agostino, Veerabahu Shanmugasundaram, John Malona, C. Eric Schwartz, Lisa Beebe, Meghan Clements, Ganesh Rajaraman, John Cho, Lan Jiang, Alex Dubrovskiy, Matt Kreilein, Roman Shimanovich, Lawrence G. Hamann, Laure Escoubet, J. Michael Ellis
Publikováno v:
PLoS ONE, Vol 16, Iss 11 (2021)
Retinoic acid receptor-related orphan nuclear receptor (ROR) γt is a member of the RORC nuclear hormone receptor family of transcription factors. RORγt functions as a critical regulator of thymopoiesis and immune responses. RORγt is expressed in m
Externí odkaz:
https://doaj.org/article/c77d178e9fdf4a27bb6fc2263243c22d
Autor:
Georg E. Winter, Klemens Hoegenauer, Karl Heinz Krawinkler, Tobias Ritter, Vicky Steadman, Wolfgang Jahnke, Lawrence G. Hamann, Alessio Ciulli, Scott D. Williams, Amit S. Kalgutkar, Thomas Magauer, Antonia F. Stepan
Publikováno v:
ChemMedChem. 16:2417-2423
The second biannual Alpine Winter Conference on Medicinal and Synthetic Chemistry (short: Alpine Winter Conference) took place January 19-23, 2020, in St. Anton in western Austria. There were roughly 180 attendees from around the globe, making this m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e478fc57346eb3701565d11a2aef0c1
https://doi.org/10.1002/cmdc.202100372
https://doi.org/10.1002/cmdc.202100372
Autor:
Youngah Shin, Moo Je Sung, Monish Jain, Jake Axford, Natalie Dales, Ina Dix, Brian Hurley, Lawrence G. Hamann, Karin Briner, Atwood K. Cheung, John I. Manchester, Donovan N. Chin, Rajeev Sivasankaran
Publikováno v:
Journal of Medicinal Chemistry. 64:4744-4761
Spinal muscular atrophy (SMA) is a debilitating neuromuscular disease caused by low levels of functional survival motor neuron protein (SMN) resulting from a deletion or loss of function mutation of the survival motor neuron 1 (SMN1) gene. Branaplam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cb500bf78e4fb0857bfdd9a64443fed
https://doi.org/10.1021/acs.jmedchem.0c02173
https://doi.org/10.1021/acs.jmedchem.0c02173
Autor:
Mary E Matyskiela, Thomas Clayton, Philip P Chamberlain, Aaron Carpenter, Mark Rolfe, Barbra Pagarigan, Joseph J. McDonald, Gang Lu, Eileen Tran, Christopher Mayne, Lawrence G Hamann, Xinde Zheng
Publikováno v:
Nature Structural & Molecular Biology. 27:319-322
Thalidomide-dependent degradation of the embryonic transcription factor SALL4 by the CRL4CRBN E3 ubiquitin ligase is a plausible major driver of thalidomide teratogenicity. The structure of the second zinc finger of SALL4 in complex with pomalidomide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7210984ec5e6072f87bb4c0493f947fc
https://doi.org/10.1038/s41594-020-0405-9
https://doi.org/10.1038/s41594-020-0405-9
Autor:
Courtney G. Havens, Correa Matthew D, Rama K. Narla, Frans Baculi, Kercher Timothy S, Thomas O. Daniel, Roy L. Harris, Brian E. Cathers, Matt Alexander, Mehran F. Moghaddam, Grant Virginia Heather Sharron, Veronique Plantevin, James Carmichael, Katalin Ebinger, Antonia Lopez-Girona, Gody Khambatta, Derek Mendy, Lawrence G Hamann, Joshua Hansen, Katerina Leftheris, Brandon Wade Whitefield, Joseph Piccotti, Nagy Mark A, Rupert Vessey, Yang Tang, Laurie LeBrun, Jim Leisten, Dehua Huang
Publikováno v:
Journal of Medicinal Chemistry. 63:6648-6676
Many patients with multiple myeloma (MM) initially respond to treatment with modern combination regimens including immunomodulatory agents (lenalidomide and pomalidomide) and proteasome inhibitors. However, some patients lack an initial response to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b7c02cb54b83623d7f5d29645738bcd
https://doi.org/10.1021/acs.jmedchem.9b01928
https://doi.org/10.1021/acs.jmedchem.9b01928
Autor:
Jean B. Regard, Tyler J. Harrison, Jake Axford, Laura Axford, Lac Lee, Xianglin Ren, Lin Deng, Aimee Reynolds, Justin Mao, Qian Liu, Anup Patnaik, Evan Cohick, Micah Hollis-Symynkywicz, Sally Loi, Simone Riek, David Dunstan, MooJe Sung, Nathaniel F. Ware, Lawrence G. Hamann, Jovita Marcinkeviciene, Andrew W. Patterson, Martin L. Marro
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1104177874617840d976f7da34edc3f
https://doi.org/10.2139/ssrn.4198908
https://doi.org/10.2139/ssrn.4198908
Autor:
Jean B. Regard, Tyler J. Harrison, Jake Axford, Laura Axford, Lac Lee, Xianglin Ren, Lin Deng, Aimee Reynolds, Justin Mao, Qian Liu, Anup Patnaik, Evan Cohick, Micah Hollis-Symynkywicz, Sally Loi, Simone Riek, Una McKeever, David Dunstan, MooJe Sung, Nathaniel F. Ware, Alan P. Brown, Lawrence G. Hamann, Jovita Marcinkeviciene, Andrew W. Patterson, Martin L. Marro
Publikováno v:
Biochemical Pharmacology. 209:115418
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ca359f22e4e005b5d162fd46603ee41
https://doi.org/10.1016/j.bcp.2023.115418
https://doi.org/10.1016/j.bcp.2023.115418
Publikováno v:
Nature Chemical Biology. 15:937-944
Targeted protein degradation as a therapeutic modality has seen dramatic progress and massive investment in recent years because of the convergence of two key scientific breakthroughs: optimization of first-generation peptidic proteolysis-targeted ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e3393a81a2f4bcc08fe46e5fdb8e8db
https://doi.org/10.1038/s41589-019-0362-y
https://doi.org/10.1038/s41589-019-0362-y
Publikováno v:
Chemical Science
This work describes an expedient access to sp3-rich nitrogen heterocycles via mild photoredox cleavage of 4-alkyl-1,4-dihydropyridines followed by cyclization of the resultant carbon-centered radicals with tethered imines.
A large proportion of
A large proportion of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdd588e77e0364242bfd11f27f893a1a
https://doi.org/10.1039/c9sc03429c
https://doi.org/10.1039/c9sc03429c
Autor:
Jake, Axford, Moo Je, Sung, John, Manchester, Donovan, Chin, Monish, Jain, Youngah, Shin, Ina, Dix, Lawrence G, Hamann, Atwood K, Cheung, Rajeev, Sivasankaran, Karin, Briner, Natalie A, Dales, Brian, Hurley
Publikováno v:
Journal of medicinal chemistry. 64(8)
Spinal muscular atrophy (SMA) is a debilitating neuromuscular disease caused by low levels of functional survival motor neuron protein (SMN) resulting from a deletion or loss of function mutation of the survival motor neuron 1 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::13330dc0c7e19f69d4bd3cf1bf193353
https://pubmed.ncbi.nlm.nih.gov/33822618
https://pubmed.ncbi.nlm.nih.gov/33822618