Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Lawrence Fleckenstein"'
Autor:
Michael Ramharter, Abdoulaye A. Djimde, Isabelle Borghini-Fuhrer, Robert Miller, Jangsik Shin, Adam Aspinall, Naomi Richardson, Martina Wibberg, Lawrence Fleckenstein, Sarah Arbe-Barnes, Stephan Duparc
Publikováno v:
Malaria Journal, Vol 23, Iss 1, Pp 1-18 (2024)
Abstract Background Children are particularly at risk of malaria. This analysis consolidates the clinical data for pyronaridine–artesunate (PA) paediatric granules in children from three randomized clinical trials and a real-world study (CANTAM). M
Externí odkaz:
https://doaj.org/article/c0a0c67d6b674912b88c1f867080b596
Autor:
Beesan Tan, Nicholas Opoku, Simon K Attah, Kwablah Awadzi, Annette C Kuesel, Janis Lazdins-Helds, Craig Rayner, Victoria Ryg-Cornejo, Mark Sullivan, Lawrence Fleckenstein
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 3, p e0010005 (2022)
BackgroundOnchocerciasis ("river blindness"), is a neglected tropical disease caused by the filarial nematode Onchocerca volvulus and transmitted to humans through repeated bites by infective blackflies of the genus Simulium. Moxidectin was approved
Externí odkaz:
https://doaj.org/article/26bf5cd03fd345daab3b326c25adf382
Autor:
Yi Poravuth, Duong Socheat, Ronnatrai Rueangweerayut, Chirapong Uthaisin, Aung Pyae Phyo, Neena Valecha, B H Krishnamoorthy Rao, Emiliana Tjitra, Asep Purnama, Isabelle Borghini-Fuhrer, Stephan Duparc, Chang-Sik Shin, Lawrence Fleckenstein
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e14501 (2011)
New antimalarials are needed for P. vivax and P. falciparum malaria. This study compared the efficacy and safety of pyronaridine-artesunate with that of chloroquine for the treatment of uncomplicated P. vivax malaria.This phase III randomized, double
Externí odkaz:
https://doaj.org/article/7330ac29fab5473284fb972beb6f0618
Publikováno v:
Journal of clinical pharmacologyReferences. 62(10)
Autor:
Michael Ramharter, Stephan Duparc, Abdoulaye Djimde, Mamadou Tekete, Jangsik Shin, Amal Ayyoub, Lawrence Fleckenstein, Janthima Methaneethorn, Isabelle Borghini-Fuhrer
Publikováno v:
Antimicrobial Agents and Chemotherapy
Pyramax is a pyronaridine (PYR)-artesunate (PA) combination for the treatment of uncomplicated malaria in adult and pediatric patients. A granule formulation of this combination is being developed for treatment of uncomplicated P. falciparum and P. v
Autor:
Luis Lopez-Lazaro, Stephan Duparc, Jangsik Shin, Rolf Pokorny, Robert M Miller, Lawrence Fleckenstein, Isabelle Borghini-Fuhrer, Carrie A. Morris, Sarah Arbe-Barnes
Publikováno v:
Antimicrobial Agents and Chemotherapy
The objectives of this study were to characterize any drug-drug interaction between the antimalarial Pyramax (pyronaridine-artesunate [PA]) and the CYP2D6 probe substrate metoprolol and to assess the safety of 60-day or 90-day PA redosing, particular
Autor:
Peter N. Lohstroh, Donald Jung, Luis Lopez-Lazaro, Stephen R. Dueker, Lawrence Fleckenstein, Xin-Ping Fang, Mark Baker, Jangsik Shin, Carrie A. Morris, Li-Quan Wang, Rolf Pokorny, Stephan Duparc, Isabelle Borghini-Fuhrer
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 40:75-86
This was a single dose mass balance and metabolite characterization study of the antimalarial agent pyronaridine. Six healthy male adults were administered a single oral dose of 720 mg pyronaridine tetraphosphate with 800 nCi of radiolabeled (14)C-py
Autor:
Carrie A. Morris, Beesan Tan, Isabelle Borghini-Fuhrer, Lawrence Fleckenstein, Stephan Duparc, Chang-Sik Shin, Donald Jung
Publikováno v:
Antimicrobial Agents and Chemotherapy. 57:5889-5900
Despite the important role of the antimalarial artesunate and its active metabolite dihydroartemisinin (DHA) in malaria treatment efforts, there are limited data on the pharmacokinetics of these agents in pediatric patients. This study evaluated the
Autor:
Howard Abrams, Elizabeth Leung, Isaac I. Bogoch, Kamran Khan, Caroline Nott, Lawrence Fleckenstein, Jay S. Keystone
Publikováno v:
The American Journal of Tropical Medicine and Hygiene. 93:94-96
Two cases of Strongyloides hyperinfection are presented. Ivermectin was initially administered orally and per rectum pending the availability of subcutaneous (SC) preparations. In neither case did rectal suppositories of ivermectin achieve clinically
Autor:
Joan M. Korth-Bradley, Philip R. Mayer, Virginia Parks, Alain Patat, Lawrence Fleckenstein, Kyle Matschke
Publikováno v:
Clinical pharmacology in drug development. 1(1)
The antiparasitic agent moxidectin is under development for the treatment of onchocerciasis. As the first-in-human study of moxidectin used a liquid formulation but other trials used tablets, a study was performed to determine the relative bioavailab