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pro vyhledávání: '"Lawrence Edward Patterson"'
Autor:
Eugene F. Kogut, Neil J. Kallman, Dana L. T. Laird, Marvin M. Hansen, J. Craig Ruble, Chin Liu, Lawrence Edward Patterson, Matthew H. Yates, Ryan J. Linder
Publikováno v:
Organic Process Research & Development. 18:501-510
The synthesis of a MET kinase inhibitor in an overall yield of 22% was achieved over eight steps starting with 3-hydroxybenzaldehyde, an improvement from the initial 12-step process with a 5.4% yield. Highlights of the process chemistry design and de