Zobrazeno 1 - 10
of 174
pro vyhledávání: '"Lawrence E. Samelson"'
Autor:
Cristiane J. Nunes-Santos, HyeSun Kuehn, Brigette Boast, SuJin Hwang, Douglas B. Kuhns, Jennifer Stoddard, Julie E. Niemela, Danielle L. Fink, Stefania Pittaluga, Mones Abu-Asab, John S. Davies, Valarie A. Barr, Tomoki Kawai, Ottavia M. Delmonte, Marita Bosticardo, Mary Garofalo, Magda Carneiro-Sampaio, Raz Somech, Mohammad Gharagozlou, Nima Parvaneh, Lawrence E. Samelson, Thomas A. Fleisher, Anne Puel, Luigi D. Notarangelo, Bertrand Boisson, Jean-Laurent Casanova, Beata Derfalvi, Sergio D. Rosenzweig
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract We describe the first cases of germline biallelic null mutations in ARPC5, part of the Arp2/3 actin nucleator complex, in two unrelated patients presenting with recurrent and severe infections, early-onset autoimmunity, inflammation, and dys
Externí odkaz:
https://doaj.org/article/70df5eaacfeb4302a635c2f9e2561b5d
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Engagement of T cell receptors (TCRs) induces the formation of microclusters that mediate the downstream signalling events. Here the authors show, using high resolution TIRF-SIM and live cell imaging, that ZAP70 and LAT are recruited to TCR with dist
Externí odkaz:
https://doaj.org/article/886499537f5d4d8a84ce8c1d223bc7f0
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2021)
When T cell receptors (TCRs) engage with stimulatory ligands, one of the first microscopically visible events is the formation of microclusters at the site of T cell activation. Since the discovery of these structures almost 20 years ago, they have b
Externí odkaz:
https://doaj.org/article/53cd639afaa14b64aba7e7091be49cf1
Autor:
Lakshmi Balagopalan, Jason Yi, Tiffany Nguyen, Katherine M. McIntire, Adam S. Harned, Kedar Narayan, Lawrence E. Samelson
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Controversy exists over the function of plasma membrane versus intracellular vesicular LAT in T-cell receptor signaling. Here the authors use high resolution imaging of the temporal dynamics of LAT involvement to show that both sources of LAT are req
Externí odkaz:
https://doaj.org/article/1b98fb09066a499aa682b8e55ae6a06f
Autor:
Ana Dios-Esponera, Nicolas Melis, Bhagawat C. Subramanian, Roberto Weigert, Lawrence E. Samelson
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Normal function of the adaptive immune system requires trafficking of T cells between the blood and lymphoid organs. Lymphocyte homing to lymph nodes requires that they cross endothelial barriers present in blood vessels and lymphatics. This multi-st
Externí odkaz:
https://doaj.org/article/8153e5895b47424b8d23e08bf4895a2d
Autor:
Eilon Sherman, Valarie A. Barr, Robert K. Merrill, Carole K. Regan, Connie L. Sommers, Lawrence E. Samelson
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Imaging the nanostructure of signalling complexes in cells is challenging. Here, the authors present a multicolour, single-molecule, super-resolution approach with statistical tools to reveal a hierarchical topology and synergy of signalling complexe
Externí odkaz:
https://doaj.org/article/13ef84514ec6495aa1fd7ae991fc680e
Autor:
Lakshmi Balagopalan, Taylor Moreno, Haiying Qin, Jason Yi, Katherine M. McIntire, Neriah Alvinez, Sandeep Pallikkuth, Mariah E. Lee, Hidehiro Yamane, Andy D. Tran, Philippe Youkharibache, Raul E. Cachau, Naomi Taylor, Lawrence E. Samelson
Chimeric antigen receptors (CAR) T cells have been successfully used to treat lymphoma, leukemia, and multiple myeloma, but adverse effects due to cytokine secretion, CAR-T cell exhaustion, and loss of target antigen have limited their potential. Fur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e705211840fd39541b02499b098ac3cc
https://doi.org/10.1101/2022.12.25.521452
https://doi.org/10.1101/2022.12.25.521452
Autor:
Lawrence E. Samelson, Grace Bugos, Lijin Dong, Sunmee Huh, Connie L. Sommers, Xing Li, Chuan-Jin Wu, Wenmei Li, Kiyoto Kurima, Andrew J. Griffith
Publikováno v:
J Biol Chem
The TMC genes encode a set of homologous transmembrane proteins whose functions are not well understood. Biallelic mutations in either TMC6 or TMC8 are detected in more than half of cases of the pre-malignant skin disease epidermodysplasia verrucifor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::225db6a6ff3c37fd722103681a3887d3
https://doi.org/10.1074/jbc.ra120.013045
https://doi.org/10.1074/jbc.ra120.013045
Autor:
Junya Wada, Udumbara Rathnayake, Lisa M. Jenkins, Avinash Singh, Moosa Mohammadi, Ettore Appella, Paul A. Randazzo, Lawrence E. Samelson
Publikováno v:
The Journal of biological chemistry. 298(3)
Activation of T cells upon engagement of the T cell antigen receptor rapidly leads to a number of phosphorylation and plasma membrane recruitment events. For example, translocation of phospholipase-Cγ1 (PLC-γ1) to the plasma membrane and its associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4904d816d0960e123efdccad791154a
https://pubmed.ncbi.nlm.nih.gov/35124007
https://pubmed.ncbi.nlm.nih.gov/35124007
Autor:
Alexandre K Rouquette-Jazdanian, Robert L Kortum, Wenmei Li, Robert K Merrill, Phan H Nguyen, Lawrence E Samelson, Connie L Sommers
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0131823 (2015)
Linker for Activation of T cells (LAT) is an adapter protein that is essential for T cell function. Knock-in mice with a LAT mutation impairing calcium flux develop a fatal CD4+ lymphoproliferative disease. miR-155 is a microRNA that is correlated wi
Externí odkaz:
https://doaj.org/article/03cf505e37834812bd4cc6d93e2df137