Výsledky vyhledávání - "Lawrence E. Goldfinger"

Akademický článek

High-efficiency unassisted transfection of platelets with naked double-stranded miRNAs modulates signal-activated translation and platelet function

Autor: Sophia Lazar, Jeremy G.T. Wurtzel, Xi Chen, Peisong Ma, Lawrence E. Goldfinger

Publikováno v: Platelets, Vol 32, Iss 6, Pp 794-806 (2021)

We sought novel approaches to improve transfection efficiencies of microRNAs (miRNAs) in platelets, and to apply these approaches to investigate the roles of miRNAs in regulating signal-activated protein translation and functional effects. We found t

Externí odkaz: https://doaj.org/article/4408707ad7d645a5973035dda75ec697

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Akademický článek

GRK6 regulates the hemostatic response to injury through its rate-limiting effects on GPCR signaling in platelets

Autor: Xi Chen, Shuchi Gupta, Matthew Cooper, Daniel DeHelian, Xuefei Zhao, Meghna U. Naik, Jeremy G.T. Wurtzel, Timothy J. Stalker, Lawrence E. Goldfinger, Jeffrey Benovic, Lawrence F. Brass, Steven E. McKenzie, Ulhas P. Naik, Peisong Ma

Publikováno v: Blood Advances, Vol 4, Iss 1, Pp 76-86 (2020)

Abstract: G protein–coupled receptors (GPCRs) mediate the majority of platelet activation in response to agonists. However, questions remain regarding the mechanisms that provide negative feedback toward activated GPCRs to limit platelet activation

Externí odkaz: https://doaj.org/article/9286a5cfa8b840369f56985b7b2a876e

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Akademický článek

Defective RAB1B-related megakaryocytic ER-to-Golgi transport in RUNX1 haplodeficiency: impact on von Willebrand factor

Autor: Gauthami Jalagadugula, Lawrence E. Goldfinger, Guangfen Mao, Michele P. Lambert, A. Koneti Rao

Publikováno v: Blood Advances, Vol 2, Iss 7, Pp 797-806 (2018)

Abstract: Patients with RUNX1 haplodeficiency have thrombocytopenia, platelet dysfunction, and deficiencies of α-granules and dense granules. Platelet expression profiling of a patient with a heterozygous RUNX1 mutation (c.969-323G>T) revealed decre

Externí odkaz: https://doaj.org/article/0d97a35f27784031a8aa180f04379b2d

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Akademický článek

Platelet Microparticles and miRNA Transfer in Cancer Progression: Many Targets, Modes of Action, and Effects Across Cancer Stages

Autor: Sophia Lazar, Lawrence E. Goldfinger

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 5 (2018)

Platelet-derived microparticles (PMPs) have long been known to increase in circulation in the presence of cancer, and have been considered to be cancer promoting by multiple mechanisms including shrouding of circulating tumor cells allowing immune ev

Externí odkaz: https://doaj.org/article/c14b58573a13447ea2ae5ae98cd3e431

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