Výsledky vyhledávání - "Lawrence E Samelson"

Akademický článek

Bypassing ubiquitination enables LAT recycling to the cell surface and enhanced signaling in T cells.

Autor: Lakshmi Balagopalan, Hiba Malik, Katherine M McIntire, Joseph A Garvey, Tiffany Nguyen, Ana B Rodriguez-Peña, Lawrence E Samelson

Publikováno v: PLoS ONE, Vol 15, Iss 2, p e0229036 (2020)

LAT molecules defective in ubiquitination have an increased half-life and induce enhanced signaling when expressed in T cells. In this study, we have examined the role of ubiquitination in regulating LAT endocytosis, recycling, and degradation in res

Externí odkaz: https://doaj.org/article/051f987b358c455d90bd9b2384a1a8bc

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Akademický článek

miR-155 Controls Lymphoproliferation in LAT Mutant Mice by Restraining T-Cell Apoptosis via SHIP-1/mTOR and PAK1/FOXO3/BIM Pathways.

Autor: Alexandre K Rouquette-Jazdanian, Robert L Kortum, Wenmei Li, Robert K Merrill, Phan H Nguyen, Lawrence E Samelson, Connie L Sommers

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0131823 (2015)

Linker for Activation of T cells (LAT) is an adapter protein that is essential for T cell function. Knock-in mice with a LAT mutation impairing calcium flux develop a fatal CD4+ lymphoproliferative disease. miR-155 is a microRNA that is correlated wi

Externí odkaz: https://doaj.org/article/03cf505e37834812bd4cc6d93e2df137

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Akademický článek

miRNA signature of mouse helper T cell hyper-proliferation.

Autor: Connie L Sommers, Alexandre K Rouquette-Jazdanian, Ana I Robles, Robert L Kortum, Robert K Merrill, Wenmei Li, Nandan Nath, Elizabeth Wohlfert, Katherine M Sixt, Yasmine Belkaid, Lawrence E Samelson

Publikováno v: PLoS ONE, Vol 8, Iss 6, p e66709 (2013)

Helper T cells from a mutant mouse model, LAT Y136F, hyper-proliferate and cause a severe lymphoproliferative disease that kills the mice by six months of age. LAT Y136F mice carry a tyrosine to phenylalanine mutation in the Linker for Activation of

Externí odkaz: https://doaj.org/article/b7f3e2322d024f03b46f3a24eadde5b5

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Akademický článek

Inherited ARPC5 mutations cause an actinopathy impairing cell motility and disrupting cytokine signaling

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)

Abstract We describe the first cases of germline biallelic null mutations in ARPC5, part of the Arp2/3 actin nucleator complex, in two unrelated patients presenting with recurrent and severe infections, early-onset autoimmunity, inflammation, and dys

Externí odkaz: https://doaj.org/article/70df5eaacfeb4302a635c2f9e2561b5d

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Generation of anti-tumor chimeric antigen receptors incorporating T cell signaling motifs

Autor: Lakshmi Balagopalan, Taylor Moreno, Haiying Qin, Jason Yi, Katherine M. McIntire, Neriah Alvinez, Sandeep Pallikkuth, Mariah E. Lee, Hidehiro Yamane, Andy D. Tran, Philippe Youkharibache, Raul E. Cachau, Naomi Taylor, Lawrence E. Samelson

Chimeric antigen receptors (CAR) T cells have been successfully used to treat lymphoma, leukemia, and multiple myeloma, but adverse effects due to cytokine secretion, CAR-T cell exhaustion, and loss of target antigen have limited their potential. Fur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e705211840fd39541b02499b098ac3cc
https://doi.org/10.1101/2022.12.25.521452

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Expression of a TMC6-TMC8-CIB1 heterotrimeric complex in lymphocytes is regulated by each of the components

Autor: Lawrence E. Samelson, Grace Bugos, Lijin Dong, Sunmee Huh, Connie L. Sommers, Xing Li, Chuan-Jin Wu, Wenmei Li, Kiyoto Kurima, Andrew J. Griffith

Publikováno v: J Biol Chem

The TMC genes encode a set of homologous transmembrane proteins whose functions are not well understood. Biallelic mutations in either TMC6 or TMC8 are detected in more than half of cases of the pre-malignant skin disease epidermodysplasia verrucifor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::225db6a6ff3c37fd722103681a3887d3
https://doi.org/10.1074/jbc.ra120.013045

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In vitro reconstitution reveals cooperative mechanisms of adapter protein-mediated activation of phospholipase C-γ1 in T cells

Autor: Junya Wada, Udumbara Rathnayake, Lisa M. Jenkins, Avinash Singh, Moosa Mohammadi, Ettore Appella, Paul A. Randazzo, Lawrence E. Samelson

Publikováno v: The Journal of biological chemistry. 298(3)

Activation of T cells upon engagement of the T cell antigen receptor rapidly leads to a number of phosphorylation and plasma membrane recruitment events. For example, translocation of phospholipase-Cγ1 (PLC-γ1) to the plasma membrane and its associ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4904d816d0960e123efdccad791154a
https://pubmed.ncbi.nlm.nih.gov/35124007

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Microclusters as T Cell Signaling Hubs: Structure, Kinetics, and Regulation

Autor: Kumarkrishna Raychaudhuri, Lawrence E. Samelson, Lakshmi Balagopalan

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 8 (2021)
Frontiers in Cell and Developmental Biology

When T cell receptors (TCRs) engage with stimulatory ligands, one of the first microscopically visible events is the formation of microclusters at the site of T cell activation. Since the discovery of these structures almost 20 years ago, they have b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6f707cbd1d1bbcfbd2189168edf3ad1
https://www.frontiersin.org/articles/10.3389/fcell.2020.608530/full

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