Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Lawrence D. Harris"'
Autor:
Andreas Luxenburger, Lawrence D. Harris, Elizabeth M. Ure, Roselis A. Landaeta Aponte, Anthony D. Woolhouse, Scott A. Cameron, Chris D. Ling, Ross O. Piltz, Andrew R. Lewis, Graeme J. Gainsford, Alex Weymouth-Wilson, Richard H. Furneaux
Publikováno v:
ACS Omega, Vol 6, Iss 38, Pp 25019-25039 (2021)
Externí odkaz:
https://doaj.org/article/a96697489bbf4f2986e68657380fa0b6
Autor:
Jo-Ann L. Stanton, Rory O'Brien, Richard J. Hall, Anastasia Chernyavtseva, Hye Jeong Ha, Lauren Jelley, Peter D. Mace, Alexander Klenov, Jackson M. Treece, John D. Fraser, Fiona Clow, Lewis Clarke, Yongdong Su, Harikrishnan M. Kurup, Vyacheslav V. Filichev, William Rolleston, Lee Law, Phillip M. Rendle, Lawrence D. Harris, James M. Wood, Thomas W. Scully, James E. Ussher, Jenny Grant, Timothy A. Hore, Tim V. Moser, Rhodri Harfoot, Blair Lawley, Miguel E. Quiñones-Mateu, Patrick Collins, Richard Blaikie
Publikováno v:
Frontiers in Public Health, Vol 9 (2022)
The rapid global rise of COVID-19 from late 2019 caught major manufacturers of RT-qPCR reagents by surprise and threw into sharp focus the heavy reliance of molecular diagnostic providers on a handful of reagent suppliers. In addition, lockdown and t
Externí odkaz:
https://doaj.org/article/c88caa11fedb42cf8990b491e7b3d6af
Autor:
Andreas Luxenburger, Hannah Clemmens, Christopher Hastings, Lawrence D. Harris, Elizabeth M. Ure, Scott A. Cameron, Jan Aasly, Oliver Bandmann, Alex Weymouth-Wilson, Richard H. Furneaux, Heather Mortiboys
Publikováno v:
Biomolecules, Vol 13, Iss 1, p 76 (2022)
Parkinson’s Disease is the most common neurodegenerative movement disorder globally, with prevalence increasing. There is an urgent need for new therapeutics which are disease-modifying rather than symptomatic. Mitochondrial dysfunction is a well-d
Externí odkaz:
https://doaj.org/article/10fa3e7741d34b5aa0f3a0fb5b533fbd
Autor:
Roselis A. Landaeta Aponte, Andreas Luxenburger, Scott A. Cameron, Alex Weymouth-Wilson, Richard H. Furneaux, Lawrence D. Harris, Benjamin J. Compton
Publikováno v:
Molecules, Vol 27, Iss 7, p 2364 (2022)
Bile acid receptors have been identified as important targets for the development of new therapeutics to treat various metabolic and inflammatory diseases. The synthesis of new bile acid analogues can help elucidate structure–activity relationships
Externí odkaz:
https://doaj.org/article/2c1d56711d7d4f37b12a93a98705d3c3
Autor:
Kevin J. Sparrow, Rinu Shrestha, James M. Wood, Keith Clinch, Brett L. Hurst, Hong Wang, Brian B. Gowen, Justin G. Julander, E. Bart Tarbet, Alice M. McSweeney, Vernon K. Ward, Gary B. Evans, Lawrence. D. Harris
Publikováno v:
ACS Medicinal Chemistry Letters. 14:506-513
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4d43179c43e8630cced245bf2621c5f
https://doi.org/10.1021/acsmedchemlett.3c00048
https://doi.org/10.1021/acsmedchemlett.3c00048
Autor:
Samuele Sala, Philipp Nitschke, Reika Masuda, Nicola Gray, Nathan Lawler, James M. Wood, Georgy Berezhnoy, Alejandro Bolaños, Berin A. Boughton, Caterina Lonati, Titus Rössler, Yogesh Singh, Ian D. Wilson, Samantha Lodge, Aude-Claire Morillon, Ruey Leng Loo, Drew Hall, Luke Whiley, Gary B. Evans, Tyler L. Grove, Steven C. Almo, Lawrence D. Harris, Elaine Holmes, Uta Merle, Christoph Trautwein, Jeremy K. Nicholson, Julien Wist
We present compelling evidence for the existence of an evolutionary adaptive response to viral agents such as SARS-CoV-2, that results in the humanin vivobiosynthesis of a family of compounds with potential antiviral activity. Using nuclear magnetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28ddce5fd876c958f18b755968cee278
https://doi.org/10.1101/2023.05.08.23289637
https://doi.org/10.1101/2023.05.08.23289637
Autor:
Elizabeth M. Ure, Lawrence D. Harris, Scott A. Cameron, Alex Weymouth-Wilson, Richard H. Furneaux, Janet L. Pitman, Simon. F. Hinkley, Andreas Luxenburger
Publikováno v:
Organic & Biomolecular Chemistry. 20:3511-3527
A series of 12β-methyl-18-nor-avicholic acid analogues was prepared and evaluated for activity at TGR5 and FXR. Compounds 46 and 53 emerged as low-micromolar TGR5 agonists, providing potential new templates for further development.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a00634e7e2998e163b7e5b1f9d560be4
https://doi.org/10.1039/d1ob02401a
https://doi.org/10.1039/d1ob02401a
Autor:
Andreas Luxenburger, Nicola Bougen-Zhukov, Michael G. Fraser, Henry Beetham, Lawrence D. Harris, Dorian Schmidt, Scott A. Cameron, Parry J. Guilford, Gary B. Evans
Publikováno v:
Journal of Medicinal Chemistry. 64:18114-18142
Diffuse gastric cancer and lobular breast cancer are aggressive malignancies that are frequently associated with inactivating mutations in the tumor suppressor gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e4f6944cc1b194abfcfa0380f71e398
https://doi.org/10.1021/acs.jmedchem.1c01609
https://doi.org/10.1021/acs.jmedchem.1c01609
Autor:
Mortiboys, Andreas Luxenburger, Hannah Clemmens, Christopher Hastings, Lawrence D. Harris, Elizabeth M. Ure, Scott A. Cameron, Jan Aasly, Oliver Bandmann, Alex Weymouth-Wilson, Richard H. Furneaux, Heather
Publikováno v:
Biomolecules; Volume 13; Issue 1; Pages: 76
Parkinson’s Disease is the most common neurodegenerative movement disorder globally, with prevalence increasing. There is an urgent need for new therapeutics which are disease-modifying rather than symptomatic. Mitochondrial dysfunction is a well-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::0f25bac1f2d8daa0c3bbf0ff9e71570b
Autor:
Sandesh Deshpande, Wenjuan Huo, Rinu Shrestha, Kevin Sparrow, Gary B. Evans, Lawrence D. Harris, Richard L. Kingston, Esther M. M. Bulloch
Millions of people are infected by the Dengue and Zika viruses each year, which can result in serious illness, permanent disability or death. There are currently no FDA-approved antivirals for treating infection by these viruses. Galidesivir is an ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf16530901d210e09e7934585641209b
https://doi.org/10.1101/2022.12.20.521302
https://doi.org/10.1101/2022.12.20.521302