Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Lawrence D. Brewer"'
Autor:
Nada M Porter, Julia H Bohannon, Meredith Curran-Rauhut, Heather M Buechel, Amy L S Dowling, Lawrence D Brewer, Jelena Popovic, Veronique Thibault, Susan D Kraner, Kuey Chu Chen, Eric M Blalock
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40128 (2012)
Many aging changes seem similar to those elicited by sleep-deprivation and psychosocial stress. Further, sleep architecture changes with age suggest an age-related loss of sleep. Here, we hypothesized that sleep deprivation in young subjects would el
Externí odkaz:
https://doaj.org/article/7085ad75f8ce40cfbfb2afe867472fd3
Autor:
Caitlin S Latimer, James L Searcy, Michael T Bridges, Lawrence D Brewer, Jelena Popović, Eric M Blalock, Philip W Landfield, Olivier Thibault, Nada M Porter
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26812 (2011)
Healthy brain aging and cognitive function are promoted by exercise. The benefits of exercise are attributed to several mechanisms, many which highlight its neuroprotective role via actions that enhance neurogenesis, neuronal morphology and/or neurot
Externí odkaz:
https://doaj.org/article/b50ce6239c58484c9293c5b3e7a93b83
Autor:
Philip W. Landfield, Susan D. Kraner, Jessie B. Hoffman, Eric M. Blalock, Nada M. Porter, Katie L. Anderson, Olivier Thibault, Lawrence D. Brewer, Julien Thibault, John C. Gant, Adam Ghower, Hilaree N. Frazier
OBJECTIVES: Increasing evidence suggests that vitamin D plays a role in maintaining cognitive function and that vitamin D deficiency may accelerate age-related cognitive decline. Here, we determined if a long-term enhanced vitamin D (VitD3, cholecalc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09d132019a7f39b9da69652c6444f679
https://europepmc.org/articles/PMC6574112/
https://europepmc.org/articles/PMC6574112/
Autor:
Lawrence D. Brewer, Ai-Ling Lin, Nada M. Porter, Zana R. Majeed, Olivier Thibault, Shaniya Maimaiti, Hilaree N. Frazier, Katie L. Anderson, Vikas Bakshi
Publikováno v:
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 72:189-197
Novel therapies have turned to delivering compounds to the brain using nasal sprays, bypassing the blood brain barrier, and enriching treatment options for brain aging and/or Alzheimer's disease. We conducted a series of in vivo experiments to test t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fd0905138ffd6c7a8478a66f9563298
https://doi.org/10.1093/gerona/glw065
https://doi.org/10.1093/gerona/glw065
Autor:
Lawrence D. Brewer, Olivier Thibault, Katie L. Anderson, Shaniya Maimaiti, Nada M. Porter, Chris DeMoll, John C. Gant, Eric M. Blalock, Benjamin A. Rauh
Publikováno v:
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 71:30-39
Peripheral insulin resistance is a key component of metabolic syndrome associated with obesity, dyslipidemia, hypertension, and type 2 diabetes. While the impact of insulin resistance is well recognized in the periphery, it is also becoming apparent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::312e47151630582f977a9ff9c7ebc3c2
https://doi.org/10.1093/gerona/glu314
https://doi.org/10.1093/gerona/glu314
Autor:
Lawrence D. Brewer, Nada M. Porter, Shaniya Maimaiti, Adam O. Ghoweri, Olivier Thibault, Hilaree N. Frazier, Katie L. Anderson
Publikováno v:
Neuroscience. 364
Both insulin signaling disruption and Ca 2+ dysregulation are closely related to memory loss during aging and increase the vulnerability to Alzheimer’s disease (AD). In hippocampal neurons, aging-related changes in calcium regulatory pathways have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ade5d36867500b2af80453a5db009570
https://pubmed.ncbi.nlm.nih.gov/28939258
https://pubmed.ncbi.nlm.nih.gov/28939258
Autor:
Nada M. Porter, D. Allan Butterfield, Jian Cai, Lawrence D. Brewer, Sarah Förster, Caitlin S. Latimer, Jeriel T. R. Keeney, Rukhsana Sultana, Jon B. Klein
Publikováno v:
Free Radical Biology and Medicine. 65:324-334
In addition to the well-known effects of vitamin D (VitD) in maintaining bone health, there is increasing appreciation that this vitamin may serve important roles in other organs and tissues, including the brain. Given that VitD deficiency is especia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4b51a783285a62691ea8d41d4360dc4
https://doi.org/10.1016/j.freeradbiomed.2013.07.019
https://doi.org/10.1016/j.freeradbiomed.2013.07.019
Autor:
Lawrence D. Brewer, Katie L. Anderson, Olivier Thibault, Philip W. Landfield, Nada M. Porter, Chris DeMoll
Publikováno v:
European Journal of Pharmacology. 719:34-43
Accumulating evidence is associating disorders of lipid and glucose metabolism, including the overlapping conditions of insulin resistance/metabolic syndrome, obesity and diabetes, with moderate cognitive impairment in normal aging and elevated risk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4833b0d06899137df3537964782cea5
https://doi.org/10.1016/j.ejphar.2013.07.024
https://doi.org/10.1016/j.ejphar.2013.07.024
Autor:
Lawrence D. Brewer, Meredith A. Curran-Rauhut, Kuey-Chu Chen, Nada M. Porter, Eric M. Blalock, Inga Kadish, Susan J. Blalock, Philip W. Landfield
Publikováno v:
Endocrinology
Although glucocorticoids (GCs) are known to exert numerous effects in the hippocampus, their chronic regulatory functions remain poorly understood. Moreover, evidence is inconsistent regarding the long-standing hypothesis that chronic GC exposure pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90f74537666ca54c669c4cd81476f4a9
https://doi.org/10.1210/en.2013-1139
https://doi.org/10.1210/en.2013-1139
Autor:
Nada M. Porter, Lawrence D. Brewer, Olivier Thibault, Katie L. Anderson, Hilaree N. Frazier, John C. Gant, Shaniya Maimaiti
Publikováno v:
Biochemical and biophysical research communications. 483(4)
Neuroscientists studying normal brain aging, spinal cord injury, Alzheimer's disease (AD) and other neurodegenerative diseases have focused considerable effort on carefully characterizing intracellular perturbations in calcium dynamics or levels. At
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0d38d27a35ab627860f6dd09ff111e6
https://pubmed.ncbi.nlm.nih.gov/27553276
https://pubmed.ncbi.nlm.nih.gov/27553276