Výsledky vyhledávání - "Lawrence D. Adams"

Regulator of G protein signaling 5 marks peripheral arterial smooth muscle cells and is downregulated in atherosclerotic plaque

Autor: Xi Wang, Randolph L. Geary, Jing Li, Stephen M. Schwartz, Lil Pabon, Lawrence D. Adams, David C. Sane

Publikováno v: Journal of Vascular Surgery. 40(3):519-528

Objective Regulator of G protein signaling 5 (RGS5), an inhibitor of Gα(q) and Gα(i) activation, was recently identified among genes highly expressed in smooth muscle cells (SMCs) of aorta but not vena cava. This finding prompted the hypothesis tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b24b819b80b3853435f3bd7b6a7cc9d1

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Vascular failure: A hypothesis

Autor: Stephen M. Schwartz, Lawrence D. Adams, Randolph L. Geary

Publikováno v: Current Atherosclerosis Reports. 5:201-207

Although cardiac failure has been studied extensively, vascular failure is not a recognizable term. We suggest that it is reasonable to argue that failure of the vessel to control its mass, contractile capacity, and lumen will involve pathways simila

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::323f00dac2425b73ed0f71e85fce5fee
https://doi.org/10.1007/s11883-003-0025-y

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Expression Profiling Identifies 147 Genes Contributing to a Unique Primate Neointimal Smooth Muscle Cell Phenotype

Autor: Randolph L. Geary, Lawrence D. Adams, A. J. Rossini, Stephen M. Schwartz, James M. Wong

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 22:2010-2016

Objective— This study represents the first in an effort to systematically characterize different intimas by using expression array analysis. Methods and Results— We compared smooth muscle cells (SMCs) of the neointima formed 4 weeks after aortic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::677a02f24952cd13126390368854b4a1
https://doi.org/10.1161/01.atv.0000038147.93527.35

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Heterophilic NCAM-Mediated Cell Adhesion to Proteoglycans from Chick Embryonic Brain Membranes

Autor: Ben A. Murray, Lawrence D. Adams, V.Madhu Anvekar, Scott D. Storms

Publikováno v: Experimental Cell Research. 223:385-394

The vertebrate neural cell adhesion molecule NCAM mediates adhesion by both homophilic and heterophilic mechanisms, with heparan sulfate proteoglycans (HSPGs) being likely heterophilic ligands. In this study, transfected chicken NCAM polypeptides exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cf40e07812005ea2e973cd750e7b758
https://doi.org/10.1006/excr.1996.0093

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The Large Cytoplasmic Domain Is Not Required for Concentration of N-CAM at Cell-Cell Contacts in Transfected Mouse Neuroblastoma Cells

Autor: Lawrence D. Adams, Mary K. Woo, Ben A. Murray, Sung-Hee Kil, Thanh N. Nguyen

Publikováno v: Experimental Cell Research. 205:331-336

We examined the localization of the 140- and 180-kDa transmembrane isoforms of chicken N-CAM following transfection into mouse N2A neuroblastoma cells. Both isoforms were expressed at the cell surface and became partially or completely localized at a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7476731a65390e44a350f62bbb4b7bf0
https://doi.org/10.1006/excr.1993.1094

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Correction: Capillary Regeneration in Scleroderma: Stem Cell Therapy Reverses Phenotype?

Autor: M. Kari Connolly, Robert Lafyatis, Gretchen Henstorf, Stephen M. Schwartz, Howard M. Shulman, David Fiorentino, Jo Nadine Fleming, D. O. McLeod, Richard A. Nash, Lawrence D. Adams, Jerry A. Molitor, Daniel E. Furst, David K. Pritchard

Publikováno v: PLoS ONE, Vol 3, Iss 8 (2008)
PLoS ONE

There was a sentence omitted from the Funding section. The complete funding information is as follows: This work was funded by the scleroderma Research Foundation that had no role in the design and conduct of the study, in the collection, analysis, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61b4bde17d18d0b3b81a41a4597e0f20
http://europepmc.org/articles/PMC2645286

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RGS5, RGS4, and RGS2 expression and aortic contractibility are dynamically co-regulated during aortic banding-induced hypertrophy

Autor: William M. Mahoney, Lil Pabon, Diane Beaudry, Stephen M. Schwartz, Xi Wang, Denis deBlois, Lawrence D. Adams, Jagadambika J. Gunaje, Randolph L. Geary

Publikováno v: Journal of molecular and cellular cardiology. 44(3)

Overexpression of regulator of G protein signaling 5 (RGS5) in arteries over veins is the most striking difference observed using microarray analysis. The obvious question is what arterial function might require RGS5. Based on functions of homologous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c574eaba8722303dc2554540a746f3
https://pubmed.ncbi.nlm.nih.gov/18207159

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Expression profiling identifies smooth muscle cell diversity within human intima and plaque fibrous cap: loss of RGS5 distinguishes the cap

Autor: Jing Li, A. J. Rossini, Randolph L. Geary, Lawrence D. Adams, Stephen M. Schwartz

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology. 26(2)

Background— The fibrous cap of the atherosclerotic lesion is believed to be critical to stability because disruption of the cap is the final event leading to plaque rupture. We have, therefore, used expression arrays to define the phenotype of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f24036cd98faadd3ed49eddb5db834ef
https://pubmed.ncbi.nlm.nih.gov/16293795

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