Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Lawrence Chen"'
Publikováno v:
Neural Regeneration Research, Vol 18, Iss 4, Pp 763-768 (2023)
Neuroinflammation plays a critical role in the pathological process of multiple neurological disorders and pathological pain conditions. GPR109A, a Gi protein-coupled receptor, has emerged as an important therapeutic target for controlling inflammati
Externí odkaz:
https://doaj.org/article/2a75c9f6433840b98e3a1241440eb1a5
Autor:
Renée Procopio-Melino, Frank W. Kotch, Amar S. Prashad, Jose M. Gomes, Wenge Wang, Bo Arve, Andrew Dawdy, Lawrence Chen, Justin Sperry, Christine Hosselet, Tao He, Ronald Kriz, Laura Lin, Kimberly Marquette, Lioudmila Tchistiakova, Will Somers, Jason C. Rouse, Xiaotian Zhong
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Next-generation site-specific cysteine-based antibody–drug-conjugates (ADCs) broaden therapeutic index by precise drug-antibody attachments. However, manufacturing such ADCs for clinical validation requires complex full reduction and reoxi
Externí odkaz:
https://doaj.org/article/5cda877d16ac4d3e838e8490f8f4c4f8
Publikováno v:
Cells, Vol 12, Iss 7, p 1058 (2023)
Recent studies by us and others have shown that enhancer of zeste homolog-2 (EZH2), a histone methyltransferase, in glial cells regulates the genesis of neuropathic pain by modulating the production of proinflammatory cytokines and chemokines. In thi
Externí odkaz:
https://doaj.org/article/e537250281a44525aff16f220a18f006
Autor:
Jessica E. Rexach, Damon Polioudakis, Anna Yin, Vivek Swarup, Timothy S. Chang, Tam Nguyen, Arjun Sarkar, Lawrence Chen, Jerry Huang, Li-Chun Lin, William Seeley, John Q. Trojanowski, Dheeraj Malhotra, Daniel H. Geschwind
Publikováno v:
Cell Reports, Vol 33, Iss 7, Pp 108398- (2020)
Summary: To understand how neural-immune-associated genes and pathways contribute to neurodegenerative disease pathophysiology, we performed a systematic functional genomic analysis in purified microglia and bulk tissue from mouse and human AD, FTD,
Externí odkaz:
https://doaj.org/article/37aa7e68692a4664bc402acdec6fd6ab
Publikováno v:
International Journal of Molecular Sciences, Vol 15, Iss 7, Pp 11597-11613 (2014)
Zipper-interacting protein kinase (ZIPK) is a conserved vertebrate-specific regulator of actomyosin contractility in smooth muscle and non-muscle cells. Murine ZIPK has undergone an unusual divergence in sequence and regulation compared to other ZIPK
Externí odkaz:
https://doaj.org/article/ed48f821744d4b88973a9003db5ac57f
Autor:
Liu, Shenggui, Li, Chaojiang, Jin, Xin, Jiang, Wang, Cao, Xun, Liu, Guodong, Guo, Zilong, Yang, YuXin, Ong, Lawrence Chen Lym
Publikováno v:
In Additive Manufacturing 5 July 2023 73
Autor:
Pranesh Muralidhar, Antonio Ramirez, Aiwen Wu, Lawrence Chen, Yamin Liu, Luxi Shen, Robert Blacksmith, Sabrina Wong, Matthew Melanson, Andrey Rudenko
Publikováno v:
Advances in Patterning Materials and Processes XL.
Autor:
Lawrence Fong, Adil I. Daud, Mai H. Le, Robert H. Pierce, Alan Paciorek, Li Zhang, Christopher G. Twitty, Lawrence Chen, Kathryn T. Takamura, Katy K. Tsai, Alain P. Algazi, Samantha K. Greaney
Whereas systemic IL12 is associated with potentially life-threatening toxicity, intratumoral delivery of IL12 through tavokinogene telseplasmid electroporation (tavo) is safe and can induce tumor regression at distant sites. The mechanism by which th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28ba2b2721404c2e21aea696350dbd37
https://doi.org/10.1158/2326-6066.c.6550222.v1
https://doi.org/10.1158/2326-6066.c.6550222.v1
Autor:
Lawrence Fong, Adil I. Daud, Mai H. Le, Robert H. Pierce, Alan Paciorek, Li Zhang, Christopher G. Twitty, Lawrence Chen, Kathryn T. Takamura, Katy K. Tsai, Alain P. Algazi, Samantha K. Greaney
Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dd29f92e0542fe150bc20a0a767f4d2
https://doi.org/10.1158/2326-6066.22543339.v1
https://doi.org/10.1158/2326-6066.22543339.v1
Autor:
Lawrence Fong, Adil I. Daud, Mai H. Le, Robert H. Pierce, Alan Paciorek, Li Zhang, Christopher G. Twitty, Lawrence Chen, Kathryn T. Takamura, Katy K. Tsai, Alain P. Algazi, Samantha K. Greaney
Supplementary Data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28a38f95a7d47fb4f42ac46e7f9e5046
https://doi.org/10.1158/2326-6066.22543342.v1
https://doi.org/10.1158/2326-6066.22543342.v1