Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Lawrence C. Sowers"'
Autor:
James W. Conrad, Mark L. Sowers, Dianne Y. Yap, Ellie Cherryhomes, B. Montgomery Pettitt, Kamil Khanipov, Lawrence C. Sowers
Publikováno v:
Biomolecules, Vol 13, Iss 9, p 1308 (2023)
Increased expression of the human telomere reverse transcriptase (hTERT) in tumors promotes tumor cell survival and diminishes the survival of patients. Cytosine-to-thymine (C-to-T) transition mutations (C250T or C228T) in the hTERT promoter create b
Externí odkaz:
https://doaj.org/article/4bc5f189d353409db9ab8edea379c2ed
Autor:
Tuvshintugs Baljinnyam, Mark L. Sowers, Chia Wei Hsu, James W. Conrad, Jason L. Herring, Linda C. Hackfeld, Lawrence C. Sowers
Publikováno v:
PLoS ONE, Vol 17, Iss 8 (2022)
The DNA of all living organisms is persistently damaged by endogenous reactions including deamination and oxidation. Such damage, if not repaired correctly, can result in mutations that drive tumor development. In addition to chemical damage, recent
Externí odkaz:
https://doaj.org/article/86c08afd0f114ea2a8e78c2cf701751c
Autor:
Mark L. Sowers, James W. Conrad, Bruce Chang-Gu, Ellie Cherryhomes, Linda C. Hackfeld, Lawrence C. Sowers
Publikováno v:
Molecules, Vol 28, Iss 3, p 970 (2023)
Although genomic DNA is predominantly duplex under physiological conditions, particular sequence motifs can favor the formation of alternative secondary structures, including the G-quadruplex. These structures can exist within gene promoters, telomer
Externí odkaz:
https://doaj.org/article/a33412c3fbe443a6b6675c6400251f67
Autor:
Mark L. Sowers, Lawrence C. Sowers
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 13, p 7156 (2022)
Glioblastoma is a fatal brain tumor with a bleak prognosis. The use of chemotherapy, primarily the alkylating agent temozolomide, coupled with radiation and surgical resection, has provided some benefit. Despite this multipronged approach, average pa
Externí odkaz:
https://doaj.org/article/855bd509d47a4e7e98c60513dcfd64f6
Autor:
Tuvshintugs Baljinnyam, James W. Conrad, Mark L. Sowers, Bruce Chang-Gu, Jason L. Herring, Linda C. Hackfeld, Kangling Zhang, Lawrence C. Sowers
Publikováno v:
Chemical Research in Toxicology. 36:162-176
Autor:
Sabine Lagger, John C Connelly, Gabriele Schweikert, Shaun Webb, Jim Selfridge, Bernard H Ramsahoye, Miao Yu, Chuan He, Guido Sanguinetti, Lawrence C Sowers, Malcolm D Walkinshaw, Adrian Bird
Publikováno v:
PLoS Genetics, Vol 13, Iss 5, p e1006793 (2017)
Mutations in the gene encoding the methyl-CG binding protein MeCP2 cause several neurological disorders including Rett syndrome. The di-nucleotide methyl-CG (mCG) is the classical MeCP2 DNA recognition sequence, but additional methylated sequence tar
Externí odkaz:
https://doaj.org/article/1a9520b92d1044c68c65fae93e056e6c
Autor:
Chia Wei Hsu, James W Conrad, Mark L Sowers, Tuvshintugs Baljinnyam, Jason L Herring, Linda C Hackfeld, Sandra S Hatch, Lawrence C Sowers
Publikováno v:
Nucleic acids research. 50(13)
DNA damage drives genetic mutations that underlie the development of cancer in humans. Multiple pathways have been described in mammalian cells which can repair this damage. However, most work to date has focused upon single lesions in DNA. We presen
Autor:
Chia Wei Hsu, Mark L. Sowers, Tuvshintugs Baljinnyam, Jason L. Herring, Linda C. Hackfeld, Hui Tang, Kangling Zhang, Lawrence C. Sowers
Publikováno v:
The Journal of biological chemistry. 298(3)
The hydrolytic deamination of cytosine and 5-methylcytosine drives many of the transition mutations observed in human cancer. The deamination-induced mutagenic intermediates include either uracil or thymine adducts mispaired with guanine. While a sub
Autor:
James L. Sowers, Hui Tang, Yan Chen, Barsam Mirfattah, Lawrence C. Sowers, Kangling Zhang, Bing Tian, Daniel F. Machuca, Allan R. Brasier, Jason Herring, Pei Xu
Publikováno v:
Molecular & Cellular Proteomics. 16:1906-1921
Rapidly proliferating tumors are exposed to a hypoxic microenvironment because of their density, high metabolic consumption, and interruptions in blood flow because of immature angiogenesis. Cellular responses to hypoxia promote highly malignant and
Autor:
Doug DeWitt, Jungling Gao, Katalin Módis, Isabel López-García, Domokos Gerő, Gabor Olah, Ping Wu, Donald S. Prough, Kangling Zhang, Petra Szoleczky, Lawrence C. Sowers, Bartosz Szczesny, Csaba Szabó
Publikováno v:
British Journal of Pharmacology. 175:284-300
Background and purpose We hypothesized that an in vitro, stretch-based model of neural injury may be useful to identify compounds that decrease the cellular damage in neurotrauma. Experimental approach We screened three neural cell lines (B35, RN33B,