Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Lawrence C. Fritz"'
Autor:
Karen Lundgren, Roy Grecko, Srinivas Rao Kasibhatla, Kevin Hong, Adeela Kamal, Rachel Lough, Gregg Timony, Lawrence C. Fritz, Edgar H. Ulm, Marco A. Biamonte, Patricia Karjian, David J. Busch, Marcus F. Boehm, Robert K. Mansfield, Francis Burrows, John Brekken, Yingqing Ran, John Sensintaffar
Publikováno v:
Journal of Medicinal Chemistry. 50:2767-2778
Heat shock protein 90 (Hsp90) is a molecular chaperone protein implicated in stabilizing the conformation and maintaining the function of many cell-signaling proteins. Many oncogenic proteins are more dependent on Hsp90 in maintaining their conformat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::256512d0ba0657d93f9e55a9f6d48e83
https://doi.org/10.1021/jm050752+
https://doi.org/10.1021/jm050752+
Autor:
Kevin J. Tomaselli, Julia Herrmann, Robert O. Sayers, Joe C. Wu, Lalitha Kodandapani, Kathy G. Jahangiri, Craig D. Fisher, David T. Winn, Edward D. Robinson, Steven P. Meduna, Robert J. Ternansky, Pauline Yeo, Karen L. Valentino, Jose-Luis Diaz, Vincent J. Kalish, Steven D. Linton, Kristen Sebring, Robert A. Armstrong, Joseph F. Krebs, Niel C. Hoglen, Alfred P. Spada, Brad P. Hirakawa, Ning Chen, Brett R. Ullman, Brett Weylan Ching, Cheng-zhi Zhang, Xu Bai, Xin Gu, Kip Nalley, Long-Shiuh Chen, Patricia L. Gladstone, Jeff McQuiston, Teresa Aja, Todd Groessl, Donald S. Karanewsky, Suzanne Weeks, Lawrence C. Fritz, Patricia C. Contreras
Publikováno v:
Journal of Medicinal Chemistry. 48:6779-6782
A series of oxamyl dipeptides were optimized for pan caspase inhibition, anti-apoptotic cellular activity and in vivo efficacy. This structure-activity relationship study focused on the P4 oxamides and warhead moieties. Primarily on the basis of in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc05f6b9f812322c1ff557485178cfdb
https://doi.org/10.1021/jm050307e
https://doi.org/10.1021/jm050307e
Autor:
Lawrence C. Fritz, Lia Thao, Marcus F. Boehm, Francis Burrows, John Sensintaffar, Lin Zhang, Adeela Kamal
Publikováno v:
Nature. 425:407-410
Heat shock protein 90 (Hsp90) is a molecular chaperone that plays a key role in the conformational maturation of oncogenic signalling proteins, including HER-2/ErbB2, Akt, Raf-1, Bcr-Abl and mutated p531,2,3,4,5,6,7. Hsp90 inhibitors bind to Hsp90, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5a5ae199e05a03fb67b31bf09380e2e
https://doi.org/10.1038/nature01913
https://doi.org/10.1038/nature01913
Autor:
Anu Srinivasan, Lawrence C. Fritz, Joseph F. Krebs, Kevin J. Tomaselli, Joe C. Wu, Angela M. Wong
Publikováno v:
Biochemistry. 39:16056-16063
Heavy membrane preparations from 697 lymphoblastoid cells contain a tightly bound caspase zymogen. This heavy membrane-bound procaspase can be efficiently liberated from membrane preparations using detergents. Alternatively, the procaspase can be rap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85377f4820bad7c3fe9b3101fb133326
https://doi.org/10.1021/bi001007w
https://doi.org/10.1021/bi001007w
Autor:
Susan C. Nicholson, Carl Nathan, Stephen R. Grobmyer, Lawrence C. Fritz, Maxine Melchior, William P. Arend, Strite Potter, Robert C. Armstrong, Cem Gabay
Publikováno v:
Molecular Medicine. 5:585-594
Septic shock is a leading cause of mortality in intensive care units. No new interventions in the last 20 years have made a substantial impact on the outcome of patients with septic shock. Identification of inhibitable pathways that mediate death in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fca024d9263a3dac39fd5bf5f21d5970
https://doi.org/10.1007/bf03402071
https://doi.org/10.1007/bf03402071
Autor:
Anu Srinivasan, Gregory J. Gores, Lawrence C. Fritz, Pierre A. Clavien, Markus Selzner, Karen L. Valentino, Shiho Natori
Publikováno v:
Transplantation. 68:89-96
Cold ischemia/warm reperfusion (CI/WR) liver injury remains a problem in liver transplants. Sinusoidal endothelial cells (SEC) are a target of CI/WR injury, during which they undergo apoptosis. Because caspase proteases have been implicated in apopto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1808645941e8fcfd359ac3d90cd9cae
https://doi.org/10.1097/00007890-199907150-00018
https://doi.org/10.1097/00007890-199907150-00018
Autor:
Christian Leist, Kim Hoang, Anu Srinivasan, Donald S. Karanewsky, Tam Vu, Lawrence C. Fritz, Robert C. Armstrong, Joe C. Wu, Bryan Pham, Teresa Aja, Rob Sayers, Albert Schmitz, Angela M. Wong, Joseph F. Krebs, Aileen Aboy, Kevin J. Tomaselli
Publikováno v:
The Journal of Cell Biology
The mechanism by which membrane-bound Bcl-2 inhibits the activation of cytoplasmic procaspases is unknown. Here we characterize an intracellular, membrane-associated form of procaspase-3 whose activation is controlled by Bcl-2. Heavy membranes isolat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::789f6e636e676d741d6d8f50362f45a9
https://doi.org/10.1083/jcb.144.5.915
https://doi.org/10.1083/jcb.144.5.915
Autor:
William A. Horne, Gary Wilson, Tilman Oltersdorf, Steve Chang, Suzanne Weeks, Yan Wang, Julia Chang, Sabine Ottilie, Jose-Luis Diaz, Lawrence C. Fritz
Publikováno v:
Journal of Biological Chemistry. 272:30866-30872
Bad, an inducer of programmed cell death, was recently isolated from a mouse cDNA library by its ability to bind to the anti-apoptotic protein BCL-2. Sequence analysis suggested that Bad was a member of the BCL-2 gene family that encodes both inducer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b92481a703d16a50b3767c5974580669
https://doi.org/10.1074/jbc.272.49.30866
https://doi.org/10.1074/jbc.272.49.30866
Publikováno v:
Journal of Biological Chemistry. 272:30299-30305
Bcl-xL, an antiapoptotic member of the Bcl-2 family, inhibits programmed cell death in a broad variety of cell types. Recent reports have demonstrated that cytochrome c is released from mitochondria during apoptosis and have suggested that this relea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2edd1b824f49b119bc42d02b339a2e78
https://doi.org/10.1074/jbc.272.48.30299
https://doi.org/10.1074/jbc.272.48.30299
Autor:
Kevin J. Tomaselli, Smita Gaur, Emad S. Alnemri, Teresa Aja, Donald S. Karanewsky, Xu Bai, Kim Hoang, Robert C. Armstrong, Gerald Litwack, Lawrence C. Fritz
Publikováno v:
The Journal of Neuroscience. 17:553-562
Neuronal apoptosis occurs during nervous system development and after pathological insults to the adult nervous system. Inhibition of CED3/ICE-related proteases has been shown to inhibit neuronal apoptosisin vitroandin vivo, indicating a role for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db1bee7fc57d62d2812e35934ac24105
https://doi.org/10.1523/jneurosci.17-02-00553.1997
https://doi.org/10.1523/jneurosci.17-02-00553.1997