Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Lawrence B Holzman"'
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184575 (2017)
ADP-ribosylation factor 6 (ARF6) is a small GTPase necessary for regulating cellular structure, motility, and vesicle trafficking. In several cellular systems, ARF6 was shown to regulate actin dynamics in coordination with Rac1, a Rho small GTPase. W
Externí odkaz:
https://doaj.org/article/691e20ec253f4f4b81112c2bf6934323
Autor:
Yan Hao, Erin Frey, Choya Yoon, Hetty Wong, Douglas Nestorovski, Lawrence B Holzman, Roman J Giger, Aaron DiAntonio, Catherine Collins
Publikováno v:
eLife, Vol 5 (2016)
A broadly known method to stimulate the growth potential of axons is to elevate intracellular levels of cAMP, however the cellular pathway(s) that mediate this are not known. Here we identify the Dual Leucine-zipper Kinase (DLK, Wnd in Drosophila) as
Externí odkaz:
https://doaj.org/article/ac9221f744814f329a98443715a0432f
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e67839 (2013)
We previously reported that podocyte-specific deletion of Myh9 (conventional myosin heavy chain 2A) in C57BL/6 mice does not cause spontaneous kidney disease but instead results in a predisposition to glomerulosclerosis in response to a second model
Externí odkaz:
https://doaj.org/article/338f77596eed42bda454ea868193925f
Autor:
Duncan B Johnstone, Vijay Shegokar, Deepak Nihalani, Yogendra Singh Rathore, Leena Mallik, Ashish, Vasant Zare, H Omer Ikizler, Rajaram Powar, Lawrence B Holzman
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51546 (2012)
Among African-Americans, genome wide association revealed a strong correlation between the G1 and G2 alleles of APOL1 (apolipoproteinL1, also called trypanolytic factor) and kidney diseases including focal and segmental glomerulosclerosis, HIV-associ
Externí odkaz:
https://doaj.org/article/d3eafe78bd2e4112b7ecb99823f2f485
Autor:
Yijiang Chen, Jarcy Zee, Andrew R. Janowczyk, Jeremy Rubin, Paula Toro, Kyle J. Lafata, Laura H. Mariani, Lawrence B. Holzman, Jeffrey B. Hodgin, Anant Madabhushi, Laura Barisoni
Publikováno v:
Kidney360. 4:648-658
Autor:
Jarcy Zee, Qian Liu, Abigail R. Smith, Jeffrey B. Hodgin, Avi Rosenberg, Brenda W. Gillespie, Lawrence B. Holzman, Laura Barisoni, Laura H. Mariani
Publikováno v:
J Am Soc Nephrol
BACKGROUND: Heterogeneity in disease course and treatment response among patients with MCD/FSGS necessitates a granular evaluation of kidney tissue features. This study aimed to identify histologic and ultrastructural descriptors of structural change
Autor:
Heon Yung Gee, Carolin E. Sadowski, Pardeep K. Aggarwal, Jonathan D. Porath, Toma A. Yakulov, Markus Schueler, Svjetlana Lovric, Shazia Ashraf, Daniela A. Braun, Jan Halbritter, Humphrey Fang, Rannar Airik, Virginia Vega-Warner, Kyeong Jee Cho, Timothy A. Chan, Luc G. T. Morris, Charles ffrench-Constant, Nicholas Allen, Helen McNeill, Rainer Büscher, Henriette Kyrieleis, Michael Wallot, Ariana Gaspert, Thomas Kistler, David V. Milford, Moin A. Saleem, Wee Teik Keng, Stephen I. Alexander, Rudolph P. Valentini, Christoph Licht, Jun C. Teh, Radovan Bogdanovic, Ania Koziell, Agnieszka Bierzynska, Neveen A. Soliman, Edgar A. Otto, Richard P. Lifton, Lawrence B. Holzman, Nicholas E. S. Sibinga, Gerd Walz, Alda Tufro, Friedhelm Hildebrandt
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Steroid-sensitive nephrotic syndrome (SRNS) can cause CKD and necessitate kidney transplant. Here the authors identify FAT1 mutations by homozygosity mapping and whole-exome sequencing in families with SRNS and provide functional mouse and zebrafish
Externí odkaz:
https://doaj.org/article/28d36207928640028a9a892d5c32fd4f
APOL1 genotype-associated morphologic changes among patients with focal segmental glomerulosclerosis
Autor:
John F. O’Toole, Katherine R. Tuttle, Kevin V. Lemley, Matthew G. Sampson, Marie C. Hogan, Jarcy Zee, Michelle T McNulty, Sharon G. Adler, Vimal K. Derebail, Chia-shi Wang, Raed Bou Matar, Elizabeth J. Brown, Katherine MacRae Dell, Fernando C. Fervenza, Keisha L. Gibson, Gerald B. Appel, Cynthia C. Nast, Ambarish M. Athavale, Pamela Singer, Jonathan Ashley Jefferson, Richard A. Lafayette, Jeffrey B. Kopp, Larry A. Greenbaum, Kevin E.C. Meyers, Laura Barisoni, Alessia Fornoni, Jiten Patel, Kamalanathan K. Sambandam, Crystal A. Gadegbeku, Meredith A. Atkinson, Serena M. Bagnasco, Matthias Kretzler, Jonathan J. Hogan, Heather N. Reich, Suzanne Vento, Howard Trachtman, Jen Jar Lin, Jeffrey B. Hodgin, Lawrence B. Holzman, Tarak Srivastava, Sangeeta Hingorani, Frederick J. Kaskel, Michelle Hladunewich, Olga Zhdanova, Christine B. Sethna, Dhruti P. Chen, Debbie S. Gipson, John C. Lieske
Publikováno v:
Pediatr Nephrol
Background: The G1 and G2 alleles of apolipoprotein L1 (APOL1) are common in the Black population and associated with increased risk of focal segmental glomerulosclerosis (FSGS). The molecular mechanisms linking APOL1 risk variants with FSGS are not
Autor:
Kshama R. Mehta, Catherine P. Jayapandian, Alessia Fornoni, John R. Sedor, Sangeeta Hingorani, Barry I. Freedman, M. Bray, M. Schachere, Christine B. Sethna, L. Barisoni, A. Cooper, Matthias Kretzler, Miroslav Sekulic, Anne Froment, Lawrence A. Greenbaum, J. Blake, Jeffrey B. Kopp, M. Toledo, Yijiang Chen, J. Lalli, Richard A. Lafayette, M. Romano, Duncan B. Johnstone, Katherine R. Tuttle, Katherine MacRae Dell, Kamal Sambandam, Matthew B. Palmer, Marie C. Hogan, J. LaVigne, Frederick J. Kaskel, E. Lim, M. Rogers, Z. Wang, J. Negrey, S. Boynton, Fernando C. Fervenza, Deb Gipson, Vimal K. Derebail, Anant Madabhushi, Sharon G. Adler, Stephen M. Hewitt, Jen Jar Lin, Cynthia C. Nast, John H. Stroger, Clarissa A. Cassol, S. Grubbs, Laura Barisoni, Kevin E.C. Meyers, C. Kang, Jeffrey B. Hodgin, Paula Toro, Ambarish M. Athavale, Frank Modersitzki, Mathew Itteera, Olga Zhdanova, John C. Lieske, Heather N. Reich, G B Appel, John F. O’Toole, Howard Trachtman, S. Quinn-Boyle, Andrew Janowczyk, Suzanne Vento, Alicia M. Neu, Vladimir Chernitskiy, A. Jefferson, M. Kelton, Dan Cattran, Crystal A. Gadegbeku, P. Flynn, N. Kumar, Krishna Kallem, C. Bidot, Michelle Hladunewich, Keisha L. Gibson, Kevin V. Lemley, J. LaPage, A. Garrett, Lawrence B. Holzman, A. Williams, Tarak Srivastava, P. Ling, Jarcy Zee, K. Laurent, Chia-shi Wang
Publikováno v:
Kidney International. 99:86-101
The application of deep learning for automated segmentation (delineation of boundaries) of histologic primitives (structures) from whole slide images can facilitate the establishment of novel protocols for kidney biopsy assessment. Here, we developed
Autor:
Shannon L. Murphy, John D. Mahan, Jonathan P. Troost, Tarak Srivastava, Amy J. Kogon, Yi Cai, T. Keefe Davis, Hilda Fernandez, Alessia Fornoni, Rasheed A. Gbadegesin, Emily Herreshoff, Pietro A. Canetta, Patrick H. Nachman, Bryce B. Reeve, David T. Selewski, Christine B. Sethna, Chia-shi Wang, Sharon M. Bartosh, Debbie S. Gipson, Katherine R. Tuttle, Ali Gharavi, Wooin Ahn, Gerald B. Appel, Rupali S. Avasare, Revekka Babayev, Ibrahim Batal, Andrew S. Bomback, Eric Brown, Eric S. Campenot, Pietro Canetta, Brenda Chan, Vivette D. D’Agati, Bartosz Foroncewicz, Gian Marco Ghiggeri, William H. Hines, Namrata G. Jain, Krzysztof Kiryluk, Fangming Lin, Francesca Lugani, Maddalena Marasa, Glen Markowitz, Sumit Mohan, Krzysztof Mucha, Thomas L. Nickolas, Jai Radhakrishnan, Maya K. Rao, Renu Regunathan-Shenk, Simone Sanna-Cherchi, Dominick Santoriello, Michael B. Stokes, Natalie Yu, Anthony M. Valeri, Ronald Zviti, Larry A. Greenbaum, William E. Smoyer, Amira Al-Uzri, Isa Ashoor, Diego Aviles, Rossana Baracco, John Barcia, Sharon Bartosh, Craig Belsha, Michael C. Braun, Aftab Chishti, Donna Claes, Carl Cramer, Keefe Davis, Elif Erkan, Daniel Feig, Michael Freundlich, Melisha Hanna, Guillermo Hidalgo, Amrish Jain, Myda Khalid, Mahmoud Kallash, Jerome C. Lane, John Mahan, Nisha Mathews, Carla Nester, Cynthia Pan, Hiren Patel, Adelaide Revell, Rajasree Sreedharan, Julia Steinke, Scott E. Wenderfer, Craig S. Wong, Ronald Falk, William Cook, Vimal Derebail, Agnes Fogo, Adil Gasim, Todd Gehr, Raymond Harris, Jason Kidd, Louis-Philippe Laurin, Will Pendergraft, Vincent Pichette, Thomas Brian Powell, Matthew B. Renfrow, Virginie Royal, Lawrence B. Holzman, Sharon Adler, Charles Alpers, Raed Bou Matar, Elizabeth Brown, Michael Choi, Katherine M. Dell, Ram Dukkipati, Fernando C. Fervenza, Crystal Gadegbeku, Patrick Gipson, Leah Hasely, Sangeeta Hingorani, Michelle A. Hladunewich, Jonathan Hogan, J. Ashley Jefferson, Kenar Jhaveri, Duncan B. Johnstone, Frederick Kaskel, Amy Kogan, Jeffrey Kopp, Kevin V. Lemley, Laura Malaga- Dieguez, Kevin Meyers, Alicia Neu, Michelle Marie O'Shaughnessy, John F. O’Toole, Rulan Parekh, Heather Reich, Kimberly Reidy, Helbert Rondon, Kamalanathan K. Sambandam, John R. Sedor, Jeffrey Schelling, John C. Sperati, Agnes Swiatecka-Urban, Howard Trachtman, Joseph Weisstuch, Olga Zhdanova, Brenda Gillespie, Matthias Kretzler, Bruce M. Robinson, Laura Mariani, Matthew Wladkowski, Lisa M. Guay-Woodford
Publikováno v:
Kidney International Reports, Vol 5, Iss 10, Pp 1679-1689 (2020)
Kidney International Reports
Kidney International Reports
Introduction: Prior cross-sectional studies suggest that health-related quality of life (HRQOL) worsens with more severe glomerular disease. This longitudinal analysis was conducted to assess changes in HRQOL with changing disease status. Methods: Cu