Zobrazeno 1 - 10
of 413
pro vyhledávání: '"Lawrence A. Loeb"'
Autor:
Jesse J. Salk, Kaitlyn Loubet-Senear, Elisabeth Maritschnegg, Charles C. Valentine, Lindsey N. Williams, Jacob E. Higgins, Reinhard Horvat, Adriaan Vanderstichele, Daniela Nachmanson, Kathryn T. Baker, Mary J. Emond, Emily Loter, Maria Tretiakova, Thierry Soussi, Lawrence A. Loeb, Robert Zeillinger, Paul Speiser, Rosa Ana Risques
Publikováno v:
Cell Reports, Vol 28, Iss 1, Pp 132-144.e3 (2019)
Summary: High-accuracy next-generation DNA sequencing promises a paradigm shift in early cancer detection by enabling the identification of mutant cancer molecules in minimally invasive body fluid samples. We demonstrate 80% sensitivity for ovarian c
Externí odkaz:
https://doaj.org/article/321fc6803f4e46e7a0f6986070caf555
Publikováno v:
BioTechniques, Vol 38, Iss 2, Pp 257-264 (2005)
The incorporation of fluorescently labeled nucleotides into DNA by DNA polymerases has been used extensively for tagging genes and for labeling DNA. However, we lack studies comparing polymerase efficiencies for incorporating different fluorescently
Externí odkaz:
https://doaj.org/article/09399cc14fe4413fb6c3560206636d3a
Publikováno v:
BioTechniques, Vol 33, Iss 5, Pp 1136-1144 (2002)
Mutant DNA polymerases have become an increasingly important tool in biotechnology. The ability to examine the activity and specific properties of enzymes has a crucial role in the characterization of the enzyme. We have developed several systems for
Externí odkaz:
https://doaj.org/article/d03544f372bb4ce79517e1d01dc21f22
Seven supplementary tables. Table S1. Data yield and Duplex Sequencing statistics. Table S2. Mutation contexts significantly differ between normal stem cells and transformed cells. Table S3. Homoplasmic variants in the whole mtDNA identified using Du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1716498fa9e50129aaf9e928d14f66ce
https://doi.org/10.1158/0008-5472.22413962.v1
https://doi.org/10.1158/0008-5472.22413962.v1
Supplementary methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23239fcab01be9965049dbdc86b7fa69
https://doi.org/10.1158/0008-5472.22413965.v1
https://doi.org/10.1158/0008-5472.22413965.v1
Figure legends for Supplementary figures 1, 2, and 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34742c7c8163c88caaf67145968fa8c6
https://doi.org/10.1158/0008-5472.22413968.v1
https://doi.org/10.1158/0008-5472.22413968.v1
Mutation signature correlation graph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::543ff581884cdee080b379e1884540ab
https://doi.org/10.1158/0008-5472.22413977
https://doi.org/10.1158/0008-5472.22413977
Rare stochastic mutations may accumulate during dormancy of stem-like cells, but technical limitations in DNA sequencing have limited exploring this possibility. In this study, we employed a recently established deep-sequencing method termed Duplex S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c434d422b2bdbde4e52df792ec1cff8
https://doi.org/10.1158/0008-5472.c.6508862.v1
https://doi.org/10.1158/0008-5472.c.6508862.v1
Rare and low heteroplasmic mutations frequency and mutation (%) fraction graphs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d4d8893683beec91428a92bdca128cc
https://doi.org/10.1158/0008-5472.22413980.v1
https://doi.org/10.1158/0008-5472.22413980.v1