Zobrazeno 1 - 10
of 148
pro vyhledávání: '"Lawrence A. Kane"'
Autor:
Ki Sun Kim, Chanju Lee, Hyung-Seok Kim, Su Jeong Gu, Hee Jung Yoon, Su Bin Won, Ho Lee, Yong Sun Lee, Sang Soo Kim, Lawrence P. Kane, Eun Jung Park
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-18 (2024)
Abstract T cell immunoglobulin and mucin-containing molecule 3 (TIM-3) exhibits unique, cell type- and context-dependent characteristics and functions. Here, we report that TIM-3 on myeloid cells plays essential roles in modulating lung inflammation.
Externí odkaz:
https://doaj.org/article/53f32d3906374b9e85cb48c89f50e444
Autor:
Sean Robinson, Andrea L Szymczak-Workman, Hridesh Banerjee, Lawrence P Kane, Benjamin M Murter
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/28ddcfb0ef2e4ce1b5073aebcaab2b95
Autor:
Xin Zhang, Lazar Vujanovic, Riyue Bao, Robert Ferris, Tullia Bruno, Jennifer Anderson, Aditi Kulkarni, Hridesh Banerjee, Housaiyin Li, Juncheng Wang, Lidia Arantes, Lawrence P Kane
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/b01a25b35c6c4cd289ad1012c51ef467
Autor:
Ornella Pagliano, Robert M. Morrison, Joe-Marc Chauvin, Hridesh Banerjee, Diwakar Davar, Quanquan Ding, Tokiyoshi Tanegashima, Wentao Gao, Saranya R. Chakka, Richelle DeBlasio, Ava Lowin, Kevin Kara, Mignane Ka, Bochra Zidi, Rada Amin, Itay Raphael, Shuowen Zhang, Simon C. Watkins, Cindy Sander, John M. Kirkwood, Marcus Bosenberg, Ana C. Anderson, Vijay K. Kuchroo, Lawrence P. Kane, Alan J. Korman, Arvind Rajpal, Sean M. West, Minhua Han, Christine Bee, Xiaodi Deng, Xiao Min Schebye, Pavel Strop, Hassane M. Zarour
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 9 (2022)
T cell immunoglobulin mucin domain-containing protein 3 (Tim-3) negatively regulates innate and adaptive immunity in cancer. To identify the mechanisms of Tim-3 in cancer immunity, we evaluated the effects of Tim-3 blockade in human and mouse melanom
Externí odkaz:
https://doaj.org/article/00341078d5a94f57ba93043742d00efb
Autor:
Hridesh Banerjee, Hector Nieves-Rosado, Aditi Kulkarni, Benjamin Murter, Kyle V. McGrath, Uma R. Chandran, Alexander Chang, Andrea L. Szymczak-Workman, Lazar Vujanovic, Greg M. Delgoffe, Robert L. Ferris, Lawrence P. Kane
Publikováno v:
Cell Reports, Vol 36, Iss 11, Pp 109699- (2021)
Summary: Regulatory T cells (Treg cells) are critical mediators of self-tolerance, but they can also limit effective anti-tumor immunity. Although under homeostasis a small fraction of Treg cells in lymphoid organs express the putative checkpoint mol
Externí odkaz:
https://doaj.org/article/44dc63899c1d47c7bb8e826cd9767e89
Autor:
Gerard J. Nau, Joseph Horzempa, Dawn O’Dee, Matthew J. Brown, Brian C. Russo, Ana Hernandez, Simon T. Dillon, Jing Cheng, Lawrence P. Kane, Subramaniam Sanker, Neil A. Hukriede
Publikováno v:
Virulence, Vol 10, Iss 1, Pp 643-656 (2019)
Pathogens enhance their survival during infections by manipulating host defenses. Francisella tularensis evades innate immune responses, which we have found to be dependent on an understudied gene ybeX (FTL_0883/FTT_0615c). To understand the function
Externí odkaz:
https://doaj.org/article/53a0193c29d24e789078a350b2142165
Autor:
Angela M. Gocher-Demske, Jian Cui, Andrea L. Szymczak-Workman, Kate M. Vignali, Julianna N. Latini, Gwen P. Pieklo, Jesse C. Kimball, Lyndsay Avery, Ellyse M. Cipolla, Brydie R. Huckestein, Lee Hedden, Marlies Meisel, John F. Alcorn, Lawrence P. Kane, Creg J. Workman, Dario A. A. Vignali
Publikováno v:
Nat Immunol
Regulatory T (T(reg)) cells are an immunosuppressive population that are required to maintain peripheral tolerance and prevent tissue damage from immunopathology, via anti-inflammatory cytokines, inhibitor receptors and metabolic disruption. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::317856fa71787b2cd7f75b69af66d144
https://doi.org/10.1038/s41590-023-01453-w
https://doi.org/10.1038/s41590-023-01453-w
Autor:
Benjamin Murter, Lawrence P. Kane
Publikováno v:
F1000Research, Vol 9 (2020)
Virtually all aspects of T and B lymphocyte development, homeostasis, activation, and effector function are impacted by the interaction of their clonally distributed antigen receptors with antigens encountered in their respective environments. Antige
Externí odkaz:
https://doaj.org/article/a56a93c79ff648fcafaf7e9c63773d89
Autor:
Roger Tieu, Qiang Zeng, Daqiang Zhao, Gang Zhang, Neda Feizi, Priyanka Manandhar, Amanda L. Williams, Benjamin Popp, Michelle A. Wood-Trageser, Anthony J. Demetris, J. Yun Tso, Aaron J. Johnson, Lawrence P. Kane, Khodor I. Abou-Daya, Warren D. Shlomchik, Martin H. Oberbarnscheidt, Fadi G. Lakkis
Publikováno v:
Science Immunology. 8
Our understanding of tissue-resident memory T (T RM ) cell biology has been largely developed from acute infection models in which antigen is cleared and sterilizing immunity is achieved. Less is known about T RM cells in the context of chronic antig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00786e2566c98e1c677ee67679c6cc43
https://doi.org/10.1126/sciimmunol.add8454
https://doi.org/10.1126/sciimmunol.add8454
Autor:
Robert L. Ferris, Binfeng Lu, Lawrence P. Kane, Raghvendra Srivastava, Kevin Chen, Jing Li, Gulidanna Shayan, Elizabeth L. McMichael, Zhuqing Liu
For IL-10, Granzyme B and IFN-γ quantification, bulk TIL were stimulated in vitro with anti-CD3/CD28 beads and protein transport inhibitor (BD GolgiPlugTM) for 6h.Cells were then stained for intracellular cytokine expression by flow cytometry. Summa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21d7799db8b71f7c8261cf4979e59f24
https://doi.org/10.1158/1078-0432.22463949
https://doi.org/10.1158/1078-0432.22463949
