Výsledky vyhledávání - "Lawrence A. Hunt"

Akademický článek

Evolution of an expanded mannose receptor gene family.

Autor: Karen Staines, Lawrence G Hunt, John R Young, Colin Butter

Publikováno v: PLoS ONE, Vol 9, Iss 11, p e110330 (2014)

Sequences of peptides from a protein specifically immunoprecipitated by an antibody, KUL01, that recognises chicken macrophages, identified a homologue of the mammalian mannose receptor, MRC1, which we called MRC1L-B. Inspection of the genomic enviro

Externí odkaz: https://doaj.org/article/db74b82d3e604f10b1e646c7331e1a18

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Lysine hydroxylation and O-glycosylation in the globular, C-terminal region of mammalian-expressed, recombinant PrP

Autor: Lawrence G. Hunt, Andrew C. Gill, Mark Ritchie

Publikováno v: International Journal of Mass Spectrometry. :132-141

Conversion of PrPC, the prion protein, to a conformationally altered isoform, PrPSc, is the major pathogenic event in the transmissible spongiform encephalopathies, a family of neurodegenerative diseases including bovine spongiform encephalopathy, Cr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b94516e74935a19ece38ba5782631e36
https://doi.org/10.1016/j.ijms.2012.08.015

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Proteomic comparison of four Eimeria tenella life-cycle stages: unsporulated oocyst, sporulated oocyst, sporozoite and second-generation merozoite

Autor: Robert E. Sinden, Richard D. Oakes, Sanya J. Sanderson, Kalpana Lal, Jonathan M. Wastling, John R. Yates, Dominic Kurian, Lawrence G. Hunt, Judith Helena Prieto, Fiona M. Tomley, Elizabeth Bromley

We report the proteomes of four life-cycle stages of the Apicomplexan parasite Eimeria tenella. A total of 1868 proteins were identified, with 630, 699, 845 and 1532 found in early oocysts (unsporulated), late oocysts (sporulated), sporozoites and se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aef221df980ebb503a2a927e0cff7b0
https://ora.ox.ac.uk/objects/uuid:c71b667b-b875-4a2c-957b-931cab38c4a2

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Surface expression, peptide repertoire, and thermostability of chicken class I molecules correlate with peptide transporter specificity

Autor: Lawrence G. Hunt, Olli Vainio, James C. Kaufman, Andy van Hateren, Michael Harrison, Clive A. Tregaskes, Anna K. Sowa

The chicken major histocompatibility complex (MHC) has strong genetic associations with resistance and susceptibility to certain infectious pathogens. The cell surface expression level of MHC class I molecules varies as much as 10-fold between chicke

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0cfb807e6b417b872968d4c14c38650
https://europepmc.org/articles/PMC4725490/

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The dominantly expressed class I molecule of the chicken MHC is explained by coevolution with the polymorphic peptide transporter (TAP) genes

Autor: Lawrence G. Hunt, Karsten Skjødt, Anna K. Sowa, Paul J. Lehner, James C. Kaufman, Brian A Walker, Thomas W. Göbel

Publikováno v: Walker, B A, Hunt, L G, Sowa, A K, Skjødt, K, Göbel, T W, Lehner, P J & Kaufman, J 2011, ' The dominantly expressed class I molecule of the chicken MHC is explained by coevolution with the polymorphic peptide transporter (TAP) genes ', Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 20, pp. 8396-8401 . https://doi.org/10.1073/pnas.1019496108

In most mammals, the MHC class I molecules are polymorphic and determine the specificity of peptide presentation, whereas the transporter associated with antigen presentation (TAP) heterodimers are functionally monomorphic. In chickens, there are two

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50e42daa71c25c42b543da0e71c3edbd
https://doi.org/10.1073/pnas.1019496108

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Fibrinogen is localized on dark zone follicular dendritic cells in vivo and enhances the proliferation and survival of a centroblastic cell line in vitro

Autor: L. S. Brackenbury, Lawrence G. Hunt, Paul Monaghan, Eric A. Lefevre, Emma A. Supple, Zania Stamataki, Yolande Richard, Wayne R. Hein, Bryan Charleston, Gwenoline Borhis

Publikováno v: Journal of Leukocyte Biology. 82:666-677

Follicular dendritic cells (FDC) in the germinal centers (GC) of secondary lymphoid or- gans increase the survival and proliferation of an- tigen-stimulated B cells and are pivotal for the affinity maturation of an antibody response and for maintenan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47b59654039523ab9fad56c44a3e7c22
https://doi.org/10.1189/jlb.0107050

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The Vaccinia Virus N1L Protein Influences Cytokine Secretion in Vitro after Infection

Autor: Zhouning Zhang, Girish J. Kotwal, Melissa-Rose Abrahams, Jill Suttles, Debomoy K. Lahiri, Lawrence A. Hunt, William L. Marshall

Publikováno v: Annals of the New York Academy of Sciences. 1056:69-86

The vaccinia virus N1L ORF encodes a protein that enhances virulence and replication of the virus by an unknown mechanism. It has been studied for its ability to enhance viral replication and dissemination in the brain and more recently has been link

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::974d7b17a9f68c4245e46f2d7f21c030
https://doi.org/10.1196/annals.1352.005

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Conservation of biological properties of the CD40 ligand, CD154 in a non-mammalian vertebrate

Autor: Harrie L. Glansbeek, Joan Burnside, John R. Young, Andrew C. Gill, Lawrence G. Hunt, Clive A. Tregaskes

Publikováno v: Tregaskes, C A, Glansbeek, H L, Gill, A C, Hunt, L G, Burnside, J & Young, J R 2005, ' Conservation of biological properties of the CD40 ligand, CD154 in a non-mammalian vertebrate ', Developmental and Comparative Immunology, vol. 29, no. 4, pp. 361-374 . https://doi.org/10.1016/j.dci.2004.09.001

Signals delivered by the CD40 ligand, CD154, have crucial roles in immune responses in mammals, being required for development of germinal centres, maturation of T-dependent antibody responses, and generation of B-cell memory. To determine whether th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5822581b823d1f3aa2a39afe58991fb7
https://doi.org/10.1016/j.dci.2004.09.001

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Marek's disease is a natural model for lymphomas overexpressing Hodgkin's disease antigen (CD30)

Autor: C. A. Tregaskes, Mark S. Parcells, L. N. J. Ross, Lucy F. Lee, Lawrence G. Hunt, Shane C. Burgess, B. J. G. Baaten, T. F. Davison, Pradeep Kumar, John R. Young

Publikováno v: Proceedings of the National Academy of Sciences. 101:13879-13884

Animal models are essential for elucidating the molecular mechanisms of carcinogenesis. Hodgkin's and many diverse non-Hodgkin's lymphomas overexpress the Hodgkin's disease antigen CD30 (CD30hi), a tumor necrosis factor receptor II family member. Her

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c0c437b57b3a0e2b49757a8b1409343
https://doi.org/10.1073/pnas.0305789101

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