Zobrazeno 1 - 10
of 207
pro vyhledávání: '"Lawrence A Quilliam"'
Autor:
Tamica N Collins, Yingyu Mao, Hongge Li, Michael Bouaziz, Angela Hong, Gen-Sheng Feng, Fen Wang, Lawrence A Quilliam, Lin Chen, Taeju Park, Tom Curran, Xin Zhang
Publikováno v:
eLife, Vol 7 (2018)
Specific cell shapes are fundamental to the organization and function of multicellular organisms. Fibroblast Growth Factor (FGF) signaling induces the elongation of lens fiber cells during vertebrate lens development. Nonetheless, exactly how this ex
Externí odkaz:
https://doaj.org/article/103552b2bf844c2ab53e6ef5980e37ed
Autor:
Haibo Wang, Xiaokun Han, Colin A Bretz, Silke Becker, Deeksha Gambhir, George W Smith, R Jude Samulski, Erika S Wittchen, Lawrence A Quilliam, Magdalena Chrzanowska-Wodnicka, M Elizabeth Hartnett
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
To test the hypothesis that increased Rap1a activity specifically in retinal pigment epithelial cells resists choroidal neovascularization (CNV), self-complementary adeno-associated virus 2 (scAAV2) with RPE65-promoter-driven GFP vectors were generat
Externí odkaz:
https://doaj.org/article/cd8e2b0f679940ba84f1a0b4c6314f90
Autor:
Maria Elena Sana, Lawrence A Quilliam, Andrea Spitaleri, Laura Pezzoli, Daniela Marchetti, Chiara Lodrini, Elisabetta Candiago, Anna Rita Lincesso, Paolo Ferrazzi, Maria Iascone
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168501 (2016)
Several genetic conditions can lead to left ventricular hypertrophy (LVH). Among them, hypertrophic cardiomyopathy (HCM), caused by mutations in sarcomere genes, is the most common inherited cardiac disease. Instead, RASopathies, a rare class of diso
Externí odkaz:
https://doaj.org/article/59f93c5d8703448d9140bb170666ea05
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145689 (2015)
BACKGROUND:Small GTPase Rap1 has been implicated in a number of basic cellular functions, including cell-cell and cell-matrix adhesion, proliferation and regulation of polarity. Evolutionarily conserved, Rap1 has been studied in model organisms: yeas
Externí odkaz:
https://doaj.org/article/4f97e187dfea472b825ed3b32fcfdbcd
Autor:
Michael C Schmid, Irene Franco, Sang Won Kang, Emilio Hirsch, Lawrence A Quilliam, Judith A Varner
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60226 (2013)
Tumor inflammation, the recruitment of myeloid lineage cells into the tumor microenvironment, promotes angiogenesis, immunosuppression and metastasis. CD11b+Gr1lo monocytic lineage cells and CD11b+Gr1hi granulocytic lineage cells are recruited from t
Externí odkaz:
https://doaj.org/article/126fbdd34f2c45f098b1596392423f77
Rap1 GTPase activation and barrier enhancement in rpe inhibits choroidal neovascularization in vivo.
Autor:
Erika S Wittchen, Eiichi Nishimura, Manabu McCloskey, Haibo Wang, Lawrence A Quilliam, Magdalena Chrzanowska-Wodnicka, M Elizabeth Hartnett
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73070 (2013)
Loss of barrier integrity precedes the development of pathologies such as metastasis, inflammatory disorders, and blood-retinal barrier breakdown present in neovascular age-related macular degeneration. Rap1 GTPase is involved in regulating both endo
Externí odkaz:
https://doaj.org/article/dff2b957dacd4c43a09499e98f460a81
Autor:
Lawrence A. Quilliam
Publikováno v:
Encyclopedia of Biological Chemistry III ISBN: 9780128220405
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5ab45ec3305b0472850d96414cbe24e
https://doi.org/10.1016/b978-0-12-819460-7.00115-8
https://doi.org/10.1016/b978-0-12-819460-7.00115-8
Autor:
Donna Coffey, Kenneth P. Nephew, John P. Lydon, Andrew K. Godwin, Shannon M. Hawkins, Robert E. Emerson, Kathy D. Miller, Francesco J. DeMayo, Lawrence A. Quilliam, Martin Widschwendter, Anil K. Sood, Chi Heum Cho, Olga Kim, Adam R. Karpf, Jaeyeon Kim, S. Shin, Robert C. Bast, Yong-Hyun Shin, Eun Young Park, Sun Young Kwon, Facundo M. Fernández, Dong-Joo Cheon
Publikováno v:
Proc Natl Acad Sci U S A
PNAS
PNAS
SignificanceWhy women carrying a pathogenic germlineBRCA1mutation are predisposed to ovarian and breast cancer remains elusive. This study points to ovarian progesterone as a culprit. Generally,BRCA1-mutation carriers exhibit high yet individually va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6329d59a8fdd1cea8ebd6f4b537d481a
https://europepmc.org/articles/PMC7749341/
https://europepmc.org/articles/PMC7749341/
Autor:
Tamica N Collins, Yingyu Mao, Hongge Li, Michael Bouaziz, Angela Hong, Gen-Sheng Feng, Fen Wang, Lawrence A Quilliam, Lin Chen, Taeju Park, Tom Curran, Xin Zhang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::357db0c2ae74dbbff4c5187c7b2e2aa9
https://doi.org/10.7554/elife.32586.019
https://doi.org/10.7554/elife.32586.019