Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Lawrence, de Garavilla"'
Autor:
Zhirong Fu, Srinivas Akula, Chang Qiao, Jinhye Ryu, Gurdeep Chahal, Lawrence de Garavilla, Jukka Kervinen, Michael Thorpe, Lars Hellman
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0252624 (2021)
Ruminants have a very complex digestive system adapted for the digestion of cellulose rich food. Gene duplications have been central in the process of adapting their digestive system for this complex food source. One of the new loci involved in food
Externí odkaz:
https://doaj.org/article/e0f237f1b481422a93ba018753e5b067
Autor:
Michael Thorpe, Zhirong Fu, Emanuelle Albat, Srinivas Akula, Lawrence de Garavilla, Jukka Kervinen, Lars Hellman
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0207826 (2018)
Serine proteases constitute the major protein content of mast cell secretory granules. Here we present the extended cleavage specificity of two such proteases from the golden hamster, Mesocricetus auratus. Analysis by phage display technique showed t
Externí odkaz:
https://doaj.org/article/b690572565db40feba9bcae606e647fc
Autor:
Michael Thorpe, Zhirong Fu, Gurdeep Chahal, Srinivas Akula, Jukka Kervinen, Lawrence de Garavilla, Lars Hellman
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195077 (2018)
Human neutrophils express at least four active serine proteases, cathepsin G, N-elastase, proteinase 3 and neutrophil serine protease 4 (NSP4). They have all been extensively studied due to their importance in neutrophil biology and immunity. However
Externí odkaz:
https://doaj.org/article/103d3679263643d2b64533a20d89f79f
Autor:
Gurdeep Chahal, Lars Hellman, Srinivas Akula, Michael Thorpe, Lawrence de Garavilla, Zhirong Fu, Jukka Kervinen
Publikováno v:
Developmental & Comparative Immunology. 92:160-169
Serine proteases constitute the major protein content of mammalian mast cell granules and the selectivity for substrates by these proteases is of major importance for the role of mast cells in immunity. In order to address this subject, we present he
Autor:
Jukka Kervinen, Srinivas Akula, Jinhye Ryu, Michael Thorpe, Lars Hellman, Zhirong Fu, Chang Qiao, Gurdeep Chahal, Lawrence de Garavilla
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 5, p e0252624 (2021)
PLoS ONE, Vol 16, Iss 5, p e0252624 (2021)
Ruminants have a very complex digestive system adapted for the digestion of cellulose rich food. Gene duplications have been central in the process of adapting their digestive system for this complex food source. One of the new loci involved in food
Autor:
Zhirong Fu, Yuan Zhongwei, Lars Hellman, Srinivas Akula, Michael Thorpe, Jukka Kervinen, Lawrence de Garavilla
Publikováno v:
International Journal of Molecular Sciences
Volume 20
Issue 24
Volume 20
Issue 24
Serine proteases constitute the major protein content of mast cell (MC) secretory granules. These proteases can generally be subdivided into chymases and tryptases based on their primary cleavage specificity. Here, we presented the extended cleavage
Autor:
Zhirong Fu, Jukka Kervinen, Rahel Alemayehu, Michael Thorpe, Lars Hellman, Magnus Åbrink, Ananya Roy, Lawrence de Garavilla
Human mast cell chymase (HC) and human neutrophil cathepsin G (hCG) show relatively similar cleavage specificities: they both have chymotryptic activity but can also cleave efficiently after leucine. Their relatively broad specificity suggests that t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e86bb4772d24df7107414fe30331d18
https://publica.fraunhofer.de/handle/publica/251840
https://publica.fraunhofer.de/handle/publica/251840
Publikováno v:
The Journal of Physiology. 588:1171-1177
The nature of protease-activated receptors (PARs) capable of activating respiratory vagal C-fibres in the mouse was investigated. Infusing thrombin or trypsin via the trachea strongly activated vagal lung C-fibres with action potential discharge, rec
Autor:
Patricia Andrade-Gordon, Barbara J. Haertlein, Bruce P. Damiano, Bruce E. Maryanoff, Michael J. Costanzo, Edward C. Giardino, Lawrence de Garavilla
Publikováno v:
Blood Coagulation & Fibrinolysis. 21:128-134
Whereas heparin functions as an antithrombotic agent by promoting antithrombin III-based inhibition of thrombin and factor Xa, there is less appreciation for the combination behavior with small-molecule, direct inhibitors of these proteases. We condu
Autor:
Andrew D. Mahan, Stanley M. Belkowski, Lawrence de Garavilla, Jukka Kervinen, John A. Masucci, Matthew Olson, Michael R. D'Andrea
Publikováno v:
bchm. 389:1219-1224
Secretory leukocyte protease inhibitor (SLPI) is a protease inhibitor of the whey acidic protein-like family inhibiting chymase, chymotrypsin, elastase, proteinase 3, cathepsin G and tryptase. Performing in vitro enzymatic assays using both Western b