A comparative study of histotripsy parameters for the treatment of fibrotic ex-vivo human benign prostatic hyperplasia tissue

Autor: Yashwanth Nanda Kumar, Zorawar Singh, Yak-Nam Wang, Diboro Kanabolo, Lucas Chen, Matthew Bruce, Eli Vlaisavljevich, Lawrence True, Adam D. Maxwell, George R. Schade

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)

Abstract Histotripsy is a noninvasive focused ultrasound therapy that mechanically fractionates tissue to create well-defined lesions. In a previous clinical pilot trial to treat benign prostatic hyperplasia (BPH), histotripsy did not result in consi

Externí odkaz: https://doaj.org/article/fd22c9511b39495aabe7dad99459844e

Pathological Effects of Apalutamide in Lower-risk Prostate Cancer: Results From a Phase II Clinical Trial

Autor: Michael T, Schweizer, Lawrence, True, Roman, Gulati, Yibai, Zhao, William, Ellis, George, Schade, Bruce, Montgomery, Sonia, Goyal, Katie, Nega, Alexander K, Hakansson, Yang, Liu, Elai, Davicioni, Kenneth, Pienta, Peter S, Nelson, Daniel, Lin, Jonathan, Wright

Publikováno v: Journal of Urology. 209:354-363

Active surveillance is a safe and effective strategy for men with lower-risk prostate cancer who want to avoid local therapy; however, many patients on active surveillance progress to active treatment (eg, prostatectomy or radiation). We hypothesized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2919ee505785b2d14ce412f76ec73c6
https://doi.org/10.1097/ju.0000000000003038

Supplementary Figures and Methods from Cells Comprising the Prostate Cancer Microenvironment Lack Recurrent Clonal Somatic Genomic Aberrations

Autor: Peter S. Nelson, Michael Ittmann, David Rowley, Neil A. Bhowmick, Lisha Brown, Colm Morrissey, Lawrence True, Simon W. Hayward, Jason H. Bielas, Nolan G. Ericson, Omar E. Franco, Min Fang, Xiaoyu Qu, Olga Dakhova, Ilsa M. Coleman, Jeffrey J. Delrow, Ryan Basom, Daniella Bianchi-Frias

Figure S1. Copy number changes in PTEN region. Figure S2. Analysis of TP53 Aberrations. Figure S3. Allelic imbalance analysis. Figure S4. Example of HOXA9 immunohistochemistry and digital analysis output images. Figure S5. Gene expression analysis of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40a3d4381ff7f94e9fefaf2fc4366480
https://doi.org/10.1158/1541-7786.22515079.v1

Data from TWIST1-WDR5-Hottip Regulates Hoxa9 Chromatin to Facilitate Prostate Cancer Metastasis

Autor: Phuoc T. Tran, Colm Morrissey, Paula J. Hurley, Kenneth J. Pienta, Edward M. Schaeffer, Ashley E. Ross, Theodore L. DeWeese, Steven S. An, Lawrence True, Arum R. Yoon, Ghali Lemtiri-Chlieh, Kekoa Taparra, Hailun Wang, Katriana Nugent, Brian W. Simons, Belinda Nghiem, Russell D. Williams, Rajendra P. Gajula, Reem Malek

TWIST1 is a transcription factor critical for development that can promote prostate cancer metastasis. During embryonic development, TWIST1 and HOXA9 are coexpressed in mouse prostate and then silenced postnatally. Here we report that TWIST1 and HOXA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9b338c35e5aaae6fa7d8d0abd1a5fb20
https://doi.org/10.1158/0008-5472.c.6508815.v1

Comparative genomics of primary prostate cancer and paired metastases: insights from 12 molecular case studies

Autor: Joanna Cyrta, Davide Prandi, Arshi Arora, Daniel H Hovelson, Andrea Sboner, Antonio Rodriguez, Tarcisio Fedrizzi, Himisha Beltran, Dan R Robinson, Anuradha Gopalan, Lawrence True, Peter S Nelson, Brian D Robinson, Juan Miguel Mosquera, Scott A Tomlins, Ronglai Shen, Francesca Demichelis, Mark A Rubin

Publikováno v: Cyrta, Joanna; Prandi, Davide; Arora, Arshi; Hovelson, Daniel H; Sboner, Andrea; Rodriguez, Antonio; Fedrizzi, Tarcisio; Beltran, Himisha; Robinson, Dan R; Gopalan, Anurandha; True, Lawrence; Nelson, Peter S; Robinson, Brian D; Mosquera, Juan Miguel; Tomlins, Scott A; Shen, Ronglai; Demichelis, Francesca; Rubin, Mark A (2022). Comparative genomics of primary prostate cancer and paired metastases: insights from 12 molecular case studies. The journal of pathology, 257(3), pp. 274-284. Wiley 10.1002/path.5887

Primary prostate cancer (PCa) can show marked molecular heterogeneity. However, systematic analyses comparing primary PCa and matched metastases in individual patients are lacking. We aimed to address the molecular aspects of metastatic progression w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::624e2c747d5e703f313c7615751b13fb
https://doi.org/10.1002/path.5887