Zobrazeno 1 - 10
of 345
pro vyhledávání: '"Lawrence, Shapiro"'
Autor:
Laty G. Thiam, Kirsty McHugh, Aboubacar Ba, Rebecca Li, Yicheng Guo, Mariama N. Pouye, Awa Cisse, Dimitra Pipini, Fatoumata Diallo, Seynabou D. Sene, Saurabh D. Patel, Alassane Thiam, Bacary D. Sadio, Alassane Mbengue, Inés Vigan-Womas, Zizhang Sheng, Lawrence Shapiro, Simon J. Draper, Amy K. Bei
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-13 (2024)
Abstract Vaccines to the Plasmodium falciparum reticulocyte binding-like protein homologue 5 (PfRH5) target the blood-stage of the parasite life cycle. PfRH5 has the potential to trigger the production of strain-transcendent antibodies and has proven
Externí odkaz:
https://doaj.org/article/e107ccb140a3481e807421a3633b07ca
Autor:
Richard Quintana-Feliciano, Jithesh Kottur, Mi Ni, Rikhia Ghosh, Leslie Salas-Estrada, Goran Ahlsen, Olga Rechkoblit, Lawrence Shapiro, Marta Filizola, Gang Fang, Aneel K. Aggarwal
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Burkholderia cenocepacia is an opportunistic and infective bacterium containing an orphan DNA methyltransferase called M.BceJIV with roles in regulating gene expression and motility of the bacterium. M.BceJIV recognizes a GTWWAC motif (where
Externí odkaz:
https://doaj.org/article/2beb0819c5a6441cae69edcef87014d6
Autor:
Qian Wang, Ian A. Mellis, Jerren Ho, Anthony Bowen, Theresa Kowalski-Dobson, Riccardo Valdez, Phinikoula S. Katsamba, Madeline Wu, Caitlin Lee, Lawrence Shapiro, Aubree Gordon, Yicheng Guo, David D. Ho, Lihong Liu
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
The recently dominant SARS-CoV-2 Omicron JN.1 has evolved into multiple sublineages, with recurrent spike mutations R346T, F456L, and T572I, some of which exhibit growth advantages, such as KP.2 and KP.3. We investigated these mutations in JN.1, exam
Externí odkaz:
https://doaj.org/article/bc84833b02134f64ae87a0a39aa1751b
Autor:
Manxue Jia, Hanjun Zhao, Nicholas C. Morano, Hong Lu, Yin-Ming Lui, Haijuan Du, Jordan E. Becker, Kwok-Yung Yuen, David D. Ho, Peter D. Kwong, Lawrence Shapiro, Kelvin Kai-Wang To, Xueling Wu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Avian influenza A virus H7N9 causes severe human infections with >30% fatality. Currently, there is no H7N9-specific prevention or treatment for humans. Here, from a 2013 H7N9 convalescent case in Hong Kong, we isolate four hemagglutinin (HA
Externí odkaz:
https://doaj.org/article/83d250f54cd64895b1f4e8c2f5942319
Autor:
Jianliang Xu, Tongqing Zhou, Krisha McKee, Baoshan Zhang, Cuiping Liu, Alexandra F. Nazzari, Amarendra Pegu, Chen‐Hsiang Shen, Jordan E. Becker, Michael F. Bender, Payton Chan, Anita Changela, Ridhi Chaudhary, Xuejun Chen, Tal Einav, Young Do Kwon, Bob C. Lin, Mark K. Louder, Jonah S. Merriam, Nicholas C. Morano, Sijy O'Dell, Adam S. Olia, Reda Rawi, Ryan S. Roark, Tyler Stephens, I‐Ting Teng, Emily Tourtellott‐Fogt, Shuishu Wang, Eun Sung Yang, Lawrence Shapiro, Yaroslav Tsybovsky, Nicole A. Doria‐Rose, Rafael Casellas, Peter D. Kwong
Publikováno v:
Advanced Science, Vol 11, Iss 26, Pp n/a-n/a (2024)
Abstract Broadly neutralizing antibodies are proposed as therapeutic and prophylactic agents against HIV‐1, but their potency and breadth are less than optimal. This study describes the immunization of a llama with the prefusion‐stabilized HIV‐
Externí odkaz:
https://doaj.org/article/2af27b428ce0453586e0f60b99fd2446
Autor:
Adam S. Olia, Madhu Prabhakaran, Darcy R. Harris, Crystal Sao-Fong Cheung, Rebecca A. Gillespie, Jason Gorman, Abigayle Hoover, Nicholas C. Morano, Amine Ourahmane, Abhinaya Srikanth, Shuishu Wang, Weiwei Wu, Tongqing Zhou, Sarah F. Andrews, Masaru Kanekiyo, Lawrence Shapiro, Adrian B. McDermott, Peter D. Kwong
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The VH6-1 class of antibodies includes some of the broadest and most potent antibodies that neutralize influenza A virus. Here, we elicit and isolate anti-idiotype antibodies against germline versions of VH6-1 antibodies, use these to sort human leuk
Externí odkaz:
https://doaj.org/article/086e3f3dbf7c436b9fc0aa65fce2326a
Autor:
Baoshan Zhang, Jason Gorman, Young D. Kwon, Amarendra Pegu, Cara W. Chao, Tracy Liu, Mangaiarkarasi Asokan, Michael F. Bender, Tatsiana Bylund, Leland Damron, Deepika Gollapudi, Paula Lei, Yile Li, Cuiping Liu, Mark K. Louder, Krisha McKee, Adam S. Olia, Reda Rawi, Arne Schön, Shuishu Wang, Eun Sung Yang, Yongping Yang, Kevin Carlton, Nicole A. Doria-Rose, Lawrence Shapiro, Michael S. Seaman, John R. Mascola, Peter D. Kwong
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTAntibody CAP256-VRC26.25 targets the second hypervariable region (V2) at the apex of the HIV envelope (Env) trimer with extraordinary neutralization potency, although less than optimal breadth. To improve breadth, we linked the light chain of
Externí odkaz:
https://doaj.org/article/bddbe9ec6f5b4b779bcbe4b49830cab8
Autor:
Mengxiao Luo, Biao Zhou, Eswar R. Reddem, Bingjie Tang, Bohao Chen, Runhong Zhou, Hang Liu, Lihong Liu, Phinikoula S. Katsamba, Ka-Kit Au, Hiu-On Man, Kelvin Kai-Wang To, Kwok-Yung Yuen, Lawrence Shapiro, Shangyu Dang, David D. Ho, Zhiwei Chen
Publikováno v:
Emerging Microbes and Infections, Vol 12, Iss 1 (2023)
ABSTRACTIncreasing spread by SARS-CoV-2 Omicron variants challenges existing vaccines and broadly reactive neutralizing antibodies (bNAbs) against COVID-19. Here we determine the diversity, potency, breadth and structural insights of bNAbs derived fr
Externí odkaz:
https://doaj.org/article/e951ddcfe32c4425a17c8d0af05f3290
Autor:
Pengfei Wang, Ryan G. Casner, Manoj S. Nair, Jian Yu, Yicheng Guo, Maple Wang, Jasper F.-W. Chan, Gabriele Cerutti, Sho Iketani, Lihong Liu, Zizhang Sheng, Zhiwei Chen, Kwok-Yung Yuen, Peter D. Kwong, Yaoxing Huang, Lawrence Shapiro, David D. Ho
Publikováno v:
Emerging Microbes and Infections, Vol 11, Iss 1, Pp 147-157 (2022)
The repeated emergence of highly pathogenic human coronaviruses as well as their evolving variants highlight the need to develop potent and broad-spectrum antiviral therapeutics and vaccines. By screening monoclonal antibodies (mAbs) isolated from CO
Externí odkaz:
https://doaj.org/article/bd6b1f73dd464708ab57777f7213a125
Autor:
Khadidiatou Mangou, Adam J. Moore, Laty Gaye Thiam, Aboubacar Ba, Alessandra Orfanó, Ife Desamours, Duncan Ndungu Ndegwa, Justin Goodwin, Yicheng Guo, Zizhang Sheng, Saurabh D. Patel, Fatoumata Diallo, Seynabou D. Sene, Mariama N. Pouye, Awa Thioub Faye, Alassane Thiam, Vanessa Nunez, Cheikh Tidiane Diagne, Bacary Djilocalisse Sadio, Lawrence Shapiro, Ousmane Faye, Alassane Mbengue, Amy K. Bei
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract The recent stall in the global reduction of malaria deaths has made the development of a highly effective vaccine essential. A major challenge to developing an efficacious vaccine is the extensive diversity of Plasmodium falciparum antigens.
Externí odkaz:
https://doaj.org/article/828df080637f4ef3987e4b25892f785a