Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Lawrence, E Heisler"'
Autor:
Julie Livingstone, Yu-Jia Shiah, Takafumi N. Yamaguchi, Lawrence E. Heisler, Vincent Huang, Robert Lesurf, Tsumugi Gebo, Benjamin Carlin, Stefan Eng, Erik Drysdale, Jeffrey Green, Theodorus van der Kwast, Robert G. Bristow, Michael Fraser, Paul C. Boutros
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Despite the known role of telomere length in cancer, its association with genomic features remains unclear. Here, the authors integrate telomere length, genomics, transcriptomics and proteomics in localized prostate cancer and reveal links between te
Externí odkaz:
https://doaj.org/article/3a1b96dd7f314201be56b49c89bc022a
Autor:
Syed H. Zaidi, Tabitha A. Harrison, Amanda I. Phipps, Robert Steinfelder, Quang M. Trinh, Conghui Qu, Barbara L. Banbury, Peter Georgeson, Catherine S. Grasso, Marios Giannakis, Jeremy B. Adams, Elizabeth Alwers, Efrat L. Amitay, Richard T. Barfield, Sonja I. Berndt, Ivan Borozan, Hermann Brenner, Stefanie Brezina, Daniel D. Buchanan, Yin Cao, Andrew T. Chan, Jenny Chang-Claude, Charles M. Connolly, David A. Drew, Alton Brad Farris, Jane C. Figueiredo, Amy J. French, Charles S. Fuchs, Levi A. Garraway, Steve Gruber, Mark A. Guinter, Stanley R. Hamilton, Sophia Harlid, Lawrence E. Heisler, Akihisa Hidaka, John L. Hopper, Wen-Yi Huang, Jeroen R. Huyghe, Mark A. Jenkins, Paul M. Krzyzanowski, Mathieu Lemire, Yi Lin, Xuemei Luo, Elaine R. Mardis, John D. McPherson, Jessica K. Miller, Victor Moreno, Xinmeng Jasmine Mu, Reiko Nishihara, Nickolas Papadopoulos, Danielle Pasternack, Michael J. Quist, Adilya Rafikova, Emma E. G. Reid, Eve Shinbrot, Brian H. Shirts, Lincoln D. Stein, Cherie D. Teney, Lee Timms, Caroline Y. Um, Bethany Van Guelpen, Megan Van Tassel, Xiaolong Wang, David A. Wheeler, Christina K. Yung, Li Hsu, Shuji Ogino, Andrea Gsur, Polly A. Newcomb, Steven Gallinger, Michael Hoffmeister, Peter T. Campbell, Stephen N. Thibodeau, Wei Sun, Thomas J. Hudson, Ulrike Peters
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Large scale sequencing study is of paramount importance to unravel the heterogeneity of colorectal cancer. Here, the authors sequenced 205 cancer genes in more than 2000 tumours and identified additional mutated driver genes, determined that mutation
Externí odkaz:
https://doaj.org/article/a09dab8e99d844a6a6258b23214b612c
Autor:
Victor H Ferreira, Andrzej Chruscinski, Vathany Kulasingam, Trevor J Pugh, Tamara Dus, Brad Wouters, Amit Oza, Matthew Ierullo, Terrance Ku, Beata Majchrzak-Kita, Sonika T Humar, Ilona Bahinskaya, Natalia Pinzon, Jianhua Zhang, Lawrence E Heisler, Paul M Krzyzanowski, Bernard Lam, Ilinca M Lungu, Dorin Manase, Krista M Pace, Pouria Mashouri, Michael Brudno, Michael Garrels, Tony Mazzulli, Myron Cybulsky, Atul Humar, Deepali Kumar
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0247258 (2021)
Health care workers (HCWs) are at higher risk for SARS-CoV-2 infection and may play a role in transmitting the infection to vulnerable patients and members of the community. This is particularly worrisome in the context of asymptomatic infection. We
Externí odkaz:
https://doaj.org/article/296e0a64cbd94bcf97642f459073385f
Autor:
Kathleen E Houlahan, Julie Livingstone, Natalie S Fox, Natalie Kurganovs, Helen Zhu, Jocelyn Sietsma Penington, Chol-Hee Jung, Takafumi N Yamaguchi, Lawrence E Heisler, Richard Jovelin, Anthony J Costello, Bernard J Pope, Amar U Kishan, Niall M Corcoran, Robert G Bristow, Sebastian M Waszak, Joachim Weischenfeldt, Housheng H He, Rayjean J Hung, Christopher M Hovens, Paul C Boutros
Publikováno v:
JNCI: Journal of the National Cancer Institute. 115:468-472
Prostate cancer is one of the most heritable cancers. Hundreds of germline polymorphisms have been linked to prostate cancer diagnosis and prognosis. Polygenic risk scores can predict genetic risk of a prostate cancer diagnosis. Although these scores
Autor:
Julia F. Hopkins, Veronica Y. Sabelnykova, Joachim Weischenfeldt, Ronald Simon, Jennifer A. Aguiar, Rached Alkallas, Lawrence E. Heisler, Junyan Zhang, John D. Watson, Melvin L. K. Chua, Michael Fraser, Francesco Favero, Chris Lawerenz, Christoph Plass, Guido Sauter, John D. McPherson, Theodorus van der Kwast, Jan Korbel, Thorsten Schlomm, Robert G. Bristow, Paul C. Boutros
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
In prostate cancer, the role of mutations in the maternally-inherited mitochondrial genome are not well known. Here, the authors demonstrate frequent, age-dependent mitochondrial mutation in prostate cancer. Strong links between mitochondrial and nuc
Externí odkaz:
https://doaj.org/article/60e16080a49e4b41a40aef4ed8595ea3
Autor:
Renea A. Taylor, Michael Fraser, Julie Livingstone, Shadrielle Melijah G. Espiritu, Heather Thorne, Vincent Huang, Winnie Lo, Yu-Jia Shiah, Takafumi N. Yamaguchi, Ania Sliwinski, Sheri Horsburgh, Alice Meng, Lawrence E. Heisler, Nancy Yu, Fouad Yousif, Melissa Papargiris, Mitchell G. Lawrence, Lee Timms, Declan G. Murphy, Mark Frydenberg, Julia F. Hopkins, Damien Bolton, David Clouston, John D. McPherson, Theodorus van der Kwast, Paul C. Boutros, Gail P. Risbridger, Robert G. Bristow
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Men that carrierBRCA2germline mutations are at risk of developing prostate cancer. Here, the authors analyse the genomes of prostate cancer from these individuals and demonstrate increased genomic instability in comparison to sporadic prostate cancer
Externí odkaz:
https://doaj.org/article/8d920a8293a04405b9542b7f3b199b5c
Autor:
Kathleen E. Houlahan, Jiapei Yuan, Tommer Schwarz, Julie Livingstone, Natalie S. Fox, Weerachai Jaratlerdsiri, Job van Riet, Kodi Taraszka, Natalie Kurganovs, Helen Zhu, Jocelyn Sietsma Penington, Chol-Hee Jung, Takafumi N Yamaguchi, Jue Jiang, Lawrence E Heisler, Richard Jovelin, Susmita G Ramanand, Connor Bell, Edward O’Connor, Shingai B.A. Mutambirwa, Ji-Heui Seo, Anthony J. Costello, Mark M. Pomerantz, Bernard J. Pope, Noah Zaitlen, Amar U. Kishan, Niall M. Corcoran, Robert G. Bristow, Sebastian M. Waszak, Riana M.S. Bornman, Alexander Gusev, Martijn P. Lolkema, Joachim Weischenfeldt, Rayjean J. Hung, Housheng H. He, Vanessa M. Hayes, Bogdan Pasaniuc, Matthew L. Freedman, Christopher M. Hovens, Ram S. Mani, Paul C. Boutros
A person’s germline genome strongly influences their risk of developing cancer. Yet the molecular mechanisms linking the host genome to the specific somatic molecular phenotypes of individual cancers are largely unknown. We quantified the relations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36e50d2e0441546c33588312bec82162
https://doi.org/10.1101/2022.11.16.516773
https://doi.org/10.1101/2022.11.16.516773
Autor:
Tsumugi Gebo, Yu-Jia Shiah, Julie Livingstone, Lawrence E. Heisler, Michael Fraser, Robert G. Bristow, Vincent Huang, Theodorus van der Kwast, Stefan Eng, Erik Drysdale, Paul C. Boutros, Robert Lesurf, Takafumi N. Yamaguchi, Jeffrey Green, Benjamin Carlin
Publikováno v:
Nature communications, vol 12, iss 1
Nature Communications
Livingstone, J, Shiah, Y-J, Yamaguchi, T N, Heisler, L E, Huang, V, Lesurf, R, Gebo, T, Carlin, B, Eng, S, Drysdale, E, Green, J, van der Kwast, T, Bristow, R G, Fraser, M & Boutros, P C 2021, ' The telomere length landscape of prostate cancer ', Nature Communications, vol. 12, no. 1, 6893 . https://doi.org/10.1038/s41467-021-27223-6
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Livingstone, J, Shiah, Y-J, Yamaguchi, T N, Heisler, L E, Huang, V, Lesurf, R, Gebo, T, Carlin, B, Eng, S, Drysdale, E, Green, J, van der Kwast, T, Bristow, R G, Fraser, M & Boutros, P C 2021, ' The telomere length landscape of prostate cancer ', Nature Communications, vol. 12, no. 1, 6893 . https://doi.org/10.1038/s41467-021-27223-6
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Replicative immortality is a hallmark of cancer, and can be achieved through telomere lengthening and maintenance. Although the role of telomere length in cancer has been well studied, its association to genomic features is less well known. Here, we
Autor:
Quang M. Trinh, Tabitha A. Harrison, Jeremy Adams, Stephen Lee, Syed H.E. Zaidi, Emma E.G. Reid, Sophia Harlid, Barbara L. Banbury, Thomas J. Hudson, Robert S. Steinfelder, Susan Bullman, Steven Gallinger, Wei Sun, Amanda I. Phipps, Vincent Ferretti, Andrea Gsur, Li Hsu, Conghui Qu, Xuemei Luo, Yin Cao, Peter T. Campbell, John L. Hopper, Ulrike Peters, Ivan Borozan, Stephen N. Thibodeau, Jane C. Figueiredo, Lawrence E. Heisler, Jiayin Zheng, Polly A. Newcomb, Nickolas Papadopoulos, Yi Lin, Sonja I. Berndt, Daniel D. Buchanan, Caroline Y. Um, Alton B. Farris, Marios Giannakis, Shuji Ogino, Stefanie Brezina, Elaine R. Mardis, Reiko Nishihara
Publikováno v:
Cancer Epidemiol Biomarkers Prev
Background: Fusobacterium nucleatum (F. nucleatum) activates oncogenic signaling pathways and induces inflammation to promote colorectal carcinogenesis. Methods: We characterized F. nucleatum and its subspecies in colorectal tumors and examined assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d588b19713eb27529af9b95eb66e7727
https://europepmc.org/articles/PMC8755593/
https://europepmc.org/articles/PMC8755593/
Autor:
Michèle Orain, Lawrence E. Heisler, Alexander Gusev, Cindy Q. Yao, Matthew L. Freedman, Takafumi N. Yamaguchi, Ada Wong, Kathleen E. Houlahan, Vincent Huang, Ram Shankar Mani, Paul C. Boutros, Melvin L.K. Chua, Connor Bell, Thomas Kislinger, John Douglas Mcpherson, Lee Timms, Susmita G. Ramanand, Housheng Hansen He, Jiapei Yuan, Alain Bergeron, Hélène Hovington, Julie Livingstone, Mathieu Lupien, Shadrielle Melijah G. Espiritu, Yves Fradet, Mark Pomerantz, Edward P. O’Connor, Valérie Picard, Anamay Shetty, Alex Murison, Bogdan Pasaniuc, Bernard Têtu, Theodorus van der Kwast, Louis Lacombe, Yu Jia Shiah, Michelle Sam, Jeremy Johns, Alexandre Rouette, Michael Fraser, Ankit Sinha, Adrien Foucal, Robert G. Bristow, Musaddeque Ahmed
Publikováno v:
Nature Medicine. 25:1615-1626
Oncogenesis is driven by germline, environmental and stochastic factors. It is unknown how these interact to produce the molecular phenotypes of tumors. We therefore quantified the influence of germline polymorphisms on the somatic epigenome of 589 l