Výsledky vyhledávání - "Lawrence, Colwell"

Discovery of (2R)-2-(3-{3-[(4-Methoxyphenyl)carbonyl]-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl}phenoxy)butanoic acid (MK-0533): a novel selective peroxisome proliferator-activated receptor gamma modulator for the treatment of type 2 diabetes mellitus with a reduced potential to increase plasma and extracellular fluid volume

Publikováno v: Journal of medicinal chemistry. 52(13)

Peroxisome proliferator-activated receptor gamma (PPARgamma) agonists are used to treat type 2 diabetes mellitus (T2DM). Widespread use of PPARgamma agonists has been prevented due to adverse effects including weight gain, edema, and increased risk o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7561f4f77bc76db72dd54e9a82d08f45
https://pubmed.ncbi.nlm.nih.gov/19507861

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Comparison of the effects of perfusion in determining brain penetration (brain-to-plasma ratios) of small molecules in rats

Autor: Judith E, Fenyk-Melody, Xiaolan, Shen, Qianping, Peng, William, Pikounis, Lawrence, Colwell, James, Pivnichny, Lynn C, Anderson, Constantin S, Tamvakopoulos

Publikováno v: Comparative medicine. 54(4)

In the process of drug discovery, brain and plasma measurements of new chemical entities in rodents are of interest, particularly when the target receptors are in the brain. Brain-to-plasma ratios (B/P) obtained from a rodent pharmacokinetic assay ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::207a2bc8be4807b37fb88a3f0a532b62
https://pubmed.ncbi.nlm.nih.gov/15357317

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Correction to Discovery of (2R)-2-(3-{3-[(4-Methoxyphenyl)carbonyl]-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl}phenoxy)butanoic Acid (MK-0533): A Novel Selective Peroxisome Proliferator-Activated Receptor γ Modulator for the Treatment of Type 2 Diabetes Mellitus with a Reduced Potential to Increase Plasma and Extracellular Fluid Volume

Autor: John J. Acton, Taro E. Akiyama, Ching H. Chang, Lawrence Colwell, Sheryl Debenham, Thomas Doebber, Monica Einstein, Kun Liu, Margaret E. McCann, David E. Moller, Eric S. Muise, Yejun Tan, John R. Thompson, Kenny K. Wong, Margaret Wu, Libo Xu, Peter T. Meinke, Joel P. Berger, Harold B. Wood

Publikováno v: Journal of Medicinal Chemistry. 56:9368-9368

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::10b84ba8d2fc03349a39e054c1193cf0
https://doi.org/10.1021/jm401718d

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