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The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling.

Autor: Hayes, J S, Lawler, O A, Walsh, M T, Kinsella, B T

Publikováno v: Journal of Biological Chemistry; August 1999, Vol. 274 Issue: 34 p23707-18, 12p

Protein kinase A-mediated phosphorylation of serine 357 of the mouse prostacyclin receptor regulates its coupling to G(s)-, to G(i)-, and to G(q)-coupled effector signaling.

Autor: Lawler OA; Department of Biochemistry, Conway Institute of Biomolecular and Biomedical Research, Merville House, University College Dublin, Belfield, Dublin 4, Ireland., Miggin SM, Kinsella BT

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2001 Sep 07; Vol. 276 (36), pp. 33596-607. Date of Electronic Publication: 2001 Jul 06.