Cross-Validation of Metabolic Phenotypes in SARS-CoV-2 Infected Subpopulations Using Targeted Liquid Chromatography-Mass Spectrometry (LC-MS).

Autor: Whiley L; Australian National Phenome Centre, Health Futures Institute Harry Perkins Institute, Murdoch University, 5 Robin Warren Drive, Perth, WA 6150, Australia.; Centre for Computational and Systems Medicine, Health Futures Institute Harry Perkins Institute, Murdoch University, 5 Robin Warren Drive, Perth, WA 6150, Australia., Lawler NG; Australian National Phenome Centre, Health Futures Institute Harry Perkins Institute, Murdoch University, 5 Robin Warren Drive, Perth, WA 6150, Australia.; Centre for Computational and Systems Medicine, Health Futures Institute Harry Perkins Institute, Murdoch University, 5 Robin Warren Drive, Perth, WA 6150, Australia., Zeng AX; Australian National Phenome Centre, Health Futures Institute Harry Perkins Institute, Murdoch University, 5 Robin Warren Drive, Perth, WA 6150, Australia., Lee A; Australian National Phenome Centre, Health Futures Institute Harry Perkins Institute, Murdoch University, 5 Robin Warren Drive, Perth, WA 6150, Australia., Chin ST; Australian National Phenome Centre, Health Futures Institute Harry Perkins Institute, Murdoch University, 5 Robin Warren Drive, Perth, WA 6150, Australia., Bizkarguenaga M; Centro de Investigación Cooperativa en Biociencias─CIC bioGUNE, Precision Medicine and Metabolism Laboratory, Basque Research and Technology Alliance, Bizkaia Science and Technology Park, Building 800, 48160 Derio, Spain., Bruzzone C; Centro de Investigación Cooperativa en Biociencias─CIC bioGUNE, Precision Medicine and Metabolism Laboratory, Basque Research and Technology Alliance, Bizkaia Science and Technology Park, Building 800, 48160 Derio, Spain., Embade N; Centro de Investigación Cooperativa en Biociencias─CIC bioGUNE, Precision Medicine and Metabolism Laboratory, Basque Research and Technology Alliance, Bizkaia Science and Technology Park, Building 800, 48160 Derio, Spain., Wist J; Australian National Phenome Centre, Health Futures Institute Harry Perkins Institute, Murdoch University, 5 Robin Warren Drive, Perth, WA 6150, Australia.; Centre for Computational and Systems Medicine, Health Futures Institute Harry Perkins Institute, Murdoch University, 5 Robin Warren Drive, Perth, WA 6150, Australia.; Chemistry Department, Universidad del Valle, Cali 76001, Colombia., Holmes E; Australian National Phenome Centre, Health Futures Institute Harry Perkins Institute, Murdoch University, 5 Robin Warren Drive, Perth, WA 6150, Australia.; Centre for Computational and Systems Medicine, Health Futures Institute Harry Perkins Institute, Murdoch University, 5 Robin Warren Drive, Perth, WA 6150, Australia.; Department of Metabolism Digestion and Reproduction, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, U.K., Millet O; Centro de Investigación Cooperativa en Biociencias─CIC bioGUNE, Precision Medicine and Metabolism Laboratory, Basque Research and Technology Alliance, Bizkaia Science and Technology Park, Building 800, 48160 Derio, Spain., Nicholson JK; Australian National Phenome Centre, Health Futures Institute Harry Perkins Institute, Murdoch University, 5 Robin Warren Drive, Perth, WA 6150, Australia.; Centre for Computational and Systems Medicine, Health Futures Institute Harry Perkins Institute, Murdoch University, 5 Robin Warren Drive, Perth, WA 6150, Australia.; Institute of Global Health Innovation, Faculty Building South Kensington Campus, Imperial College London, London SW7 2AZ, U.K., Gray N; Australian National Phenome Centre, Health Futures Institute Harry Perkins Institute, Murdoch University, 5 Robin Warren Drive, Perth, WA 6150, Australia.; Centre for Computational and Systems Medicine, Health Futures Institute Harry Perkins Institute, Murdoch University, 5 Robin Warren Drive, Perth, WA 6150, Australia.

Publikováno v: Journal of proteome research [J Proteome Res] 2024 Apr 05; Vol. 23 (4), pp. 1313-1327. Date of Electronic Publication: 2024 Mar 14.

Integrative Molecular Structure Elucidation and Construction of an Extended Metabolic Pathway Associated with an Ancient Innate Immune Response in COVID-19 Patients.

Autor: Sala S; The Australian National Phenome Centre and Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth WA6150, Australia., Nitschke P; The Australian National Phenome Centre and Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth WA6150, Australia., Masuda R; The Australian National Phenome Centre and Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth WA6150, Australia., Gray N; The Australian National Phenome Centre and Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth WA6150, Australia., Lawler NG; The Australian National Phenome Centre and Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth WA6150, Australia., Wood JM; Ferrier Research Institute, Victoria University of Wellington, Wellington 6012, New Zealand.; The Maurice Wilkins Centre for Molecular Biodiscovef Wellington, Welry, The University of Auckland, Auckland 1010, New Zealand., Buckler JN; Ferrier Research Institute, Victoria University of Wellington, Wellington 6012, New Zealand., Berezhnoy G; Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, University Hospital Tübingen, 72074 Tübingen, Germany., Bolaños J; Chemistry Department, Universidad del Valle, Cali 76001, Colombia., Boughton BA; The Australian National Phenome Centre and Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth WA6150, Australia., Lonati C; Center for Preclinical Research, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy., Rössler T; Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, University Hospital Tübingen, 72074 Tübingen, Germany., Singh Y; Institute of Medical Genetics and Applied Genomics, University Hospital Tübingen, 72074 Tübingen, Germany., Wilson ID; Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College, Burlington Danes Building, Du Cane Road, London W12 0NN, U.K., Lodge S; The Australian National Phenome Centre and Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth WA6150, Australia., Morillon AC; The Australian National Phenome Centre and Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth WA6150, Australia., Loo RL; The Australian National Phenome Centre and Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth WA6150, Australia., Hall D; The Australian National Phenome Centre and Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth WA6150, Australia., Whiley L; The Australian National Phenome Centre and Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth WA6150, Australia., Evans GB; Ferrier Research Institute, Victoria University of Wellington, Wellington 6012, New Zealand.; The Maurice Wilkins Centre for Molecular Biodiscovef Wellington, Welry, The University of Auckland, Auckland 1010, New Zealand., Grove TL; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States., Almo SC; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States., Harris LD; Ferrier Research Institute, Victoria University of Wellington, Wellington 6012, New Zealand.; The Maurice Wilkins Centre for Molecular Biodiscovef Wellington, Welry, The University of Auckland, Auckland 1010, New Zealand., Holmes E; The Australian National Phenome Centre and Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth WA6150, Australia.; Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College, Burlington Danes Building, Du Cane Road, London W12 0NN, U.K., Merle U; Department of Internal Medicine IV, University Hospital Heidelberg, 69120 Heidelberg, Germany., Trautwein C; Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, University Hospital Tübingen, 72074 Tübingen, Germany., Nicholson JK; The Australian National Phenome Centre and Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth WA6150, Australia.; Institute of Global Health Innovation, Faculty of Medicine, Imperial College London, Level 1, Faculty Building, South Kensington Campus, London SW7 2NA, U.K., Wist J; The Australian National Phenome Centre and Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth WA6150, Australia.; Chemistry Department, Universidad del Valle, Cali 76001, Colombia.; Faculty of Medicine, Department of Metabolism, Digestion and Reproduction, Division of Digestive Diseases at Imperial College, London SW7 2AZ, U.K.

Publikováno v: Journal of proteome research [J Proteome Res] 2024 Mar 01; Vol. 23 (3), pp. 956-970. Date of Electronic Publication: 2024 Feb 04.

Integrative Plasma Metabolic and Lipidomic Modelling of SARS-CoV-2 Infection in Relation to Clinical Severity and Early Mortality Prediction.

Autor: Lodge S; Australian National Phenome Center, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA 6150, Australia.; Center for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA 6150, Australia., Lawler NG; Australian National Phenome Center, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA 6150, Australia.; Center for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA 6150, Australia., Gray N; Australian National Phenome Center, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA 6150, Australia.; Center for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA 6150, Australia., Masuda R; Australian National Phenome Center, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA 6150, Australia., Nitschke P; Australian National Phenome Center, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA 6150, Australia., Whiley L; Australian National Phenome Center, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA 6150, Australia.; Center for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA 6150, Australia., Bong SH; Australian National Phenome Center, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA 6150, Australia., Yeap BB; Medical School, University of Western Australia, Perth, WA 6150, Australia.; Department of Endocrinology and Diabetes, Fiona Stanley Hospital, Perth, WA 6150, Australia., Dwivedi G; Medical School, University of Western Australia, Perth, WA 6150, Australia.; Department of Cardiology, Fiona Stanley Hospital, Perth, WA 6150, Australia., Spraul M; Bruker Biospin GmbH, 76287 Rheinstetten, Germany., Schaefer H; Bruker Biospin GmbH, 76287 Rheinstetten, Germany., Gil-Redondo R; Precision Medicine and Metabolism Laboratory, CIC bioGUNE, Parque Tecnológico de Bizkaia, Bld. 800, 48160 Derio, Spain., Embade N; Precision Medicine and Metabolism Laboratory, CIC bioGUNE, Parque Tecnológico de Bizkaia, Bld. 800, 48160 Derio, Spain., Millet O; Precision Medicine and Metabolism Laboratory, CIC bioGUNE, Parque Tecnológico de Bizkaia, Bld. 800, 48160 Derio, Spain., Holmes E; Australian National Phenome Center, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA 6150, Australia.; Center for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA 6150, Australia.; Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK., Wist J; Australian National Phenome Center, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA 6150, Australia.; Center for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA 6150, Australia.; Chemistry Department, Universidad del Valle, Cali 76001, Colombia., Nicholson JK; Australian National Phenome Center, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA 6150, Australia.; Center for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA 6150, Australia.; Institute of Global Health Innovation, Faculty of Medicine, Imperial College London, Faculty Building, South Kensington Campus, London SW7 2NA, UK.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2023 Jul 18; Vol. 24 (14). Date of Electronic Publication: 2023 Jul 18.

Comprehensive Lipidomic Workflow for Multicohort Population Phenotyping Using Stable Isotope Dilution Targeted Liquid Chromatography-Mass Spectrometry.

Autor: Ryan MJ; Australian National Phenome Centre, Health Futures Institute, Harry Perkins Institute, Murdoch University, 5 Robin Warren Drive, Perth, Western Australia 6150, Australia.; Centre for Computational and Systems Medicine, Health Futures Institute, Harry Perkins Institute, Murdoch University, 5 Robin Warren Drive, Perth, Western Australia 6150, Australia., Grant-St James A; Australian National Phenome Centre, Health Futures Institute, Harry Perkins Institute, Murdoch University, 5 Robin Warren Drive, Perth, Western Australia 6150, Australia.; Centre for Computational and Systems Medicine, Health Futures Institute, Harry Perkins Institute, Murdoch University, 5 Robin Warren Drive, Perth, Western Australia 6150, Australia., Lawler NG; Australian National Phenome Centre, Health Futures Institute, Harry Perkins Institute, Murdoch University, 5 Robin Warren Drive, Perth, Western Australia 6150, Australia.; Centre for Computational and Systems Medicine, Health Futures Institute, Harry Perkins Institute, Murdoch University, 5 Robin Warren Drive, Perth, Western Australia 6150, Australia., Fear MW; Burn Injury Research Unit, University of Western Australia, Perth, Western Australia 6009, Australia.; Fiona Wood Foundation, Perth, Western Australia 6150, Australia., Raby E; Department of Microbiology, PathWest Laboratory Medicine, Perth, Western Australia 6009, Australia.; Department of Infectious Diseases, Fiona Stanley Hospital, Perth, Western Australia 6150, Australia., Wood FM; Burn Injury Research Unit, University of Western Australia, Perth, Western Australia 6009, Australia.; WA Department of Health, Burns Service WA, Perth, Western Australia 6009, Australia.; Fiona Wood Foundation, Perth, Western Australia 6150, Australia., Maker GL; Australian National Phenome Centre, Health Futures Institute, Harry Perkins Institute, Murdoch University, 5 Robin Warren Drive, Perth, Western Australia 6150, Australia., Wist J; Australian National Phenome Centre, Health Futures Institute, Harry Perkins Institute, Murdoch University, 5 Robin Warren Drive, Perth, Western Australia 6150, Australia.; Centre for Computational and Systems Medicine, Health Futures Institute, Harry Perkins Institute, Murdoch University, 5 Robin Warren Drive, Perth, Western Australia 6150, Australia., Holmes E; Australian National Phenome Centre, Health Futures Institute, Harry Perkins Institute, Murdoch University, 5 Robin Warren Drive, Perth, Western Australia 6150, Australia.; Centre for Computational and Systems Medicine, Health Futures Institute, Harry Perkins Institute, Murdoch University, 5 Robin Warren Drive, Perth, Western Australia 6150, Australia., Nicholson JK; Australian National Phenome Centre, Health Futures Institute, Harry Perkins Institute, Murdoch University, 5 Robin Warren Drive, Perth, Western Australia 6150, Australia.; Centre for Computational and Systems Medicine, Health Futures Institute, Harry Perkins Institute, Murdoch University, 5 Robin Warren Drive, Perth, Western Australia 6150, Australia., Whiley L; Australian National Phenome Centre, Health Futures Institute, Harry Perkins Institute, Murdoch University, 5 Robin Warren Drive, Perth, Western Australia 6150, Australia.; Centre for Computational and Systems Medicine, Health Futures Institute, Harry Perkins Institute, Murdoch University, 5 Robin Warren Drive, Perth, Western Australia 6150, Australia.; Perron Institute for Neurological and Translational Science, Nedlands, Western Australia 6009, Australia., Gray N; Australian National Phenome Centre, Health Futures Institute, Harry Perkins Institute, Murdoch University, 5 Robin Warren Drive, Perth, Western Australia 6150, Australia.; Centre for Computational and Systems Medicine, Health Futures Institute, Harry Perkins Institute, Murdoch University, 5 Robin Warren Drive, Perth, Western Australia 6150, Australia.

Publikováno v: Journal of proteome research [J Proteome Res] 2023 May 05; Vol. 22 (5), pp. 1419-1433. Date of Electronic Publication: 2023 Feb 24.

A patient-centric modeling framework captures recovery from SARS-CoV-2 infection.

Autor: Ruffieux H; MRC Biostatistics Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK. helene.ruffieux@mrc-bsu.cam.ac.uk., Hanson AL; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Lodge S; Australian National Phenome Centre, Health Futures Institute, Murdoch University, Perth, Western Australia, Australia.; Center for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Perth, Western Australia, Australia., Lawler NG; Australian National Phenome Centre, Health Futures Institute, Murdoch University, Perth, Western Australia, Australia.; Center for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Perth, Western Australia, Australia., Whiley L; Australian National Phenome Centre, Health Futures Institute, Murdoch University, Perth, Western Australia, Australia.; Center for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Perth, Western Australia, Australia.; Perron Institute for Neurological and Translational Science, Nedlands, Western Australia, Australia., Gray N; Australian National Phenome Centre, Health Futures Institute, Murdoch University, Perth, Western Australia, Australia.; Center for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Perth, Western Australia, Australia., Nolan TH; MRC Biostatistics Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK., Bergamaschi L; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Mescia F; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Turner L; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., de Sa A; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Pelly VS; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Kotagiri P; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Kingston N; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.; NIHR BioResource, Cambridge University Hospitals NHS Foundation, Cambridge Biomedical Campus, Cambridge, UK., Bradley JR; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.; NIHR BioResource, Cambridge University Hospitals NHS Foundation, Cambridge Biomedical Campus, Cambridge, UK., Holmes E; Australian National Phenome Centre, Health Futures Institute, Murdoch University, Perth, Western Australia, Australia.; Center for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Perth, Western Australia, Australia.; Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK., Wist J; Australian National Phenome Centre, Health Futures Institute, Murdoch University, Perth, Western Australia, Australia.; Center for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Perth, Western Australia, Australia.; Chemistry Department, Universidad del Valle, Cali, Colombia., Nicholson JK; Australian National Phenome Centre, Health Futures Institute, Murdoch University, Perth, Western Australia, Australia.; Center for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Perth, Western Australia, Australia.; Institute of Global Health Innovation, Imperial College London, London, UK., Lyons PA; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Smith KGC; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Richardson S; MRC Biostatistics Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK., Bantug GR; Department of Biomedicine, University and University Hospital Basel, Basel, Switzerland.; Botnar Research Centre for Child Health (BRCCH) University Basel & ETH Zurich, Basel, Switzerland., Hess C; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK. ch818@cam.ac.uk.; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK. ch818@cam.ac.uk.; Department of Biomedicine, University and University Hospital Basel, Basel, Switzerland. ch818@cam.ac.uk.; Botnar Research Centre for Child Health (BRCCH) University Basel & ETH Zurich, Basel, Switzerland. ch818@cam.ac.uk.

Publikováno v: Nature immunology [Nat Immunol] 2023 Feb; Vol. 24 (2), pp. 349-358. Date of Electronic Publication: 2023 Jan 30.