Empagliflozin reduces oxidative stress through inhibition of the novel inflammation/NHE/[Na+]c/ROS-pathway in human endothelial cells

Autor: Laween Uthman, Xiaoling Li, Antonius Baartscheer, Cees A. Schumacher, Patricia Baumgart, Jeroen Hermanides, Benedikt Preckel, Markus W. Hollmann, Ruben Coronel, Coert J. Zuurbier, Nina C. Weber

Publikováno v: Biomedicine & Pharmacotherapy, Vol 146, Iss , Pp 112515- (2022)

Inflammation causing oxidative stress in endothelial cells contributes to heart failure development. Sodium/glucose cotransporter 2 inhibitors (SGLT2i’s) were shown to reduce heart failure hospitalization and oxidative stress. However, how inflamma

Externí odkaz: https://doaj.org/article/714ef2cb2d7f40598704c5380f100e1b

Empagliflozin Decreases Lactate Generation in an NHE-1 Dependent Fashion and Increases α-Ketoglutarate Synthesis From Palmitate in Type II Diabetic Mouse Hearts

Autor: Hong Zhang, Laween Uthman, Diane Bakker, Sahinda Sari, Sha Chen, Markus W. Hollmann, Ruben Coronel, Nina C. Weber, Sander M. Houten, Michel van Weeghel, Coert J. Zuurbier

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 7 (2020)

Aims/hypothesis: Changes in cardiac metabolism and ion homeostasis precede and drive cardiac remodeling and heart failure development. We previously demonstrated that sodium/glucose cotransporter 2 inhibitors (SGLT2i's) have direct cardiac effects on

Externí odkaz: https://doaj.org/article/908a771a40ff4285a5ac4f1f00cafc9b

Imatinib attenuates reperfusion injury in a rat model of acute myocardial infarction

Autor: Lara S. F. Konijnenberg, Tom T. J. Luiken, Andor Veltien, Laween Uthman, Carolien T. A. Kuster, Laura Rodwell, Guus A. de Waard, Mariska Kea-te Lindert, Anat Akiva, Dick H. J. Thijssen, Robin Nijveldt, Niels van Royen

Publikováno v: Basic Research in Cardiology, 118, 1
Basic Research in Cardiology, 118
Konijnenberg, L S F, Luiken, T T J, Veltien, A, Uthman, L, Kuster, C T A, Rodwell, L, de Waard, G A, Kea-te Lindert, M, Akiva, A, Thijssen, D H J, Nijveldt, R & van Royen, N 2023, ' Imatinib attenuates reperfusion injury in a rat model of acute myocardial infarction ', Basic Research in Cardiology, vol. 118, no. 1, 2 . https://doi.org/10.1007/s00395-022-00974-z
Basic Research in Cardiology, 118(1):2. D. Steinkopff-Verlag

Following an acute myocardial infarction, reperfusion of an occluded coronary artery is often accompanied by microvascular injury, leading to worse long-term prognosis. Experimental studies have revealed the potential of tyrosine-kinase inhibitor ima

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdda5cdadd181a0e86fdf0620ec181d9
https://doi.org/10.1007/s00395-022-00974-z

Exercise-induced release of cardiac troponin is attenuated with repeated bouts of exercise: impact of cardiovascular disease and risk factors

Autor: Yasina B. Somani, Laween Uthman, Vincent L. Aengevaeren, Laura Rodwell, Gregory Y. H. Lip, Maria T. E. Hopman, Niels Van Royen, Thijs M. H. Eijsvogels, Dick H. J. Thijssen

Publikováno v: American Journal of Physiology : Heart and Circulatory Physiology, 324, H519-H524
American Journal of Physiology. Heart and Circulatory Physiology, 324(4), H519-H524. American Physiological Society
American Journal of Physiology : Heart and Circulatory Physiology, 324, 4, pp. H519-H524

Contains fulltext : 291504.pdf (Publisher’s version ) (Closed access) Prolonged exercise can induce cardiac troponin release. As single bouts of exercise may protect against cardiac injury, we explored the hypothesis that the magnitude of exercise-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4a9c18d67359126e6867b6e1e1f899a
http://hdl.handle.net/2066/291504

Novel Anti-inflammatory Effects of Canagliflozin Involving Hexokinase II in Lipopolysaccharide-Stimulated Human Coronary Artery Endothelial Cells

Autor: Markus W. Hollmann, Benedikt Preckel, Jens Kessler, Gregor Römer, Nina C. Weber, Marleen Boomsma, Coert J. Zuurbier, Laween Uthman, Jeroen Hermanides, Marius C Kuschma

Publikováno v: Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy, 35(6). Kluwer Academic Publishers
Cardiovascular Drugs and Therapy

Purpose Vascular inflammation and disturbed metabolism are observed in heart failure and type 2 diabetes mellitus. Glycolytic enzyme hexokinase II (HKII) is upregulated by inflammation. We hypothesized that SGLT2 inhibitors Canagliflozin (Cana), Empa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b77ac0c00fae9fd5d5b748a0ff50a42d
https://pure.amc.nl/en/publications/novel-antiinflammatory-effects-of-canagliflozin-involving-hexokinase-ii-in-lipopolysaccharidestimulated-human-coronary-artery-endothelial-cells(d133d916-3629-4d1b-bcb7-1d87e2219b28).html