Mammary Tumor Organoid Culture in Non-Adhesive Alginate for Luminal Mechanics and High-Throughput Drug Screening

Autor: Fang, G, Lu, H, Rodriguez de la Fuente, L, Law, AMK, Lin, G, Jin, D, Gallego-Ortega, D

Mammary tumor organoids have become a promising in vitro model for drug screening and personalized medicine. However, the dependency on the basement membrane extract (BME) as the growth matrices limits their comprehensive application. In this work, m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______363::5b2a5a8dcedb78968c5491b30d86e2a7
https://hdl.handle.net/10453/154349

MCL-1 antagonism enhances the anti-invasive effects of dasatinib in pancreatic adenocarcinoma

Autor: Castillo L, Young AIJ, Mawson A, Schafranek P, Steinmann AM, Nessem D, Parkin A, Johns A, Chou A, Law AMK, Lucas MC, Murphy KJ, Deng N, Gallego-Ortega D, Caldon CE, Australian Pancreatic Cancer Genome Initiative (APGI), Timpson P, Pajic M, Ormandy CJ, Oakes SR

Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies. It is phenotypically heterogeneous with a highly unstable genome and provides few common therapeutic targets. We found that MCL1, Cofilin1 (CFL1) and SRC mRNA were hig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______363::6c1e7aebf93256bc3fd0ad16986ca325
https://hdl.handle.net/10453/144833

Andy's Algorithms: new automated digital image analysis pipelines for FIJI

Autor: Law, AMK, Yin, JXM, Castillo, L, Young, AIJ, Piggin, C, Rogers, S, Caldon, CE, Burgess, A, Millar, EKA, O'Toole, SA, Gallego-Ortega, D, Ormandy, CJ, Oakes, SR

Quantification of cellular antigens and their interactions via antibody-based detection methods are widely used in scientific research. Accurate high-throughput quantitation of these assays using general image analysis software can be time consuming

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______363::185e9d7a6ec496429a842f53776822a3
https://hdl.handle.net/10453/156216

Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis.

Autor: Papanicolaou M; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Sydney, NSW, Australia.; School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia.; Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia., Parker AL; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Sydney, NSW, Australia.; Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.; School of Clinical Medicine, St Vincent's Healthcare Clinical Campus, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia., Yam M; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Sydney, NSW, Australia.; Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia., Filipe EC; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Sydney, NSW, Australia.; Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.; School of Clinical Medicine, St Vincent's Healthcare Clinical Campus, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia., Wu SZ; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Sydney, NSW, Australia.; Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.; School of Clinical Medicine, St Vincent's Healthcare Clinical Campus, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia., Chitty JL; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Sydney, NSW, Australia.; Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.; School of Clinical Medicine, St Vincent's Healthcare Clinical Campus, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia., Wyllie K; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Sydney, NSW, Australia.; Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia., Tran E; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Sydney, NSW, Australia.; Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia., Mok E; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Sydney, NSW, Australia.; Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia., Nadalini A; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Sydney, NSW, Australia.; Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia., Skhinas JN; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Sydney, NSW, Australia.; Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia., Lucas MC; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Sydney, NSW, Australia., Herrmann D; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Sydney, NSW, Australia.; Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.; School of Clinical Medicine, St Vincent's Healthcare Clinical Campus, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia., Nobis M; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Sydney, NSW, Australia.; Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.; School of Clinical Medicine, St Vincent's Healthcare Clinical Campus, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia., Pereira BA; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Sydney, NSW, Australia.; Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.; School of Clinical Medicine, St Vincent's Healthcare Clinical Campus, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia., Law AMK; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Sydney, NSW, Australia., Castillo L; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Sydney, NSW, Australia., Murphy KJ; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Sydney, NSW, Australia.; Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.; School of Clinical Medicine, St Vincent's Healthcare Clinical Campus, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia., Zaratzian A; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Sydney, NSW, Australia., Hastings JF; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Sydney, NSW, Australia., Croucher DR; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Sydney, NSW, Australia.; School of Clinical Medicine, St Vincent's Healthcare Clinical Campus, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia., Lim E; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Sydney, NSW, Australia.; School of Clinical Medicine, St Vincent's Healthcare Clinical Campus, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia., Oliver BG; School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia.; Woolcock Institute of Medical Research, Respiratory Cellular and Molecular Biology, The University of Sydney, Sydney, NSW, Australia., Mora FV; Cancer Epigenetic Biology and Therapeutics, Personalised Medicine, Children's Cancer Institute, Sydney, NSW, 2031, Australia.; School of Women's and Children's Health, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia., Parker BL; Metabolic Systems Biology Laboratory, Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Sydney, NSW, Australia., Gallego-Ortega D; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Sydney, NSW, Australia.; School of Clinical Medicine, St Vincent's Healthcare Clinical Campus, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia.; School of Biomedical Engineering, Faculty of Engineering and Information Technology, University of Technology Sydney, Sydney, NSW, Australia., Swarbrick A; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Sydney, NSW, Australia.; Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.; School of Clinical Medicine, St Vincent's Healthcare Clinical Campus, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia., O'Toole S; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Sydney, NSW, Australia.; School of Clinical Medicine, St Vincent's Healthcare Clinical Campus, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia.; Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital and NSW Health Pathology, Sydney, NSW, Australia., Timpson P; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Sydney, NSW, Australia. p.timpson@garvan.org.au.; Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia. p.timpson@garvan.org.au.; School of Clinical Medicine, St Vincent's Healthcare Clinical Campus, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia. p.timpson@garvan.org.au., Cox TR; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Sydney, NSW, Australia. t.cox@garvan.org.au.; Cancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia. t.cox@garvan.org.au.; School of Clinical Medicine, St Vincent's Healthcare Clinical Campus, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia. t.cox@garvan.org.au.

Publikováno v: Nature communications [Nat Commun] 2022 Aug 06; Vol. 13 (1), pp. 4587. Date of Electronic Publication: 2022 Aug 06.

Activation of the viral sensor oligoadenylate synthetase 2 (Oas2) prevents pregnancy-driven mammary cancer metastases.

Autor: Ho WJ; Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst Sydney, NSW, 2010, Australia.; St. Vincent's Clinical School, St. Vincent's Hospital, UNSW Sydney, Kensington, NSW, Australia., Law AMK; Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst Sydney, NSW, 2010, Australia.; St. Vincent's Clinical School, St. Vincent's Hospital, UNSW Sydney, Kensington, NSW, Australia., Masle-Farquhar E; Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst Sydney, NSW, 2010, Australia.; St. Vincent's Clinical School, St. Vincent's Hospital, UNSW Sydney, Kensington, NSW, Australia., Castillo LE; Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst Sydney, NSW, 2010, Australia.; St. Vincent's Clinical School, St. Vincent's Hospital, UNSW Sydney, Kensington, NSW, Australia., Mawson A; Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst Sydney, NSW, 2010, Australia.; St. Vincent's Clinical School, St. Vincent's Hospital, UNSW Sydney, Kensington, NSW, Australia., O'Bryan MK; The School of BioSciences and Bio21 Institute, Faculty of Science, The University of Melbourne, Parkville, Melbourne, VIC, 3010, Australia., Goodnow CC; Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst Sydney, NSW, 2010, Australia.; Cellular Genomics Futures Institute, UNSW Sydney, Kensington, NSW, Australia., Gallego-Ortega D; Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst Sydney, NSW, 2010, Australia.; St. Vincent's Clinical School, St. Vincent's Hospital, UNSW Sydney, Kensington, NSW, Australia.; School of Biomedical Engineering, Faculty of Engineering and Information Technology, University of Technology Sydney, 81 Broadway, Ultimo Sydney, NSW, 2007, Australia., Oakes SR; Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst Sydney, NSW, 2010, Australia.; St. Vincent's Clinical School, St. Vincent's Hospital, UNSW Sydney, Kensington, NSW, Australia.; National Breast Cancer Foundation Level 7, 50 Margaret Street, Sydney, NSW, 2001, Australia., Ormandy CJ; Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst Sydney, NSW, 2010, Australia. c.ormandy@garvan.org.au.; St. Vincent's Clinical School, St. Vincent's Hospital, UNSW Sydney, Kensington, NSW, Australia. c.ormandy@garvan.org.au.

Publikováno v: Breast cancer research : BCR [Breast Cancer Res] 2022 May 03; Vol. 24 (1), pp. 31. Date of Electronic Publication: 2022 May 03.