Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Lavoisier Ramos-Espiritu"'
Autor:
Christopher S. Krumm, Renée S. Landzberg, Lavoisier Ramos-Espiritu, Carolina Adura, Xu Liu, Mariana Acuna, Yang Xie, Xu Xu, Matthew C. Tillman, Yingxia Li, J. Fraser Glickman, Eric A. Ortlund, John D. Ginn, David E. Cohen
Publikováno v:
Molecular Metabolism, Vol 78, Iss , Pp 101832- (2023)
Objective: Thioesterase superfamily member 1 (Them1) is a long chain acyl-CoA thioesterase comprising two N-terminal HotDog fold enzymatic domains linked to a C-terminal lipid-sensing steroidogenic acute regulatory transfer-related (START) domain, wh
Externí odkaz:
https://doaj.org/article/8de5909740c140df964ea243b24a5e5d
Autor:
Lodoe Lama, Carolina Adura, Wei Xie, Daisuke Tomita, Taku Kamei, Vitaly Kuryavyi, Tasos Gogakos, Joshua I. Steinberg, Michael Miller, Lavoisier Ramos-Espiritu, Yasutomi Asano, Shogo Hashizume, Jumpei Aida, Toshihiro Imaeda, Rei Okamoto, Andy J. Jennings, Mayako Michino, Takanobu Kuroita, Andrew Stamford, Pu Gao, Peter Meinke, J. Fraser Glickman, Dinshaw J. Patel, Thomas Tuschl
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Cyclic GMP-AMP synthase (cGAS) is involved in the modulation of inflammatory responses. Here, the authors present small-molecule inhibitors of human cGAS, characterize their interaction with the protein, and show that the compounds are active in inte
Externí odkaz:
https://doaj.org/article/6f06ae155ca2436dab39b0d693daf384
Autor:
Sanford M. Simon, Michael V. Ortiz, Michael S. Torbenson, Philip Coffino, Anthony Letai, Charles M. Rice, Michael P. LaQuaglia, Hans-Guido Wendel, Tomoaki Kato, Faith Tierney, Rory L. Smoot, Mark J. Truty, Jennifer L. Leiting, Martin Hertl, Erik Schadde, Jessica Ellison, Barbara A. Lyons, J. Fraser Glickman, Ethan M. Weinberg, James A. Saltsman, William J. Hammond, Benjamin A. Farber, Arlene M. Hurley, Koen O.A. Vercauteren, Mohammad Kabbani, Eleftherios Michailidis, Solomon Levin, Bassem Shebl, Nicole J.C. Narayan, Ruisi Wang, Ype P. de Jong, Patrick D. Bhola, Denise Ng, Lavoisier Ramos-Espiritu, David Requena, Gadi Lalazar
To repurpose therapeutics for fibrolamellar carcinoma (FLC), we developed and validated patient-derived xenografts (PDX) from surgical resections. Most agents used clinically and inhibitors of oncogenes overexpressed in FLC showed little efficacy on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b2e6eadd89b35c3fbc11103d986522f
https://doi.org/10.1158/2159-8290.c.6549037.v1
https://doi.org/10.1158/2159-8290.c.6549037.v1
Autor:
Sanford M. Simon, Michael V. Ortiz, Michael S. Torbenson, Philip Coffino, Anthony Letai, Charles M. Rice, Michael P. LaQuaglia, Hans-Guido Wendel, Tomoaki Kato, Faith Tierney, Rory L. Smoot, Mark J. Truty, Jennifer L. Leiting, Martin Hertl, Erik Schadde, Jessica Ellison, Barbara A. Lyons, J. Fraser Glickman, Ethan M. Weinberg, James A. Saltsman, William J. Hammond, Benjamin A. Farber, Arlene M. Hurley, Koen O.A. Vercauteren, Mohammad Kabbani, Eleftherios Michailidis, Solomon Levin, Bassem Shebl, Nicole J.C. Narayan, Ruisi Wang, Ype P. de Jong, Patrick D. Bhola, Denise Ng, Lavoisier Ramos-Espiritu, David Requena, Gadi Lalazar
Supplementary Figure 1 - 6 and Supplementary Tables 1, 2, and 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b902995a0b627ef4461c460e313fed
https://doi.org/10.1158/2159-8290.22539256
https://doi.org/10.1158/2159-8290.22539256
Autor:
Sanford M. Simon, Michael V. Ortiz, Michael S. Torbenson, Philip Coffino, Anthony Letai, Charles M. Rice, Michael P. LaQuaglia, Hans-Guido Wendel, Tomoaki Kato, Faith Tierney, Rory L. Smoot, Mark J. Truty, Jennifer L. Leiting, Martin Hertl, Erik Schadde, Jessica Ellison, Barbara A. Lyons, J. Fraser Glickman, Ethan M. Weinberg, James A. Saltsman, William J. Hammond, Benjamin A. Farber, Arlene M. Hurley, Koen O.A. Vercauteren, Mohammad Kabbani, Eleftherios Michailidis, Solomon Levin, Bassem Shebl, Nicole J.C. Narayan, Ruisi Wang, Ype P. de Jong, Patrick D. Bhola, Denise Ng, Lavoisier Ramos-Espiritu, David Requena, Gadi Lalazar
List of compounds in the primary screen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca221efe677664568327262bb0935e7f
https://doi.org/10.1158/2159-8290.22539253
https://doi.org/10.1158/2159-8290.22539253
Autor:
Christopher S. Krumm, Renee S. Landzberg, Lavoisier Ramos-Espiritu, Carolina Adura, Xu Liu, Mariana Acuna, Yang Xie, Xu Xu, Matthew C. Tillman, Yingxia Li, J. Fraser Glickman, Eric Ortlund, John D. Ginn, David E. Cohen
Thioesterase superfamily member 1 (Them1; synonyms Acyl-CoA thioesterase 11 (Acot11) and steroidogenic acute regulatory protein-related lipid transfer (START) domain 14 (StarD14) is a long chain acyl-CoA thioesterase comprising two N-terminal hot-dog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54729709ca6c0a06c32c9d799f040f37
https://doi.org/10.1101/2022.10.15.512369
https://doi.org/10.1101/2022.10.15.512369
Autor:
Ethan M. Weinberg, Michael Torbenson, Nicole J.C. Narayan, William J. Hammond, Gadi Lalazar, Ruisi Wang, Solomon Levin, Denise Ng, Michael P. LaQuaglia, Lavoisier Ramos-Espiritu, David Requena, J. Fraser Glickman, Barbara A. Lyons, Rory L. Smoot, Charles M. Rice, Eleftherios Michailidis, Jessica Ellison, Benjamin A. Farber, Erik Schadde, Hans-Guido Wendel, Koen Vercauteren, Faith Tierney, Arlene Hurley, Patrick Bhola, Mark J. Truty, Tomoaki Kato, Martin Hertl, Philip Coffino, Mohammad Kabbani, Anthony Letai, Jennifer L. Leiting, Ype P. de Jong, Bassem Shebl, Sanford M. Simon, James A. Saltsman, Michael V. Ortiz
Publikováno v:
Cancer Discov
To repurpose therapeutics for fibrolamellar carcinoma (FLC), we developed and validated patient-derived xenografts (PDX) from surgical resections. Most agents used clinically and inhibitors of oncogenes overexpressed in FLC showed little efficacy on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::966cf4d6404337fbeea04a8fa44d7bd2
https://doi.org/10.1158/2159-8290.cd-20-0872
https://doi.org/10.1158/2159-8290.cd-20-0872
Autor:
Nicole J.C. Narayan, David Requena, Gadi Lalazar, Lavoisier Ramos-Espiritu, Denise Ng, Solomon Levin, Bassem Shebl, Ruisi Wang, William J. Hammond, James A. Saltsman, Helmuth Gehart, Michael S. Torbenson, Hans Clevers, Michael P. LaQuaglia, Sanford M. Simon
Publikováno v:
Stem Cell Reports, 17(8), 1874-1888. Cell Press
Stem Cell Reports, 17 (8)
Stem Cell Reports, 17 (8)
Fibrolamellar carcinoma (FLC) is a rare, often lethal, liver cancer affecting adolescents and young adults, for which there are no approved therapeutics. The development of therapeutics is hampered by a lack of in vitro models. Organoids have shown u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37304e3e13386ba989814f730535fbd0
Autor:
J. Fraser Glickman, Matthew C. Tillman, Eric A. Ortlund, Carolina Adura, Renée Landzberg, David E. Cohen, Christopher Steven Krumm, Lavoisier Ramos-Espiritu
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::896f0e06bb5830c2e97fbe2bde413478
https://doi.org/10.1096/fasebj.2021.35.s1.04142
https://doi.org/10.1096/fasebj.2021.35.s1.04142
Publikováno v:
The Journal of General Physiology
Lysosomes are the main degradative compartment in cells and require an acidic luminal environment for correct function. Rahman et al. show that soluble adenylyl cyclase is required for localization of the V-ATPase proton pump to lysosomes and therefo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb95d215a183e6a4172242d00dc50faf
https://doi.org/10.1085/jgp.201611606
https://doi.org/10.1085/jgp.201611606