Transition Readiness Assessment for Sickle Cell Patients: A Quality Improvement Project.

Autor: Porte, Jerlym S., Carroll, Yvonne M., Anderson, Sheila, Lavoie Jr., Paul T., Hamilton, Latacha, Johnson, Margery, Hankins, Jane S.

Publikováno v: Journal of Clinical Outcomes Management; 2014 Jun, Vol. 21 Issue 6, p263-269, 7p

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Evaluation of resazurin phenoxazine dye as a highly sensitive cell viability potency assay for natural killer cell-derived extracellular vesicle-based cancer biotherapeutics.

Autor: St-Denis-Bissonnette F; Biologic and Radiopharmaceutical Drugs Directorate Health Canada Ottawa Canada.; Department of Biochemistry, Microbiology and Immunology University of Ottawa Ottawa Canada., Qiu S; Biologic and Radiopharmaceutical Drugs Directorate Health Canada Ottawa Canada., Cummings SE; Biologic and Radiopharmaceutical Drugs Directorate Health Canada Ottawa Canada., Kirkby M; Biologic and Radiopharmaceutical Drugs Directorate Health Canada Ottawa Canada.; Department of Biochemistry, Microbiology and Immunology University of Ottawa Ottawa Canada., Haile Y; Biologic and Radiopharmaceutical Drugs Directorate Health Canada Ottawa Canada.; Department of Neuroscience Carleton University Ottawa Canada., Wassmer S; Biologic and Radiopharmaceutical Drugs Directorate Health Canada Ottawa Canada., Muradia G; Biologic and Radiopharmaceutical Drugs Directorate Health Canada Ottawa Canada., Mehic J; Biologic and Radiopharmaceutical Drugs Directorate Health Canada Ottawa Canada., Stalker A; Biologic and Radiopharmaceutical Drugs Directorate Health Canada Ottawa Canada., Shrestha A; Department of Biochemistry, Microbiology and Immunology University of Ottawa Ottawa Canada., Ardolino M; Department of Biochemistry, Microbiology and Immunology University of Ottawa Ottawa Canada.; Centre for Infection, Immunity and Inflammation University of Ottawa Ottawa Canada.; Cancer Therapeutics Program Ottawa Hospital Research Institute Ottawa Canada., Lee SH; Department of Biochemistry, Microbiology and Immunology University of Ottawa Ottawa Canada.; Centre for Infection, Immunity and Inflammation University of Ottawa Ottawa Canada., Burger D; Kidney Research Centre Ottawa Hospital Research Institute Ottawa Canada.; Department of Cellular and Molecular Medicine University of Ottawa Ottawa Canada., Wang L; Department of Biochemistry, Microbiology and Immunology University of Ottawa Ottawa Canada.; Centre for Infection, Immunity and Inflammation University of Ottawa Ottawa Canada.; Regenerative Medicine Program Ottawa Hospital Research Institute Ottawa Canada., Lavoie JR; Biologic and Radiopharmaceutical Drugs Directorate Health Canada Ottawa Canada.; Department of Biochemistry, Microbiology and Immunology University of Ottawa Ottawa Canada.

Publikováno v: Journal of extracellular biology [J Extracell Biol] 2024 Jul 17; Vol. 3 (7), pp. e166. Date of Electronic Publication: 2024 Jul 17 (Print Publication: 2024).

Targeting CD73 with flavonoids inhibits cancer stem cells and increases lymphocyte infiltration in a triple-negative breast cancer mouse model.

Autor: Mediratta K; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada.; The Centre for Infection, Immunity, and Inflammation (CI3), University of Ottawa, Ottawa, ON, Canada.; China-Canada Center of Research for Digestive Diseases (ccCRDD), Shanghai University of Traditional Chinese Medicine-University of Ottawa, Ottawa, ON, Canada., El-Sahli S; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada.; The Centre for Infection, Immunity, and Inflammation (CI3), University of Ottawa, Ottawa, ON, Canada.; China-Canada Center of Research for Digestive Diseases (ccCRDD), Shanghai University of Traditional Chinese Medicine-University of Ottawa, Ottawa, ON, Canada., Marotel M; The Centre for Infection, Immunity, and Inflammation (CI3), University of Ottawa, Ottawa, ON, Canada.; Ottawa Hospital Research Institute, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Awan MZ; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada.; The Centre for Infection, Immunity, and Inflammation (CI3), University of Ottawa, Ottawa, ON, Canada.; Department of Biotechnology, University of Azad Jammu and Kashmir, Muzaffarabad, Pakistan., Kirkby M; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada.; The Centre for Infection, Immunity, and Inflammation (CI3), University of Ottawa, Ottawa, ON, Canada.; China-Canada Center of Research for Digestive Diseases (ccCRDD), Shanghai University of Traditional Chinese Medicine-University of Ottawa, Ottawa, ON, Canada., Salkini A; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada.; The Centre for Infection, Immunity, and Inflammation (CI3), University of Ottawa, Ottawa, ON, Canada.; China-Canada Center of Research for Digestive Diseases (ccCRDD), Shanghai University of Traditional Chinese Medicine-University of Ottawa, Ottawa, ON, Canada., Kurdieh R; The Centre for Infection, Immunity, and Inflammation (CI3), University of Ottawa, Ottawa, ON, Canada.; Ottawa Hospital Research Institute, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Abdisalam S; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada.; The Centre for Infection, Immunity, and Inflammation (CI3), University of Ottawa, Ottawa, ON, Canada.; China-Canada Center of Research for Digestive Diseases (ccCRDD), Shanghai University of Traditional Chinese Medicine-University of Ottawa, Ottawa, ON, Canada., Shrestha A; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada.; The Centre for Infection, Immunity, and Inflammation (CI3), University of Ottawa, Ottawa, ON, Canada.; China-Canada Center of Research for Digestive Diseases (ccCRDD), Shanghai University of Traditional Chinese Medicine-University of Ottawa, Ottawa, ON, Canada., Di Censo C; Ottawa Hospital Research Institute, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy., Sulaiman A; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada.; The Centre for Infection, Immunity, and Inflammation (CI3), University of Ottawa, Ottawa, ON, Canada.; China-Canada Center of Research for Digestive Diseases (ccCRDD), Shanghai University of Traditional Chinese Medicine-University of Ottawa, Ottawa, ON, Canada.; Department of Pathology, John Hopkins University School of Medicine, Baltimore, MD, United States., McGarry S; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada.; The Centre for Infection, Immunity, and Inflammation (CI3), University of Ottawa, Ottawa, ON, Canada.; China-Canada Center of Research for Digestive Diseases (ccCRDD), Shanghai University of Traditional Chinese Medicine-University of Ottawa, Ottawa, ON, Canada., Lavoie JR; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Centre for Oncology, Radiopharmaceuticals and Research, Biologic and Radiopharmaceutical Drugs Directorate, Health Products and Food Branch, Health Canada, Ottawa, ON, Canada., Liu Z; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China., Lee SH; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; The Centre for Infection, Immunity, and Inflammation (CI3), University of Ottawa, Ottawa, ON, Canada., Li X; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Centre for Biologics Evaluation, Biologics and Genetic Therapies Directorate, Health Canada, Sir Frederick G. Banting Research Centre, Ottawa, ON, Canada., Sciumè G; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.; Instituto Pasteur Italia - Fondazione Cenci Bolognetti, Roma, Italy., D'Costa VM; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; The Centre for Infection, Immunity, and Inflammation (CI3), University of Ottawa, Ottawa, ON, Canada., Ardolino M; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; The Centre for Infection, Immunity, and Inflammation (CI3), University of Ottawa, Ottawa, ON, Canada.; Ottawa Hospital Research Institute, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Wang L; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada.; The Centre for Infection, Immunity, and Inflammation (CI3), University of Ottawa, Ottawa, ON, Canada.; China-Canada Center of Research for Digestive Diseases (ccCRDD), Shanghai University of Traditional Chinese Medicine-University of Ottawa, Ottawa, ON, Canada.; Ottawa Hospital Research Institute, Ottawa, ON, Canada.

Publikováno v: Frontiers in immunology [Front Immunol] 2024 Mar 27; Vol. 15, pp. 1366197. Date of Electronic Publication: 2024 Mar 27 (Print Publication: 2024).

A clinically relevant large-scale biomanufacturing workflow to produce natural killer cells and natural killer cell-derived extracellular vesicles for cancer immunotherapy.

Autor: St-Denis-Bissonnette F; Centre for Oncology, Radiopharmaceuticals and Research, Biologic and Radiopharmaceutical Drugs Directorate, Health Products and Food Branch, Health Canada, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Cummings SE; Centre for Oncology, Radiopharmaceuticals and Research, Biologic and Radiopharmaceutical Drugs Directorate, Health Products and Food Branch, Health Canada, Ottawa, ON, Canada., Qiu S; Centre for Oncology, Radiopharmaceuticals and Research, Biologic and Radiopharmaceutical Drugs Directorate, Health Products and Food Branch, Health Canada, Ottawa, ON, Canada., Stalker A; Centre for Oncology, Radiopharmaceuticals and Research, Biologic and Radiopharmaceutical Drugs Directorate, Health Products and Food Branch, Health Canada, Ottawa, ON, Canada., Muradia G; Centre for Oncology, Radiopharmaceuticals and Research, Biologic and Radiopharmaceutical Drugs Directorate, Health Products and Food Branch, Health Canada, Ottawa, ON, Canada., Mehic J; Centre for Oncology, Radiopharmaceuticals and Research, Biologic and Radiopharmaceutical Drugs Directorate, Health Products and Food Branch, Health Canada, Ottawa, ON, Canada., Mediratta K; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, ON, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada., Kaczmarek S; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, ON, Canada., Burger D; Kidney Research Centre, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada., Lee SH; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, ON, Canada., Wang L; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, ON, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada.; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Lavoie JR; Centre for Oncology, Radiopharmaceuticals and Research, Biologic and Radiopharmaceutical Drugs Directorate, Health Products and Food Branch, Health Canada, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.

Publikováno v: Journal of extracellular vesicles [J Extracell Vesicles] 2023 Dec; Vol. 12 (12), pp. e12387.