Zobrazeno 1 - 7 of 7 pro vyhledávání: '"Lavleen Mader"'
1
The war on hTG2: warhead optimization in small molecule human tissue transglutaminase inhibitors
Autor: Lavleen Mader, Sarah K. I. Watt, Harish R. Iyer, Linh Nguyen, Harpreet Kaur, Jeffrey W. Keillor
Publikováno v: RSC Medicinal Chemistry. 14:277-298
This systematic structure–activity relationship study provides key insights into warhead design and application for optimizing efficiency, selectivity, and pharmacokinetic stability of hTG2 inhibitors.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::20b06334a29ed3ee457f7f661ae9baad
https://doi.org/10.1039/d2md00378c
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2
A revised synthesis of 6-alkoxy-2-aminopurines with late-stage convergence allowing for increased molecular complexity
Autor: John Trant, John Hayward, Lisa A. Porter, Lavleen Mader
6-alkoxy-2-aminopurine derivatives are potent inhibitors of Cyclin Dependent Kinases (CDKs), with some selectivity towards CDK2 and thus have potential as cancer therapeutics. Development of these inhibitors for targeting CDK2-cyclin A/E complexes ha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebb81bb27b128331d4889086461edb20
https://doi.org/10.26434/chemrxiv-2022-zsk82
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3
Giving Preparative Thin-Layer Chromatography Some Tender ­Loving Care
Autor: John Trant, John Hayward, Lavleen Mader
Publikováno v: Chemistry and Biochemistry Publications
Preparative thin-layer chromatography (prepTLC) is a commonly used method of purification suitable for small-scale reactions. However, descriptions of the preferred methodology to load, run, and recover samples from prepTLC are non-standard and varie
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c74eb6f4980edb173c7973fe07be380
https://scholar.uwindsor.ca/context/chemistrybiochemistrypub/article/1231/viewcontent/TLC_article___Revised_2022_01_16__clean_copy__73__copy.pdf
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4
Identification of alternative protein targets of glutamate-ureido-lysine associated with PSMA tracer uptake in prostate cancer cells
Autor: Martin K. Bakht, John J. Hayward, Farsheed Shahbazi-Raz, Magdalena Skubal, Ryo Tamura, Keith F. Stringer, Daniel Meister, Varadha Balaji Venkadakrishnan, Hui Xue, Adam Pillon, Mathew Stover, Adam Tronchin, Bre-Anne Fifield, Lavleen Mader, Sheng-Yu Ku, Gi Jeong Cheon, Keon Wook Kang, Yuzhuo Wang, Xuesen Dong, Himisha Beltran, Jan Grimm, Lisa A. Porter, John F. Trant
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Chemistry and Biochemistry Publications
Significance Glutamate-ureido-lysine (GUL) probes are specific for prostate-specific membrane antigen (PSMA), overexpressed by most prostate cancers. This antigen can be lost as the cancer progresses. Recent reports have indicated that GUL probes can
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a29268542be1bc9269592b99513706d
https://doi.org/10.1073/pnas.2025710119
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5
Giving preparative thin layer chromatography some tender loving care
Autor: Lavleen Mader, John J. Hayward, John F. Trant
Preparative thin layer chromatography (prepTLC) is a commonly used method of purification suitable for small scale reactions. However, descriptions of the preferred methodology to load, run, and recover samples from prepTLC are non-standard and varie
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d7dcaa8e8342e22c65301d6ce068a952
https://doi.org/10.26434/chemrxiv-2021-6ddp9
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