Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Lavinia Nardinocchi"'
Autor:
Anna Tosi, Lavinia Nardinocchi, Maria Luigia Carbone, Lorena Capriotti, Elena Pagani, Simona Mastroeni, Cristina Fortes, Fernanda Scopelliti, Caterina Cattani, Francesca Passarelli, Antonio Rosato, Stefania D’Atri, Cristina Maria Failla, Andrea Cavani
Publikováno v:
Biomedicines, Vol 9, Iss 12, p 1930 (2021)
Characterization of tumor associated lymphocytes (TILs) in tumor lesions is important to obtain a clear definition of their prognostic value and address novel therapeutic opportunities. In this work, we examined the presence of T helper (Th)17 lympho
Externí odkaz:
https://doaj.org/article/6d896e8080424f5faed4de819df3f00c
Autor:
Lavinia Nardinocchi, Valentina Pantisano, Rosa Puca, Manuela Porru, Aurora Aiello, Annalisa Grasselli, Carlo Leonetti, Michal Safran, Gideon Rechavi, David Givol, Antonella Farsetti, Gabriella D'Orazi
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15048 (2010)
BackgroundHypoxia inducible factor-1α (HIF-1α) is responsible for the majority of HIF-1-induced gene expression changes under hypoxia and for the "angiogenic switch" during tumor progression. HIF-1α is often upregulated in tumors leading to more a
Externí odkaz:
https://doaj.org/article/ab2a4d89211047d4bc42ddf4cf41d1bc
Autor:
Cristina Lanni, Lavinia Nardinocchi, Rosa Puca, Serena Stanga, Daniela Uberti, Maurizio Memo, Stefano Govoni, Gabriella D'Orazi, Marco Racchi
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10171 (2010)
BackgroundHomeodomain interacting protein kinase 2 (HIPK2) is an evolutionary conserved serine/threonine kinase whose activity is fundamental in maintaining wild-type p53 function, thereby controlling the destiny of cells when exposed to DNA damaging
Externí odkaz:
https://doaj.org/article/dff16ab6748641c79065b852b6e8ba51
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6819 (2009)
BACKGROUND:The tumor suppressor homeodomain-interacting protein kinase-2 (HIPK2) by phosphorylating serine 46 (Ser46) is a crucial regulator of p53 apoptotic function. HIPK2 is also a transcriptional co-repressor of hypoxia-inducible factor-1alpha (H
Externí odkaz:
https://doaj.org/article/6926a083ff834ae28fd738d2b7018dc1
Autor:
Gabriella D'Orazi, David Givol, Giovanni Blandino, Ada Sacchi, Carlo Leonetti, Marco Scarsella, Daniel A. Notterman, Eytan Domany, Ninette Amariglio, Gideon Rechavi, Hilah Gal, Lavinia Nardinocchi, Rosa Puca
Supplementary Table 1 from Reversible Dysfunction of Wild-Type p53 following Homeodomain-Interacting Protein Kinase-2 Knockdown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b653139e3669877046d8c07b799efeb
https://doi.org/10.1158/0008-5472.22370273
https://doi.org/10.1158/0008-5472.22370273
Autor:
Gabriella D'Orazi, David Givol, Giovanni Blandino, Ada Sacchi, Carlo Leonetti, Marco Scarsella, Daniel A. Notterman, Eytan Domany, Ninette Amariglio, Gideon Rechavi, Hilah Gal, Lavinia Nardinocchi, Rosa Puca
About half of cancers sustain mutations in the TP53 gene, whereas the other half maintain a wild-type p53 (wtp53) but may compromise the p53 response because of other alterations. Homeodomain-interacting protein kinase-2 (HIPK2) is a positive regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::305e6f48f648eada4951304a3eef8cb2
https://doi.org/10.1158/0008-5472.c.6496337.v1
https://doi.org/10.1158/0008-5472.c.6496337.v1
Autor:
Andrea Cavani, Cristina Maria Failla, Giulio Sonego, Lavinia Nardinocchi, Cristina Albanesi, Stefano Simoni, Francesca Passarelli, Simona Avitabile, Claudia Scarponi
Publikováno v:
European Journal of Immunology. 45:922-931
Interleukin-17 (IL-17) and IL-22 have been reported to play critical roles in autoimmunity and inflammation but information about their role in cancer is limited. In this study, we investigated the role of IL-17 and IL-22 in the progression of human
Autor:
Gideon Rechavi, Lavinia Nardinocchi, David Givol, Rosa Puca, Amos J. Simon, Gabriella D'Orazi, Carlo Leonetti, Manuela Porru
Publikováno v:
Cell Cycle. 10:1679-1689
Absence of p53 expression or expression of mutant p53 (mtp53) are common in human cancers and are associated with increased cancer resistance to chemo- and radiotherapy. Therefore, significant efforts towards pharmaceutical reactivation of defective
Publikováno v:
Aging (Albany NY)
Many human diseases are characterized by the development of tissue hypoxia. Hypoxia-inducible factor (HIF) is a transcription factor that regulates fundamental cellular processes in response to changes in oxygen concentration, such as angiogenesis, s
Publikováno v:
FEBS Letters. 584:4253-4258
Homeodomain-interacting protein kinase-2 (HIPK2) is a crucial regulator of p53 apoptotic function by phosphorylating serine 46 (Ser46) in response to DNA damage. In tumors with wild-type p53, its tumor suppressor function is often impaired by MDM2 ov