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Clinically Actionable Hypercholesterolemia and Hypertriglyceridemia in Children with Nonalcoholic Fatty Liver Disease

Autor: Harlow, KE, Africa, JA, Wells, A, Belt, PH, Behling, CA, Jain, AK, Molleston, JP, Newton, KP, Rosenthal, P, Vos, MB, Xanthakos, SA, Lavine, JE, Schwimmer, JB, Abrams, SH, Barlow, S, Himes, R, Krisnamurthy, R, Maldonado, L, Mahabir, R, Carr, A, Bernstein, K, Bramlage, K, Cecil, K, DeVore, S, Kohli, R, Lake, K, Podberesky, D, Towbin, A, Behr, G, Lefkowitch, JH, Mencin, A, Reynoso, E, Alazraki, A, Cleeton, R, Cordero, M, Hernandez, A, Karpen, S, Munos, JC, Raviele, N, Bozic, M, Cummings, OW, Klipsch, A, Ragozzino, E, Sandrasegaran, K, Subbarao, G, Walker, L, Kafka, K, Scheimann, A, Ito, J, Fishbein, MH, Mohammad, S, Rigsby, C, Sharda, L, Whitington, PF, Cattoor, T, Derdoy, J, Freebersyser, J, King, D, Lai, J, Osmack, P, Siegner, J, Stewart, S, Torretta, S, Wriston, K, Baker, SS, Lopez-Graham, D, Williams, S, Zhu, L, Awai, H, Bross, C, Collins, J, Durelle, J, Middleton, M, Paiz, M, Sirlin, C, Ugalde-Nicalo, P, Villarreal, MD, Aouizerat, B, Courtier, J, Ferrell, LD, Feier, N, Gill, R, Langlois, C, Perito, ER, Tsai, P, Cooper, K, Horslen, S, Hsu, E, Murray, K, Otto, R, Yeh, M, Young, M, Brunt, EM, Fowler, K

Publikováno v: Harlow, KE; Africa, JA; Wells, A; Belt, PH; Behling, CA; Jain, AK; et al.(2018). Clinically Actionable Hypercholesterolemia and Hypertriglyceridemia in Children with Nonalcoholic Fatty Liver Disease. Journal of Pediatrics, 198, 76-83.e2. doi: 10.1016/j.jpeds.2018.02.038. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/2386g6hb

© 2018 Elsevier Inc. Objective: To determine the percentage of children with nonalcoholic fatty liver disease (NAFLD) in whom intervention for low-density lipoprotein cholesterol or triglycerides was indicated based on National Heart, Lung, and Bloo

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Diagnostic accuracy of magnetic resonance imaging hepatic proton density fat fraction in pediatric nonalcoholic fatty liver disease

Autor: Middleton, MS, Van Natta, ML, Heba, ER, Alazraki, A, Trout, AT, Masand, P, Brunt, EM, Kleiner, DE, Doo, E, Tonascia, J, Lavine, JE, Shen, W, Hamilton, G, Schwimmer, JB, Sirlin, CB, Network, NASHCR

Publikováno v: Hepatology (Baltimore, Md.), vol 67, iss 3
Middleton, MS; Van Natta, ML; Heba, ER; Alazraki, A; Trout, AT; Masand, P; et al.(2018). Diagnostic accuracy of magnetic resonance imaging hepatic proton density fat fraction in pediatric nonalcoholic fatty liver disease. HEPATOLOGY, 67(3), 858-872. doi: 10.1002/hep.29596. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/9gq4p1zb

We assessed the performance of magnetic resonance imaging (MRI) proton density fat fraction (PDFF) in children to stratify hepatic steatosis grade before and after treatment in the Cysteamine Bitartrate Delayed-Release for the Treatment of Nonalcohol

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In Children With Nonalcoholic Fatty Liver Disease, Zone 1 Steatosis Is Associated With Advanced Fibrosis

Autor: Africa, JA, Behling, CA, Brunt, EM, Zhang, N, Luo, Y, Wells, A, Hou, J, Belt, PH, Kohil, R, Lavine, JE, Molleston, JP, Newton, KP, Whitington, PF, Schwimmer, JB, Abrams, SH, Barlow, S, Himes, R, Krisnamurthy, R, Maldonado, L, Mahabir, R, Carr, A, Bernstein, K, Bramlage, K, Cecil, K, DeVore, S, Kohli, R, Lake, K, Podberesky, D, Towbin, A, Xanthakos, S, Behr, G, Lefkowitch, JH, Mencin, A, Reynoso, E, Alazraki, A, Cleeton, R, Cordero, M, Hernandez, A, Karpen, S, Munos, JC, Raviele, N, Vos, M, Bozic, M, Cummings, OW, Klipsch, A, Ragozzino, E, Sandrasegaran, K, Subbarao, G, Walker, L, Kafka, K, Scheimann, A, Ito, J, Fishbein, MH, Mohammad, S, Rigsby, C, Sharda, L, Cattoor, T, Derdoy, J, Freebersyser, J, Jain, A, King, D, Lai, J, Osmack, P, Siegner, J, Stewart, S, Torretta, S, Wriston, K, Baker, SS, Lopez-Graham, D, Williams, S, Zhu, L, Awai, H, Behling, C, Bross, C, Collins, J, Durelle, J, Harlow, K, Middleton, M, Paiz, M, Sirlin, C, Ugalde-Nicalo, P, Villarreal, MD, Aouizerat, B, Courtier, J, Ferrell, LD, Feier, N, Gill, R, Langlois, C

Publikováno v: Africa, JA; Behling, CA; Brunt, EM; Zhang, N; Luo, Y; Wells, A; et al.(2018). In Children With Nonalcoholic Fatty Liver Disease, Zone 1 Steatosis Is Associated With Advanced Fibrosis. Clinical Gastroenterology and Hepatology, 16(3), 438-446.e1. doi: 10.1016/j.cgh.2017.02.030. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/2g75d87d

© 2018 AGA Institute Background & Aims: Focal zone 1 steatosis, although rare in adults with nonalcoholic fatty liver disease (NAFLD), does occur in children with NAFLD. We investigated whether focal zone 1 steatosis and focal zone 3 steatosis are d

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Agreement Between Magnetic Resonance Imaging Proton Density Fat Fraction Measurements and Pathologist-Assigned Steatosis Grades of Liver Biopsies From Adults With Nonalcoholic Steatohepatitis

Autor: Middleton, MS, Heba, ER, Hooker, CA, Bashir, MR, Fowler, KJ, Sandrasegaran, K, Brunt, EM, Kleiner, DE, Doo, E, Van Natta, ML, Lavine, JE, Neuschwander-Tetri, BA, Sanyal, A, Loomba, R, Sirlin, CB, Network, NASHCR

Publikováno v: Gastroenterology, vol 153, iss 3
Middleton, MS; Heba, ER; Hooker, CA; Bashir, MR; Fowler, KJ; Sandrasegaran, K; et al.(2017). Agreement Between Magnetic Resonance Imaging Proton Density Fat Fraction Measurements and Pathologist-Assigned Steatosis Grades of Liver Biopsies From Adults With Nonalcoholic Steatohepatitis. GASTROENTEROLOGY, 153(3), 753-761. doi: 10.1053/j.gastro.2017.06.005. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/45v0g180

Background & aimsWe assessed the diagnostic performance of magnetic resonance imaging (MRI) proton density fat fraction (PDFF) in grading hepatic steatosis and change in hepatic steatosis in adults with nonalcoholic steatohepatitis (NASH) in a multi-

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Patient Sex, Reproductive Status, and Synthetic Hormone Use Associate With Histologic Severity of Nonalcoholic Steatohepatitis

Autor: Yang, JD, Abdelmalek, MF, Guy, CD, Gill, RM, Lavine, JE, Yates, K, Klair, J, Terrault, NA, Clark, JM, Unalp-Arida, A, Diehl, AM, Suzuki, A, Dasarathy, S, Dasarathy, J, Hawkins, C, McCullough, AJ, Pagadala, M, Pai, R, Sargent, R, Bashir, M, Buie, S, Guy, C, Kigongo, C, Pan, YP, Piercy, D, Chalasani, N, Cummings, OW, Gawrieh, S, Ghabril, M, Marri, S, Ragozzino, L, Sandrasegaran, K, Vuppalanchi, R, King, D, Osmack, P, Siegner, J, Stewart, S, Neuschwander-Tetri, BA, Torretta, S, Ang, B, Behling, C, Bhatt, A, Loomba, R, Middleton, M, Patton, H, Sirlin, C, Aouizerat, B, Bass, NM, Brandman, D, Ferrell, LD, Gill, R, Hameed, B, Ramos, C, Terrault, N, Ungermann, A, Atla, P, Croft, B, Garcia, R, Garcia, S, Sheikh, M, Singh, M, Boyett, S, Carucci, L, Contos, MJ, Kraft, K, Luketic, VAC, Puri, P, Sanyal, AJ, Schlosser, J, Siddiqui, MS, Wolford, B, Ackermann, S, Cooney, S, Coy, D, Gelinas, K, Kowdley, KV, Lee, M, Pierce, T, Mooney, J, Nelson, JE, Shaw, C, Siddique, A, Wang, C, Brunt, EM, Fowler, K, Kleiner, DE, Grave, GD, Doo, EC, Hoofnagle, JH, Robuck, PR, Sherker, A, Belt, P, Donithan, M

Publikováno v: Yang, JD; Abdelmalek, MF; Guy, CD; Gill, RM; Lavine, JE; Yates, K; et al.(2017). Patient Sex, Reproductive Status, and Synthetic Hormone Use Associate With Histologic Severity of Nonalcoholic Steatohepatitis. Clinical Gastroenterology and Hepatology, 15(1), 127-131.e2. doi: 10.1016/j.cgh.2016.07.034. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/7h29p34c

© 2017 AGA Institute Background & Aims Sex and sex hormones can affect responses of patients with nonalcoholic fatty liver disease (NAFLD) to metabolic stress and development of hepatocyte injury and inflammation. Methods We collected data from 3 la

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In Children With Nonalcoholic Fatty Liver Disease, Cysteamine Bitartrate Delayed Release Improves Liver Enzymes but Does Not Reduce Disease Activity Scores

Autor: Schwimmer, JB, Lavine, JE, Wilson, LA, Neuschwander-Tetri, BA, Xanthakos, SA, Kohli, R, Barlow, SE, Vos, MB, Karpen, SJ, Molleston, JP, Whitington, PF, Rosenthal, P, Jain, AK, Murray, KF, Brunt, EM, Kleiner, DE, Van Natta, ML, Clark, JM, Tonascia, J, Doo, E, Abrams, SH, Barlow, S, Himes, R, Krisnamurthy, R, Maldonado, L, Mahabir, R, Bernstein, K, Bramlage, K, Cecil, K, DeVore, S, Lake, K, Podberesky, D, Towbin, A, Xanthakos, S, Behr, G, Lefkowitch, JH, Mencin, A, Reynoso, E, Alazraki, A, Cleeton, R, Karpen, S, Cruz Munos, J, Raviele, N, Vos, M, Bozic, M, Cummings, OW, Klipsch, A, Munson, S, Sandrasegaran, K, Subbarao, G, Kafka, K, Scheimann, A, Amsden, K, Fishbein, MH, Kirwan, E, Mohammad, S, Rigsby, C, Sharda, L, Derdoy, J, Jain, A, King, D, Osmack, P, Siegner, J, Stewart, S, Torretta, S, Wriston, K, Baker, SS, Zhu, L, Africa, J, Angeles, J, Arroyo, S, Awai, H, Behling, C, Bross, C, Durelle, J, Middleton, M, Newton, K, Paiz, M, Sanford, J, Sirlin, C, Ugalde-Nicalo, P, Villarreal, MD, Aouizerat, B, Courtier, J, Ferrell, LD, Fleck, S, Gill, R

Publikováno v: Schwimmer, JB; Lavine, JE; Wilson, LA; Neuschwander-Tetri, BA; Xanthakos, SA; Kohli, R; et al.(2016). In Children With Nonalcoholic Fatty Liver Disease, Cysteamine Bitartrate Delayed Release Improves Liver Enzymes but Does Not Reduce Disease Activity Scores. Gastroenterology, 151(6), 1141-1154.e9. doi: 10.1053/j.gastro.2016.08.027. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/2h61w9m6

© 2016 AGA Institute Background & Aims No treatment for nonalcoholic fatty liver disease (NAFLD) has been approved by regulatory agencies. We performed a randomized controlled trial to determine whether 52 weeks of cysteamine bitartrate delayed rele

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Feasibility of and agreement between MR imaging and spectroscopic estimation of hepatic proton density fat fraction in children with known or suspected nonalcoholic fatty liver disease

Autor: Achmad, E, Yokoo, T, Hamilton, G, Heba, ER, Hooker, JC, Changchien, C, Schroeder, M, Wolfson, T, Gamst, A, Schwimmer, JB, Lavine, JE, Sirlin, CB, Middleton, MS

Publikováno v: Achmad, E; Yokoo, T; Yokoo, T; Hamilton, G; Heba, ER; Hooker, JC; et al.(2015). Feasibility of and agreement between MR imaging and spectroscopic estimation of hepatic proton density fat fraction in children with known or suspected nonalcoholic fatty liver disease. Abdominal Imaging. doi: 10.1007/s00261-015-0506-9. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/0mt5p7qg

© 2015 Springer Science+Business Media New York Purpose: To assess feasibility of and agreement between magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) for estimating hepatic proton density fat fraction (PDFF) in children

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Iron deficiency in patients with nonalcoholic fatty liver disease is associated with obesity, female gender, and low serum hepcidin

Autor: Siddique, A, Nelson, JE, Aouizerat, B, Yeh, MM, Kowdley, KV, Abrams, SH, Himes, R, Krisnamurthy, R, Maldonado, L, Morris, B, Brandt, P, Dasarathy, S, Dasarathy, J, Hawkins, C, McCullough, AJ, Pagadala, M, Pai, R, Sargent, R, Shah, S, Zein, C, Bernstein, K, Cecil, K, DeVore, S, Kohli, R, Lake, K, Podberesky, D, Slaughter, C, Xanthakos, S, Behr, G, Lavine, JE, Mencin, A, Ovchinsky, N, Reynoso, E, Abdelmalek, MF, Bashir, M, Buie, S, Diehl, AM, Guy, C, Kigongo, C, Pan, YP, Piercy, D, Wagner, M, Alazraki, A, Cleeton, R, Karpen, S, Raviele, N, Vos, M, Byam, E, Chalasani, N, Cummings, OW, Fleming, C, Ghabril, M, Klipsch, A, Marri, S, Molleston, JP, Ragozzino, L, Sandrasegaran, K, Subbarao, G, Vuppalanchi, R, Pfeifer, K, Scheimann, A, Torbenson, M, Arnon, R, Boyd, M, Amsden, K, Fishbein, MH, Kirwan, E, Mohammad, S, Quinn, A, Rigsby, C, Whitington, PF, Barlow, S, Derdoy, J, Jain, A, King, D, Osmack, P, Siegner, J, Stewart, S, Neuschwander-Tetri, BA, Romo, D, Ang, B, Arroyo, S, Behling, C, Bhatt, A, Collins, J, Doycheva, I, Durelle, J, Hassanein, T, Loomba, R, Middleton, M, Newton, K

Publikováno v: Siddique, A; Nelson, JE; Aouizerat, B; Yeh, MM; Kowdley, KV; Abrams, SH; et al.(2014). Iron deficiency in patients with nonalcoholic fatty liver disease is associated with obesity, female gender, and low serum hepcidin. Clinical Gastroenterology and Hepatology, 12(7), 1170-1178. doi: 10.1016/j.cgh.2013.11.017. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/3161v737

Background & Aims: Iron deficiency is often observed in obese individuals. The iron regulatory hormone hepcidin is regulated by iron and cytokines interleukin (IL) 6 and IL1β. We examine the relationship between obesity, circulating levels of hepcid

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Estimation of fish and ω-3 fatty acid intake in pediatric nonalcoholic fatty liver disease

Autor: St-Jules, DE, Watters, CA, Brunt, EM, Wilkens, LR, Novotny, R, Belt, P, Lavine, JE, Abrams, SH, Himes, R, Krisnamurthy, R, Maldonado, L, Morris, B, Bernstein, K, Cecil, K, DeVore, S, Kohli, R, Lake, K, Podberesky, D, Slaughter, C, Xanthakos, S, Behr, G, Mencin, A, Ovchinsky, N, Reynoso, E, Alazraki, A, Cleeton, R, Karpen, S, Raviele, N, Vos, M, Byam, E, Cummings, OW, Fleming, C, Klipsch, A, Molleston, JP, Sandrasegaran, K, Subbarao, G, Pfeifer, K, Scheimann, A, Torbenson, M, Clark, JM, Corless, E, Donithan, M, Isaacson, M, May, KP, Miriel, L, Sternberg, A, Tonascia, J, Ünalp-Arida, A, Van Natta, M, Vaughn, I, Wilson, L, Yates, K, Arnon, R, Boyd, M, Amsden, K, Fishbein, MH, Kirwan, E, Mohammad, S, Quinn, A, Rigsby, C, Whitington, PF, Barlow, S, Derdoy, J, Jain, A, King, D, Osmack, P, Siegner, J, Stewart, S, Romo, D, Arroyo, S, Behling, C, Collins, J, Durelle, J, Middleton, M, Newton, K, Paiz, M, Schwimmer, JB, Sirlin, C, Ugalde-Nicalo, P, Aouizerat, B, Ferrell, LD, Fleck, S, Gill, R, Langlois, C, Perito, ER, Rosenthal, P, Tsai, P, Cooper, K, Horslen, S, Hsu, E, Murray, K, Otto, R, Rich, D, Yeh, M, Young, M, Fowler, K

Publikováno v: St-Jules, DE; Watters, CA; Brunt, EM; Wilkens, LR; Novotny, R; Belt, P; et al.(2013). Estimation of fish and ω-3 fatty acid intake in pediatric nonalcoholic fatty liver disease. Journal of Pediatric Gastroenterology and Nutrition, 57(5), 627-633. doi: 10.1097/MPG.0b013e3182a1df77. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/69t8p483

AIMS:: Fish and ω-3 fatty acids are reported to be beneficial in pediatric nonalcoholic fatty liver disease (NAFLD), but no studies have assessed their relation to histological severity. The objectives of this study were to evaluate the dietary inta

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