Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Lavina, Gharu"'
Directing HIV-1 for degradation by non-target cells, using bi-specific single-chain llama antibodies
Autor:
Jord C. Stam, Steven de Maat, Dorien de Jong, Mathia Arens, Fenna van Lint, Lavina Gharu, Mark H. van Roosmalen, Rob C. Roovers, Nika M. Strokappe, Ralf Wagner, Alexander Kliche, Hans J. de Haard, Paul M. van Bergen en Henegouwen, Monique Nijhuis, C. Theo Verrips
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract While vaccination against HIV-1 has been so far unsuccessful, recently broadly neutralizing antibodies (bNAbs) against HIV-1 envelope glycoprotein were shown to induce long-term suppression in the absence of antiretroviral therapy in patient
Externí odkaz:
https://doaj.org/article/ffdba455ddae44ce8e6074f6be3806a7
Autor:
Stephanie B. H. Gumbs, Amber Berdenis van Berlekom, Raphael Kübler, Pauline J. Schipper, Lavina Gharu, Marco P. Boks, Paul R. Ormel, Annemarie M. J. Wensing, Lot D. de Witte, Monique Nijhuis
Publikováno v:
Viruses, Vol 14, Iss 4, p 829 (2022)
The achievement of an HIV cure is dependent on the eradication or permanent silencing of HIV-latent viral reservoirs, including the understudied central nervous system (CNS) reservoir. This requires a deep understanding of the molecular mechanisms of
Externí odkaz:
https://doaj.org/article/2321f20662244c68ae92d104af4ad726
Autor:
Marieke M, Nühn, Stephanie B H, Gumbs, Ninée V E J, Buchholtz, Lisanne M, Jannink, Lavina, Gharu, Lot D, de Witte, Annemarie M J, Wensing, Sharon R, Lewin, Monique, Nijhuis, Jori, Symons
Publikováno v:
Journal of Leukocyte Biology. 112:1297-1315
The most studied HIV eradication approach is the “shock and kill” strategy, which aims to reactivate the latent reservoir by latency reversing agents (LRAs) and allowing elimination of these cells by immune-mediated clearance or viral cytopathic
Autor:
Ambra Sarracino, Lavina Gharu, Anna Kula, Alexander O. Pasternak, Veronique Avettand-Fenoel, Christine Rouzioux, Maryana Bardina, Stéphane De Wit, Monsef Benkirane, Ben Berkhout, Carine Van Lint, Alessandro Marcello
Publikováno v:
mBio, Vol 9, Iss 6 (2018)
ABSTRACT Posttranscriptional regulation of HIV-1 replication is finely controlled by viral and host factors. Among the former, Rev controls the export of partially spliced and unspliced viral RNAs from the nucleus and their translation in the cytopla
Externí odkaz:
https://doaj.org/article/3d530f8882d84aa193a7b60198add2d7
Autor:
Jeffrey S. Miller, Zachary B. Davis, Erika Helgeson, Cavan Reilly, Ann Thorkelson, Jodi Anderson, Noemia S. Lima, Siri Jorstad, Geoffrey T. Hart, John H. Lee, Jeffrey T. Safrit, Hing Wong, Sarah Cooley, Lavina Gharu, Hyunsoo Chung, Patrick Soon-Shiong, Curtis Dobrowolski, Courtney V. Fletcher, Jonathan Karn, Daniel C. Douek, Timothy W. Schacker
Publikováno v:
Nature Medicine. 28:392-400
There is no cure for HIV infection, and lifelong antiretroviral therapy (ART) is required. N-803 is an IL-15 superagonist comprised of an N72D mutant IL-15 molecule attached to its alpha receptor and a human IgG1 fragment designed to increase IL-15 a
Autor:
Krystelle Nganou-Makamdop, James M Billingsley, Zachary Yaffe, Gregory O'Connor, Gregory K Tharp, Amy Ransier, Farida Laboune, Rodrigo Matus-Nicodemos, Andrea Lerner, Lavina Gharu, Jennifer M Robertson, Mandy L Ford, Martin Schlapschy, Nadine Kuhn, Alexandra Lensch, Jeffrey Lifson, Martha Nason, Arne Skerra, Gideon Schreiber, Steven E Bosinger, Daniel C Douek
Publikováno v:
PLoS Pathogens, Vol 14, Iss 8, p e1007246 (2018)
Chronic activation of the immune system in HIV infection is one of the strongest predictors of morbidity and mortality. As such, approaches that reduce immune activation have received considerable interest. Previously, we demonstrated that administra
Externí odkaz:
https://doaj.org/article/222e9d607de04416ad02ccb59781e2f1
Autor:
Christine Rouzioux, Ben Berkhout, Monsef Benkirane, Alessandro Marcello, Anna Kula, Lavina Gharu, Stéphane De Wit, Véronique Avettand-Fenoel, Alexander O. Pasternak, Ambra Sarracino, Maryana Bardina, Carine Van Lint
Publikováno v:
mBio, Vol 9, Iss 6 (2018)
mBio, Vol 9, Iss 6, p e02158-18 (2018)
MBio, 9 (6
mBio
mBio, 9(6). American Society for Microbiology
mBio, Vol 9, Iss 6, p e02158-18 (2018)
MBio, 9 (6
mBio
mBio, 9(6). American Society for Microbiology
Posttranscriptional regulation of HIV-1 replication is finely controlled by viral and host factors. Among the former, Rev controls the export of partially spliced and unspliced viral RNAs from the nucleus and their translation in the cytoplasm or inc
Autor:
Lavina Gharu, Alessandro Marcello
Publikováno v:
Encyclopedia of AIDS ISBN: 9781461496106
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57703afc474c9f8af7caeff24eb61a99
https://doi.org/10.1007/978-1-4939-7101-5_402
https://doi.org/10.1007/978-1-4939-7101-5_402
Publikováno v:
Virus Research. 158:216-224
The mechanism by which strictly CCR5 using HIV-1 clade C variants exacerbate disease progression in absence of coreceptor switch is not clearly known. We previously reported HIV-1 clade C envelopes (Env) obtained from late stage Indian patients with
Publikováno v:
AIDS Research and Human Retroviruses. 27:211-219
HIV-1 clade C is the major subtype circulating in India and preferentially uses CCR5 during the entire disease course. We have recently shown that env clones from an Indian patient; NARI-VB105 uses multiple coreceptors for entry and was presented wit