DNA-PK inhibition shows differential radiosensitization in orthotopic GBM PDX models based on DDR pathway deficits.

Autor: Dragojevic S; Mayo Clinic, Rochester, Minnesota, United States., Smith EJ; Mayo Clinic, Rochester, Minnesota, United States., Regan MS; Brigham and Women's Hospital, Boston, MA, United States., Stopka SA; Brigham and Women's Hospital, Boston, United States., Baquer G; Brigham and Women's Hospital, Boston, MA, United States., Xue Z; Mayo Clinic, Rochester, Minnesota, United States., Zhang W; University of Minnesota, Minneapolis, MN, United States., Connors MA; Mayo Clinic, Rochester, Minnesota, United States., Kloeber JA; Mayo Clinic, Rochester, MN, United States., Hu Z; Mayo Clinic, Rochester, MN, United States., Bakken KK; Mayo Clinic, Rochester, MN, United States., Ott LL; Mayo Clinic, Rochester, Minnesota, United States., Carlson BL; Mayo Clinic, Rochester, United States., Burgenske DM; Mayo Clinic, Rochester, MN, United States., Decker PA; Mayo Clinic, Rochester, United States., Tian S; Mayo Clinic, United States., Gupta SK; Mayo Clinic, Rochester, MN, United States., Laverty DJ; Harvard T.H. Chan School of Public Health, Boston, MA, United States., Eckel-Passow JE; Mayo Clinic, Rochester, MN, United States., Elmquist WF; University of Minnesota, Minneapolis, MN, United States., Agar NYR; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States., Nagel ZD; Harvard T.H. Chan School of Public Health, Boston, MA, United States., Sarkaria JN; Mayo Clinic, Rochester, MN, United States., Callaghan CM; Mayo Clinic, Rochester, MN, United States.

Publikováno v: Molecular cancer therapeutics [Mol Cancer Ther] 2024 Oct 23. Date of Electronic Publication: 2024 Oct 23.

CDK-independent role of D-type cyclins in regulating DNA mismatch repair.

Autor: Rona G; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA; Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY 10016, USA; Howard Hughes Medical Institute, NYU Grossman School of Medicine, New York, NY 10016, USA., Miwatani-Minter B; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA; Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY 10016, USA., Zhang Q; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA; Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY 10016, USA., Goldberg HV; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA; Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY 10016, USA., Kerzhnerman MA; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA; Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY 10016, USA., Howard JB; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA; Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY 10016, USA., Simoneschi D; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA; Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY 10016, USA., Lane E; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA; Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY 10016, USA., Hobbs JW; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA; Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY 10016, USA., Sassani E; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA; Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY 10016, USA., Wang AA; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA; Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY 10016, USA., Keegan S; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA; Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY 10016, USA; Institute for Systems Genetics, NYU Grossman School of Medicine, New York, NY 10016, USA., Laverty DJ; Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA., Piett CG; Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA., Pongor LS; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA; Cancer Genomics and Epigenetics Core Group, Hungarian Centre of Excellence for Molecular Medicine, Szeged 6728, Hungary., Xu ML; Department of Cancer Biology, Dana-Farber Cancer Institute, and Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02215, USA., Andrade J; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA; Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY 10016, USA., Thomas A; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Sicinski P; Department of Cancer Biology, Dana-Farber Cancer Institute, and Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02215, USA; Department of Histology and Embryology, Center for Biostructure Research, Medical University of Warsaw, Chalubinskiego 5, 02-004 Warsaw, Poland., Askenazi M; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA; Biomedical Hosting LLC, 33 Lewis Avenue, Arlington, MA 02474, USA., Ueberheide B; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA; Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY 10016, USA., Fenyö D; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA; Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY 10016, USA; Institute for Systems Genetics, NYU Grossman School of Medicine, New York, NY 10016, USA., Nagel ZD; Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA., Pagano M; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA; Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY 10016, USA; Howard Hughes Medical Institute, NYU Grossman School of Medicine, New York, NY 10016, USA. Electronic address: michele.pagano@nyulangone.org.

Publikováno v: Molecular cell [Mol Cell] 2024 Apr 04; Vol. 84 (7), pp. 1224-1242.e13. Date of Electronic Publication: 2024 Mar 07.

D-type cyclins regulate DNA mismatch repair in the G1 and S phases of the cell cycle, maintaining genome stability.

Autor: Rona G; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA.; Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY 10016, USA.; Howard Hughes Medical Institute, NYU Grossman School of Medicine, New York, NY 10016, USA., Miwatani-Minter B; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA.; Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY 10016, USA., Zhang Q; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA.; Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY 10016, USA., Goldberg HV; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA.; Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY 10016, USA., Kerzhnerman MA; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA.; Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY 10016, USA., Howard JB; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA.; Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY 10016, USA., Simoneschi D; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA.; Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY 10016, USA., Lane E; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA.; Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY 10016, USA., Hobbs JW; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA.; Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY 10016, USA., Sassani E; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA.; Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY 10016, USA., Wang AA; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA.; Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY 10016, USA., Keegan S; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA.; Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY 10016, USA.; Institute for Systems Genetics, NYU Grossman School of Medicine, New York, NY 10016, USA., Laverty DJ; Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA., Piett CG; Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA., Pongor LS; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.; Hungarian Centre of Excellence for Molecular Medicine, University of Szeged, Szeged, H-6728, Hungary., Xu ML; Department of Cancer Biology, Dana-Farber Cancer Institute, and Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02215, USA., Andrade J; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA.; Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY 10016, USA., Thomas A; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Sicinski P; Department of Cancer Biology, Dana-Farber Cancer Institute, and Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02215, USA.; Department of Histology and Embryology, Center for Biostructure Research, Medical University of Warsaw, Chalubinskiego 5, 02-004 Warsaw, Poland., Askenazi M; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA.; Biomedical Hosting LLC, 33 Lewis Avenue, Arlington, MA 02474, USA., Ueberheide B; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA.; Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY 10016, USA., Fenyö D; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA.; Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY 10016, USA.; Institute for Systems Genetics, NYU Grossman School of Medicine, New York, NY 10016, USA., Nagel ZD; Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA., Pagano M; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA.; Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY 10016, USA.; Howard Hughes Medical Institute, NYU Grossman School of Medicine, New York, NY 10016, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jan 13. Date of Electronic Publication: 2024 Jan 13.

ATM phosphorylates the FATC domain of DNA-PKcs at threonine 4102 to promote non-homologous end joining.

Autor: Lu H; Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, TX75390, USA., Zhang Q; Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, TX75390, USA., Laverty DJ; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA02115, USA., Puncheon AC; Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, TX75390, USA., Augustine MM; Division of Surgical Oncology, Department of Surgery, UT Southwestern Medical Center, Dallas, TX75390, USA.; Department of Surgery, North Texas VA Medical Center, Dallas, TX75216, USA., Williams GJ; Department of Biochemistry and Molecular Biology, Robson DNA Science Centre, Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Nagel ZD; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA02115, USA., Chen BPC; Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, TX75390, USA., Davis AJ; Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, TX75390, USA.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2023 Jul 21; Vol. 51 (13), pp. 6770-6783.

Correction to "Selective Inhibition of DNA Polymerase β by a Covalent Inhibitor".

Autor: Yuhas SC, Laverty DJ, Lee H, Majumdar A, Greenberg MM

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2022 Feb 16; Vol. 144 (6), pp. 2825. Date of Electronic Publication: 2022 Feb 03.