Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Lavendamycin"'
Akademický článek
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Akademický článek
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Publikováno v:
Applied Microbiology and Biotechnology. 98:4399-4407
Lavendamycin methyl ester (LME) is a derivative of a highly functionalized aminoquinone alkaloid lavendamycin and could be used as a scaffold for novel anticancer agent development. This work demonstrated LME production by cultivation of an engineere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32d343d0f58b889d6c1d7863dc8e4c09
https://doi.org/10.1007/s00253-014-5555-4
https://doi.org/10.1007/s00253-014-5555-4
Akademický článek
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Publikováno v:
Tetrahedron. 69:4890-4898
A convergent synthesis of lavendamycin analogues has been accomplished by using A3 coupling reaction between carboline aldehydes, anilines, and phenylacetylenes. Our approach features the use of the ionic liquids as an environmentally benign solvent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5589f854f00c44b6c1034ffd0db331b2
https://doi.org/10.1016/j.tet.2013.04.074
https://doi.org/10.1016/j.tet.2013.04.074
Autor:
Liping Zhang, Xinqiang Xie, Zhang Zhang, Peng Wang, Hairong Cheng, Fei Xu, Zixin Deng, Xinyi He, Meifeng Tao, Shuangjun Lin, Dekun Kong, Mo Han
Publikováno v:
Journal of the American Chemical Society. 135:1739-1748
Streptonigrin (STN, 1) is a highly functionalized aminoquinone alkaloid with broad and potent antitumor activity. Here, we reported the biosynthetic gene cluster of STN identified by genome scanning of a STN producer Streptomyces flocculus CGMCC4.122
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1a8afa890e3ff2a28767bec4a327e55
https://doi.org/10.1021/ja3069243
https://doi.org/10.1021/ja3069243
Autor:
Heiner Detert, Felix Nissen
Publikováno v:
European Journal of Organic Chemistry. 2011:2845-2853
The total synthesis of the bacterial-derived, pentacyclic, antitumor antibiotic lavendamycin has been achieved through a highly convergent strategy. The key step of this synthesis is a ruthenium-catalyzed [2+2+2] cycloaddition of an electron-deficien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ccf5f988560923770ebc909eb064f39
https://doi.org/10.1002/ejoc.201100131
https://doi.org/10.1002/ejoc.201100131
Autor:
Wen Cai, Mary Hassani, Nicholas G. Hermann, Anthony S. Rose, Jennifer S. Lucas, Thomas J. Eads, Ervin D. Walter, Minoo Sedighi, Sahba Charkhzarrin, Katherine H. Koelsch, Mohammad Behforouz, Hamid Mirzaei, Fatemeh Olang, Howard D. Beall, Hassan Seradj, Rajesh Karki, Jayana P. Lineswala, Jeremy S. York
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:1899-1909
A series of lavendamycin analogues with two, three or four substituents at the C-6, C-7 N, C-2′, C-3′ and C-11′ positions were synthesized via short and efficient methods and evaluated as potential NAD(P)H:quinone oxidoreductase (NQO1)-directed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1216665b2bf05aa18601a35f725778f6
https://doi.org/10.1016/j.bmc.2010.01.037
https://doi.org/10.1016/j.bmc.2010.01.037
Publikováno v:
Tetrahedron. 66:1496-1502
Indole-substituted N-propargylamides undergo a gold(III)-catalyzed cyclization to give oxazoles or β-carbolinones, depending on the substitution pattern at the amide nitrogen. Secondary amides furnished oxazoles via a 5-exo-dig cyclization, while te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c1b8d5044ac0877fb704337d2fcef9e
https://doi.org/10.1016/j.tet.2009.10.033
https://doi.org/10.1016/j.tet.2009.10.033
Autor:
Howard D. Beall, Jayana P. Lineswala, William Glen Holloway, Wen Cai, Fatemeh Olang, Mohammad Behforouz, John M. Gerdes, Katherine H. Koelsch, David C. Holley, Mary Hassani, Anthony S. Rose
Publikováno v:
Journal of Medicinal Chemistry. 51:3104-3115
A 1H69 crystal structure-based in silico model of the NAD(P)H:quinone oxidoreductase 1 (NQO1) active site has been developed to facilitate NQO1-directed lavendamycin antitumor agent development. Lavendamycin analogues were designed as NQO1 substrates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b17e014a7ec0d780a03a98a1fd2fa12
https://doi.org/10.1021/jm701066a
https://doi.org/10.1021/jm701066a