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Challenges and opportunities with modelling and simulation in drug discovery and drug development.

Autor: Lavé, T.¹ (AUTHOR) thierry.lave@roche.com, Parrott, N.¹ (AUTHOR), Grimm, H. P.¹ (AUTHOR), Fleury, A.¹ (AUTHOR), Reddy, M.² (AUTHOR)

Publikováno v: Xenobiotica. Oct/Nov2007, Vol. 37 Issue 10/11, p1295-1310. 16p. 3 Diagrams, 3 Charts, 1 Graph.

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Anti-Acinetobacter baumannii single-chain variable fragments provide therapeutic efficacy in an immunocompromised mouse pneumonia model.

Autor: Basardeh, Eilnaz¹ (AUTHOR), Piri-Gavgani, Somayeh¹ (AUTHOR), Moradi, Hamid Reza² (AUTHOR), Azizi, Masoumeh³ (AUTHOR), Mirzabeigi, Parastoo⁴ (AUTHOR), Nazari, Farzaneh¹ (AUTHOR), Ghanei, Mostafa⁵ (AUTHOR), Mahboudi, Fereidoun⁶ (AUTHOR), Rahimi-Jamnani, Fatemeh¹ (AUTHOR) Rahimi@pasteur.ac.ir

Publikováno v: BMC Microbiology. 10/2/2024, p1-10. 10p.

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Akademický článek

Use of Patient Health Records to Quantify Drug-Related Pro-arrhythmic Risk.

Autor: Davies MR; QT-Informatics Ltd., Macclesfield, UK., Martinec M; PHC Data Science, Personalized Healthcare, Product Development, F. Hoffmann-La Roche AG, Basel, Switzerland., Walls R; PHC Data Science, Personalized Healthcare, Product Development, F. Hoffmann-La Roche AG, Basel, Switzerland., Schwarz R; Safety Analytics and Reporting, Drug Safety, Pharmaceutical Development, F. Hoffmann-La Roche AG, Basel, Switzerland., Mirams GR; Centre for Mathematical Medicine & Biology, School of Mathematical Sciences, University of Nottingham, Nottingham NG7 2RD, UK., Wang K; Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche AG, Basel, Switzerland., Steiner G; Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche AG, Basel, Switzerland., Surinach A; Genesis Research, Hoboken, NJ, USA., Flores C; Genesis Research, Hoboken, NJ, USA., Lavé T; Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche AG, Basel, Switzerland., Singer T; Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche AG, Basel, Switzerland., Polonchuk L; Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche AG, Basel, Switzerland.

Publikováno v: Cell reports. Medicine [Cell Rep Med] 2020 Aug 25; Vol. 1 (5), pp. 100076. Date of Electronic Publication: 2020 Aug 25 (Print Publication: 2020).

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Akademický článek

Model-Informed Artificial Intelligence: Reinforcement Learning for Precision Dosing.

Autor: Ribba B; F. Hoffmann La Roche Ltd., Basel, Switzerland., Dudal S; F. Hoffmann La Roche Ltd., Basel, Switzerland., Lavé T; F. Hoffmann La Roche Ltd., Basel, Switzerland., Peck RW; F. Hoffmann La Roche Ltd., Basel, Switzerland.

Publikováno v: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2020 Apr; Vol. 107 (4), pp. 853-857. Date of Electronic Publication: 2020 Feb 23.

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Akademický článek

Real-World Data and Physiologically-Based Mechanistic Models for Precision Medicine.

Autor: Wang K; Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, Basel, Switzerland., Parrott N; Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, Basel, Switzerland., Olivares-Morales A; Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, Basel, Switzerland., Dudal S; Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, Basel, Switzerland., Singer T; Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, Basel, Switzerland., Lavé T; Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, Basel, Switzerland., Ribba B; Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, Basel, Switzerland.

Publikováno v: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2020 Apr; Vol. 107 (4), pp. 694-696. Date of Electronic Publication: 2020 Feb 23.

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Akademický článek

Prediction of human pharmacokinetic parameters incorporating SMILES information.

Autor: Kwon JH; Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, Republic of Korea., Han JY; Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, Republic of Korea., Kim M; Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, Republic of Korea., Kim SK; Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, Republic of Korea., Lee DK; College of Pharmacy, Chung-Ang University, Seoul, 06974, Republic of Korea., Kim MG; Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, Republic of Korea. kimmg@ewha.ac.kr.; College of Pharmacy, Ewha Womans University, Seoul, 03760, Republic of Korea. kimmg@ewha.ac.kr.

Publikováno v: Archives of pharmacal research [Arch Pharm Res] 2024 Dec; Vol. 47 (12), pp. 914-923. Date of Electronic Publication: 2024 Nov 26.

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